High affinity immunoglobulin gamma Fc receptor IB
Details
- Name
- High affinity immunoglobulin gamma Fc receptor IB
- Synonyms
- Fc-gamma RIB
- FcRIB
- hFcgammaRIB
- IGFRB
- IgG Fc receptor IB
- Gene Name
- FCGR1B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009601|High affinity immunoglobulin gamma Fc receptor IB MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFMEGEPL ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG ISQYTVKGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWNLEISLDSGHE KKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
- Number of residues
- 280
- Molecular Weight
- 32231.795
- Theoretical pI
- Not Available
- GO Classification
- Functionsimmunoglobulin receptor activityProcessesadaptive immune response / antigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of peptide antigen via MHC class I / cytokine-mediated signaling pathway / Fc receptor signaling pathway / immune response / interferon-gamma-mediated signaling pathwayComponentsclathrin-coated endocytic vesicle membrane / early endosome membrane / integral component of membrane / plasma membrane
- General Function
- Immunoglobulin receptor activity
- Specific Function
- May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
- Pfam Domain Function
- Ig_2 (PF13895)
- Transmembrane Regions
- 199-219
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020794|High affinity immunoglobulin gamma Fc receptor IB (FCGR1B) ATGTGGTTCTTGACAACTCTGCTCCTTTGGGGCTGGCTACTACTGCAGGTCTCCAGCAGA GTCTTCATGGAAGGAGAACCTCTGGCCTTGAGGTGTCATGCGTGGAAGGATAAGCTGGTG TACAATGTGCTTTACTATCGAAATGGCAAAGCCTTTAAGTTTTTCCACTGGAATTCTAAC CTCACCATTCTGAAAACCAACATAAGTCACAATGGCACCTACCATTGCTCAGGCATGGGA AAGCATCGCTACACATCAGCAGGAATATCACAATACACTGTGAAAGGCCTCCAGTTACCA ACTCCTGTCTGGTTTCATGTCCTTTTCTATCTGGCAGTGGGAATAATGTTTTTAGTGAAC ACTGTTCTCTGGGTGACAATACGTAAAGAACTGAAAAGAAAGAAAAAGTGGAATTTAGAA ATCTCTTTGGATTCTGGTCATGAGAAGAAGGTAATTTCCAGCCTTCAAGAAGACAGACAT TTAGAAGAAGAGCTGAAATGTCAGGAACAAAAAGAAGAACAGCTGCAGGAAGGGGTGCAC CGGAAGGAGCCCCAGGGGGCCACGTAG
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q92637 UniProtKB Entry Name FCGRB_HUMAN HGNC ID HGNC:3614 - General References
- Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP: Novel Fc gamma receptor I family gene products in human mononuclear cells. J Clin Invest. 1992 Nov;90(5):2102-9. [Article]
- Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA: Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure. J Exp Med. 1992 Oct 1;176(4):1115-23. [Article]
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- Maresco DL, Chang E, Theil KS, Francke U, Anderson CL: The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21. Cytogenet Cell Genet. 1996;73(3):157-63. [Article]
- Ernst LK, Duchemin AM, Miller KL, Anderson CL: Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts. Mol Immunol. 1998 Oct;35(14-15):943-54. [Article]