Serine/threonine-protein kinase 38
Details
- Name
- Serine/threonine-protein kinase 38
- Synonyms
- 2.7.11.1
- Ndr1
- NDR1 protein kinase
- Nuclear Dbf2-related kinase 1
- Gene Name
- Stk38
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0052698|Serine/threonine-protein kinase 38 MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRF CCEWEHRIGAPGVEEIKNNLFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK PTVTTSSHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK
- Number of residues
- 465
- Molecular Weight
- 54173.83
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / magnesium ion binding / mitogen-activated protein kinase kinase kinase binding / protein serine kinase activity / protein serine/threonine kinase activity / protein threonine kinase activityProcessescellular protein modification process / intracellular signal transduction / negative regulation of MAP kinase activity / peptidyl-serine phosphorylation / protein phosphorylationComponentscytoplasm / cytosol / nucleus
- General Function
- Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0052699|Serine/threonine-protein kinase 38 (Stk38) ATGGCAATGACAGGATCAACACCTTGCTCATCCATGAGTAATCATACGAAGGAGAGGGTG ACAATGACCAAAGTGACACTGGAGAATTTTTATAGCAACCTTATCGCTCAACATGAAGAA CGAGAAATGAGACAAAAGAAGTTAGAAAAGGTGATGGAAGAAGAAGGCCTGAAAGACGAA GAGAAACGACTCAGAAGATCCGCGCACGCTCGGAAGGAAACAGAGTTTCTTCGATTAAAG AGAACAAGGCTTGGACTGGAAGATTTTGAGTCTTTAAAAGTCATAGGCCGAGGAGCATTT GGTGAGGTGCGGCTTGTTCAGAAGAAAGACACAGGGCATGTGTACGCAATGAAAATCCTG CGCAAAGCAGACATGCTCGAGAAGGAGCAGGTTGGCCACATTCGTGCGGAGCGTGACATT CTAGTGGAGGCAGACAGTTTGTGGGTTGTGAAAATGTTCTATAGTTTTCAGGATAAGCTA AACCTCTACCTAATCATGGAGTTCCTGCCTGGAGGGGACATGATGACTTTATTGATGAAA AAAGATACTCTGACAGAAGAGGAGACTCAGTTTTATATAGCAGAGACAGTATTAGCCATA GACTCCATTCACCAGCTGGGATTCATCCACAGAGATATCAAGCCAGACAACCTTCTCTTG GACAGCAAGGGCCATGTGAAACTTTCCGACTTTGGCCTTTGCACAGGCCTGAAAAAAGCA CACAGGACAGAATTTTATAGGAACCTGAACCACAGCCTGCCCAGTGATTTCACTTTTCAG AACATGAATTCCAAAAGGAAAGCAGAGACCTGGAAAAGAAACAGACGCCAGCTAGCCTTC TCTACAGTGGGCACTCCTGACTACATTGCTCCAGAGGTGTTCATGCAGACGGGTTACAAC AAGCTCTGCGATTGGTGGTCGCTCGGGGTAATCATGTATGAGATGCTCATCGGCTACCCA CCATTCTGCTCCGAGACCCCACAAGAGACATACAAGAAAGTGATGAACTGGAAGGAAACT TTGACCTTTCCTCCAGAAGTTCCTGTCTCCGAGAAAGCCAAGGGCCTGATTCTGAGGTTC TGCTGTGAATGGGAACATAGAATCGGAGCCCCTGGAGTTGAAGAAATAAAAAATAATCTT TTTTTTGAAGGTGTTGACTGGGAACACATCAGGGAGAGACCAGCTGCGATATCTATTGAA ATCAAGAGCATCGATGATACCTCAAACTTCGATGAATTTCCAGAGTCTGATATTCTTAAG CCCACAGTGACCACAAGTAGTCATCCTGAGACGGACTACAAGAACAAAGACTGGGTCTTC ATCAATTACACATACAAGCGCTTCGAGGGCCTGACAGCCAGGGGGGCCATACCTTCGTAC ATGAAAGCAGCAAAATAG
- Chromosome Location
- 17
- Locus
- 17 A3.3
- External Identifiers
Resource Link UniProtKB ID Q91VJ4 UniProtKB Entry Name STK38_MOUSE - General References
- Stegert MR, Tamaskovic R, Bichsel SJ, Hergovich A, Hemmings BA: Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. J Biol Chem. 2004 May 28;279(22):23806-12. Epub 2004 Mar 22. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]
- Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol. 2011 Sep;31(17):3603-15. doi: 10.1128/MCB.01389-10. Epub 2011 Jul 5. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details