Estradiol 17-beta-dehydrogenase 8
Details
- Name
- Estradiol 17-beta-dehydrogenase 8
- Synonyms
- 1.1.1.62
- 17-beta-HSD 8
- 17-beta-hydroxysteroid dehydrogenase 8
- 3-oxoacyl-[acyl-carrier-protein] reductase
- FABGL
- HKE6
- Ke-6
- Protein Ke6
- Really interesting new gene 2 protein
- RING2
- SDR30C1
- Short chain dehydrogenase/reductase family 30C member 1
- Testosterone 17-beta-dehydrogenase 8
- Gene Name
- HSD17B8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010401|Estradiol 17-beta-dehydrogenase 8 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLT QTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFL ASEDSGYITGTSVEVTGGLFM
- Number of residues
- 261
- Molecular Weight
- 26973.56
- Theoretical pI
- 6.5
- GO Classification
- Functions3-hydroxyacyl-CoA dehydrogenase activity / estradiol 17-beta-dehydrogenase activity / testosterone dehydrogenase (NAD+) activityProcessesandrogen metabolic process / estrogen biosynthetic process / fatty acid biosynthetic processComponentsmitochondrial envelope / mitochondrial matrix / plasma membrane
- General Function
- Testosterone dehydrogenase (nad+) activity
- Specific Function
- NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion matrix
- Gene sequence
>lcl|BSEQ0010402|Estradiol 17-beta-dehydrogenase 8 (HSD17B8) ATGGCGTCTCAGCTCCAGAACCGACTCCGCTCCGCACTGGCCTTGGTCACAGGTGCGGGG AGCGGCATCGGCCGAGCGGTCAGTGTACGCCTGGCCGGAGAGGGGGCCACCGTAGCTGCC TGCGACCTGGACCGGGCAGCGGCACAGGAGACGGTGCGGCTGCTGGGCGGGCCAGGGAGC AAGGAGGGGCCGCCCCGAGGGAACCATGCTGCCTTCCAGGCTGACGTGTCTGAGGCCAGG GCCGCCAGGTGCCTGCTGGAACAAGTGCAGGCCTGCTTTTCTCGCCCACCATCTGTCGTT GTGTCCTGTGCGGGCATCACCCAGGATGAGTTTCTGCTGCACATGTCTGAGGATGACTGG GACAAAGTCATAGCTGTCAACCTCAAGGGCACCTTCCTAGTCACTCAGGCTGCAGCACAA GCCCTGGTGTCCAATGGTTGTCGTGGTTCCATCATCAACATCAGTAGCATCGTAGGAAAG GTGGGGAACGTGGGGCAGACAAACTATGCAGCATCCAAGGCTGGAGTGATTGGGCTGACC CAGACCGCAGCCCGGGAGCTTGGACGACATGGGATCCGCTGTAACTCTGTCCTCCCAGGG TTCATTGCAACACCCATGACACAGAAAGTGCCACAGAAAGTGGTGGACAAGATTACTGAA ATGATCCCGATGGGACACTTGGGGGACCCTGAGGATGTGGCAGATGTGGTCGCATTCTTG GCATCTGAAGATAGTGGATACATCACAGGGACCTCAGTGGAAGTCACTGGAGGTCTTTTC ATGTAA
- Chromosome Location
- 6
- Locus
- 6p21.3
- External Identifiers
Resource Link UniProtKB ID Q92506 UniProtKB Entry Name DHB8_HUMAN GenBank Protein ID 30583317 GenBank Gene ID BT007239 GenAtlas ID HSD17B8 HGNC ID HGNC:3554 - General References
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