Heat shock protein 105 kDa

Details

Name

Heat shock protein 105 kDa

Synonyms

• Antigen NY-CO-25
• Heat shock 110 kDa protein
• HSP105
• HSP110
• KIAA0201

Gene Name

HSPH1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0049771|Heat shock protein 105 kDa
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHA
NNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAM
LLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALN
YGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKL
VEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGK
MNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGK
DISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVF
SRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKV
KVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGT
QPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEA
NLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQ
DHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELG
QRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVV
RAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPH
QNGECYPNEKNSVNMDLD

Number of residues

858

Molecular Weight

96864.305

Theoretical pI

Not Available

GO Classification

Functions

adenyl-nucleotide exchange factor activity / alpha-tubulin binding / ATP binding

Processes

chaperone mediated protein folding requiring cofactor / negative regulation of establishment of protein localization to mitochondrion / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / negative regulation of p38MAPK cascade / positive regulation of MHC class I biosynthetic process / positive regulation of NK T cell activation / positive regulation of protein tyrosine kinase activity / positive regulation of transcription from RNA polymerase II promoter / receptor-mediated endocytosis / regulation of cellular response to heat / response to unfolded protein

Components

cytoplasm / cytosol / endocytic vesicle lumen / extracellular exosome / extracellular region / microtubule / nucleoplasm

General Function

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Specific Function

Adenyl-nucleotide exchange factor activity

Pfam Domain Function

• HSP70 (PF00012)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0049772|Heat shock protein 105 kDa (HSPH1)
ATGTCGGTGGTGGGGTTGGACGTGGGCTCGCAGAGCTGCTACATCGCGGTAGCCCGGGCC
GGGGGCATCGAGACCATCGCCAATGAGTTCAGCGACCGGTGCACCCCGTCAGTCATATCA
TTTGGATCAAAAAATAGAACAATCGGAGTTGCAGCCAAAAATCAGCAAATCACTCATGCA
AACAATACGGTGTCTAACTTCAAAAGATTTCATGGCCGAGCATTCAATGACCCCTTCATT
CAAAAGGAGAAGGAAAACTTGAGTTACGATTTGGTTCCATTGAAAAATGGTGGAGTTGGA
ATAAAGGTAATGTACATGGGTGAAGAACATCTATTTAGTGTGGAGCAGATAACAGCCATG
TTGTTGACTAAGCTGAAGGAAACTGCTGAAAACAGCCTCAAGAAACCAGTAACAGATTGT
GTTATTTCAGTCCCCTCCTTCTTTACAGATGCTGAGAGGCGATCTGTGTTAGATGCTGCA
CAGATTGTTGGCCTAAACTGTTTAAGACTTATGAATGACATGACAGCTGTTGCTTTGAAT
TACGGAATTTATAAGCAGGATCTCCCAAGCCTGGATGAGAAACCTCGGATAGTGGTTTTT
GTTGATATGGGACATTCAGCTTTTCAAGTGTCTGCTTGTGCTTTTAACAAGGGAAAATTG
AAGGTACTGGGAACAGCTTTTGATCCTTTCTTAGGAGGAAAAAACTTCGATGAAAAGTTA
GTGGAACATTTTTGTGCAGAATTTAAAACTAAGTACAAGTTGGATGCAAAATCCAAAATA
CGAGCACTCCTACGTCTGTATCAGGAATGTGAAAAACTGAAAAAGCTAATGAGCTCTAAC
AGCACAGACCTTCCACTGAATATCGAATGCTTTATGAATGATAAAGATGTTTCCGGAAAG
ATGAACAGGTCACAATTTGAAGAACTCTGTGCTGAACTTCTGCAAAAGATAGAAGTACCC
CTTTATTCACTGTTGGAACAAACTCATCTCAAAGTAGAAGATGTGAGTGCAGTTGAGATT
GTTGGAGGCGCTACACGAATTCCAGCTGTGAAGGAAAGAATTGCCAAATTCTTTGGAAAA
GATATTAGCACAACACTCAATGCAGATGAAGCAGTAGCCAGAGGATGTGCATTACAGTGT
GCAATACTTTCCCCGGCATTTAAAGTTAGAGAATTTTCCGTCACAGATGCAGTTCCTTTT
CCAATATCTCTGATCTGGAACCATGATTCAGAAGATACTGAAGGTGTTCATGAAGTCTTT
AGTCGAAACCATGCTGCTCCTTTCTCCAAAGTTCTCACCTTTCTGAGAAGGGGGCCTTTT
GAGCTAGAAGCTTTCTATTCTGATCCCCAAGGAGTTCCATATCCAGAAGCAAAAATAGGC
CGCTTTGTAGTTCAGAATGTTTCTGCACAGAAAGATGGAGAAAAATCTAGAGTAAAAGTC
AAAGTGCGAGTCAACACCCATGGCATTTTCACCATCTCTACGGCATCTATGGTGGAGAAA
GTCCCAACTGAGGAGAATGAAATGTCTTCTGAAGCTGACATGGAGTGTCTGAATCAGAGA
CCACCAGAAAACCCAGACACTGATAAAAATGTCCAGCAAGACAACAGTGAAGCTGGAACA
CAGCCCCAGGTACAAACTGATGCTCAACAAACCTCACAGTCTCCCCCTTCACCTGAACTT
ACCTCAGAAGAAAACAAAATCCCAGATGCTGACAAAGCAAATGAAAAAAAAGTTGACCAG
CCTCCAGAAGCTAAAAAGCCCAAAATAAAGGTGGTGAATGTTGAGCTGCCTATTGAAGCC
AACTTGGTCTGGCAGTTAGGGAAAGACCTTCTTAACATGTATATTGAGACAGAGGGTAAG
ATGATAATGCAAGATAAATTGGAAAAAGAAAGGAATGATGCTAAAAATGCAGTTGAGGAA
TATGTGTATGAGTTCAGAGACAAGCTGTGTGGACCATATGAAAAATTTATATGTGAGCAG
GATCATCAAAATTTTTTGAGACTCCTCACAGAAACTGAAGACTGGCTGTATGAAGAAGGA
GAGGACCAAGCTAAACAAGCATATGTTGACAAGTTGGAAGAATTAATGAAAATTGGCACT
CCAGTTAAAGTTCGGTTTCAGGAAGCTGAAGAACGGCCAAAAATGTTTGAAGAACTAGGA
CAGAGGCTGCAGCATTATGCCAAGATAGCAGCTGACTTCAGAAATAAGGATGAGAAATAC
AACCATATTGATGAGTCTGAAATGAAAAAAGTGGAGAAGTCTGTTAATGAAGTGATGGAA
TGGATGAATAATGTCATGAATGCTCAGGCTAAAAAGAGTCTTGATCAGGATCCAGTTGTA
CGTGCTCAGGAAATTAAAACAAAAATCAAGGAATTGAACAACACATGTGAACCCGTTGTA
ACACAACCGAAACCAAAAATTGAATCACCCAAACTGGAAAGAACTCCAAATGGCCCAAAT
ATTGATAAAAAGGAAGAAGATTTAGAAGACAAAAACAATTTTGGTGCTGAACCTCCACAT
CAGAATGGTGAATGTTACCCTAATGAGAAAAATTCTGTTAATATGGACTTGGACTAG

Chromosome Location

13

Locus

13q12.3

External Identifiers

Resource	Link
UniProtKB ID	Q92598
UniProtKB Entry Name	HS105_HUMAN
HGNC ID	HGNC:16969

General References

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6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
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18. Rauch JN, Gestwicki JE: Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 Dec 5. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12695	Phenethyl Isothiocyanate	investigational	unknown		Details