Squalene monooxygenase
Details
- Name
- Squalene monooxygenase
- Synonyms
- 1.14.14.17
- SE
- Squalene epoxidase
- Gene Name
- ERG1
- Organism
- Yeast
- Amino acid sequence
>lcl|BSEQ0017505|Squalene monooxygenase MSSVKYDAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALREL GMIKAINNIRAVDCTGYYIKYYDETITIPYPLKKDACITNPVKPVPDAVDGVNDKLDSDS TLNVDDWDFDERVRGAAFHHGDFLMNLRQICRDEPNVTAVEATVTKILRDPSDPNTVIGV QTKQPSGTVDYHAKLTISCDGIYSKFRKELSPTNVPTIGSYFIGLYLKNAELPAKGKGHV LLGGHAPALIYSVSPTETRVLCVYVSSKPPSAANDAVYKYLRDNILPAIPKETVPAFKEA LEERKFRIMPNQYLSAMKQGSENHKGFILLGDSLNMRHPLTGGGMTVGLNDSVLLAKLLH PKFVEDFDDHQLIAKRLKTFHRKRKNLDAVINTLSISLYSLFAADKKPLRILRNGCFKYF QRGGECVNGPIGLLSGMLPFPMLLFNHFFSVAFYSVYLNFIERGLLGFPLALFEAFEVLF TAIVIFTPYLWNEIVR
- Number of residues
- 496
- Molecular Weight
- 55297.635
- Theoretical pI
- Not Available
- GO Classification
- Functionsflavin adenine dinucleotide binding / squalene monooxygenase activityProcessescell growth mode switching, budding to filamentous / cellular response to drug / cellular response to starvation / ergosterol biosynthetic process / filamentous growth / filamentous growth of a population of unicellular organisms in response to biotic stimulus / filamentous growth of a population of unicellular organisms in response to chemical stimulus / filamentous growth of a population of unicellular organisms in response to starvation / localization within membraneComponentsendoplasmic reticulum membrane / integral component of membrane / plasma membrane
- General Function
- Squalene monooxygenase activity
- Specific Function
- Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
- Pfam Domain Function
- SE (PF08491)
- Transmembrane Regions
- 4-24 431-451 466-486
- Cellular Location
- Microsome membrane
- Gene sequence
>lcl|BSEQ0017506|Squalene monooxygenase (ERG1) ATGAGTTCAGTTAAGTATGATGCTATTATTATTGGTGCAGGGGTTATTGGTCCCACCATT GCAACTGCTTTTGCCAGACAAGGGAGAAAGGTTTTGATTGTGGAAAGAGACTGGTCCAAG CCAGATAGAATTGTTGGAGAGTTGATGCAACCGGCTGGTATCAAGGCATTAAGAGAGTTG GGGATGATCAAAGCTATTAATAATATTAGGGCTGTTGATTGTACTGGGTACTATATCAAA TATTATGACGAGACCATTACTATCCCTTATCCATTGAAAAAAGATGCCTGTATCACTAAT CCAGTGAAGCCAGTTCCTGATGCCGTTGATGGTGTAAATGATAAATTGGATAGTGATTCC ACATTGAATGTTGATGACTGGGATTTTGATGAAAGAGTACGTGGGGCTGCATTTCACCAT GGGGATTTCCTTATGAATTTAAGACAAATTTGTCGTGATGAACCAAATGTTACCGCAGTT GAAGCAACAGTAACAAAGATTTTGCGTGATCCTCTGGATCCTAACACAGTTATTGGTGTG CAAACAAAACAACCCAGTGGCACTGTTGATTACCATGCAAAGTTGACAATCAGTTGTGAT GGTATTTACTCCAAATTCAGAAAGGAATTAAGTCCTACTAATGTTCCAACCATTGGCTCT TACTTTATTGGGTTGTATTTGAAGAATGCTGAATTACCAGCTAAGGGCAAAGGTCATGTG TTATTGGGAGGACATGCACCAGCATTGATATATTCAGTGTCCCCAACTGAAACACGTGTA TTGTGTGTTTATGTTTCATCAAAACCTCCTTCTGCTGCTAACGATGCAGTTTACAAGTAT TTGAGAGATAACATTTTGCCAGCAATTCCTAAAGAGACTGTTCCTGCTTTTAAGGAAGCC CTTGAAGAAAGAAAGTTTAGAATCATGCCAAACCAGTATCTTTCTGCTATGAAACAAGGT AGTGAAAACCATAAAGGGTTTATATTGTTAGGTGATTCTTTAAATATGAGACATCCATTA ACTGGGGGTGGTATGACAGTTGGTTTAAATGATAGTGTGTTATTAGCAAAATTGTTGCAT CCAAAATTTGTTGAAGATTTTGATGATCACCAATTGATTGCTAAAAGATTAAAGACATTC CACAGAAAAAGAAAGAATTTGGACGCTGTTATCAACACATTATCTATTTCATTATATTCA TTATTTGCCGCTGATAAGAAACCTTTAAGAATATTAAGAAATGGTTGTTTTAAATATTTC CAAAGAGGTGGAGAATGTGTTAACGGGCCAATTGGATTATTGAGTGGCATGTTACCATTC CCAATGTTGTTATTCAACCATTTTTTCAGTGTTGCCTTCTATTCGGTCTATTTGAATTTT ATAGAAAGAGGACTTTTGGGATTCCCATTGGCATTATTTGAGGCATTTGAAGTGTTGTTC ACTGCAATTGTAATCTTTACTCCATATTTATGGAACGAGATTGTAAGATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q92206 UniProtKB Entry Name ERG1_CANAL - General References
- Favre B, Ryder NS: Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans. Gene. 1997 Apr 11;189(1):119-26. [Article]
- Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S: The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. Epub 2004 May 3. [Article]