Serine/threonine-protein kinase 38

Details

Name
Serine/threonine-protein kinase 38
Synonyms
  • 2.7.11.1
  • Ndr1
  • NDR1 protein kinase
  • Nuclear Dbf2-related kinase 1
Gene Name
Stk38
Organism
Mouse
Amino acid sequence
>lcl|BSEQ0052698|Serine/threonine-protein kinase 38
MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE
EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL
RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK
KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA
HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN
KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRF
CCEWEHRIGAPGVEEIKNNLFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK
PTVTTSSHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK
Number of residues
465
Molecular Weight
54173.83
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / magnesium ion binding / mitogen-activated protein kinase kinase kinase binding / protein serine kinase activity / protein serine/threonine kinase activity / protein threonine kinase activity
Processes
cellular protein modification process / intracellular signal transduction / negative regulation of MAP kinase activity / peptidyl-serine phosphorylation / protein phosphorylation
Components
cytoplasm / cytosol / nucleus
General Function
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0052699|Serine/threonine-protein kinase 38 (Stk38)
ATGGCAATGACAGGATCAACACCTTGCTCATCCATGAGTAATCATACGAAGGAGAGGGTG
ACAATGACCAAAGTGACACTGGAGAATTTTTATAGCAACCTTATCGCTCAACATGAAGAA
CGAGAAATGAGACAAAAGAAGTTAGAAAAGGTGATGGAAGAAGAAGGCCTGAAAGACGAA
GAGAAACGACTCAGAAGATCCGCGCACGCTCGGAAGGAAACAGAGTTTCTTCGATTAAAG
AGAACAAGGCTTGGACTGGAAGATTTTGAGTCTTTAAAAGTCATAGGCCGAGGAGCATTT
GGTGAGGTGCGGCTTGTTCAGAAGAAAGACACAGGGCATGTGTACGCAATGAAAATCCTG
CGCAAAGCAGACATGCTCGAGAAGGAGCAGGTTGGCCACATTCGTGCGGAGCGTGACATT
CTAGTGGAGGCAGACAGTTTGTGGGTTGTGAAAATGTTCTATAGTTTTCAGGATAAGCTA
AACCTCTACCTAATCATGGAGTTCCTGCCTGGAGGGGACATGATGACTTTATTGATGAAA
AAAGATACTCTGACAGAAGAGGAGACTCAGTTTTATATAGCAGAGACAGTATTAGCCATA
GACTCCATTCACCAGCTGGGATTCATCCACAGAGATATCAAGCCAGACAACCTTCTCTTG
GACAGCAAGGGCCATGTGAAACTTTCCGACTTTGGCCTTTGCACAGGCCTGAAAAAAGCA
CACAGGACAGAATTTTATAGGAACCTGAACCACAGCCTGCCCAGTGATTTCACTTTTCAG
AACATGAATTCCAAAAGGAAAGCAGAGACCTGGAAAAGAAACAGACGCCAGCTAGCCTTC
TCTACAGTGGGCACTCCTGACTACATTGCTCCAGAGGTGTTCATGCAGACGGGTTACAAC
AAGCTCTGCGATTGGTGGTCGCTCGGGGTAATCATGTATGAGATGCTCATCGGCTACCCA
CCATTCTGCTCCGAGACCCCACAAGAGACATACAAGAAAGTGATGAACTGGAAGGAAACT
TTGACCTTTCCTCCAGAAGTTCCTGTCTCCGAGAAAGCCAAGGGCCTGATTCTGAGGTTC
TGCTGTGAATGGGAACATAGAATCGGAGCCCCTGGAGTTGAAGAAATAAAAAATAATCTT
TTTTTTGAAGGTGTTGACTGGGAACACATCAGGGAGAGACCAGCTGCGATATCTATTGAA
ATCAAGAGCATCGATGATACCTCAAACTTCGATGAATTTCCAGAGTCTGATATTCTTAAG
CCCACAGTGACCACAAGTAGTCATCCTGAGACGGACTACAAGAACAAAGACTGGGTCTTC
ATCAATTACACATACAAGCGCTTCGAGGGCCTGACAGCCAGGGGGGCCATACCTTCGTAC
ATGAAAGCAGCAAAATAG
Chromosome Location
17
Locus
17 A3.3
External Identifiers
ResourceLink
UniProtKB IDQ91VJ4
UniProtKB Entry NameSTK38_MOUSE
General References
  1. Stegert MR, Tamaskovic R, Bichsel SJ, Hergovich A, Hemmings BA: Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. J Biol Chem. 2004 May 28;279(22):23806-12. Epub 2004 Mar 22. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]
  4. Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol. 2011 Sep;31(17):3603-15. doi: 10.1128/MCB.01389-10. Epub 2011 Jul 5. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails