TetX family tetracycline inactivation enzyme
Details
- Name
- TetX family tetracycline inactivation enzyme
- Synonyms
- TetX2 protein
- Gene Name
- tetX2
- Organism
- Bacteroides thetaiotaomicron
- Amino acid sequence
>lcl|BSEQ0049435|TetX family tetracycline inactivation enzyme MTMRIDTDKQMNLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTL DLHKGSGQEAMKKAGLLQTYYDLALPMGVNIADEKGNILSTKNVKPENRFDNPEINRNDL RAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETADLVILANGGMSKVRKFVTD TEVEETGTFNIQADIHQPEINCPGFFQLCNGNRLMASHQGNLLFANPNNNGALHFGISFK TPDEWKNQTQVDFQNRNSVVDFLLKEFSDWDERYKELIHTTLSFVGLATRIFPLEKPWKS KRPLPITMIGDAAHLMPPFAGQGVNSGLVDALILSDNLADGKFNSIEEAVKNYEQQMFIY GKEAQEESTQNEIEMFKPDFTFQQLLNV
- Number of residues
- 388
- Molecular Weight
- 43707.345
- Theoretical pI
- Not Available
- GO Classification
- FunctionsFAD binding / oxidoreductase activity
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Pfam Domain Function
- FAD_binding_3 (PF01494)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q93L51 UniProtKB Entry Name Q93L51_BACT4 - General References
- Whittle G, Hund BD, Shoemaker NB, Salyers AA: Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT. Appl Environ Microbiol. 2001 Aug;67(8):3488-95. [Article]
- Volkers G, Palm GJ, Weiss MS, Wright GD, Hinrichs W: Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase. FEBS Lett. 2011 Apr 6;585(7):1061-6. doi: 10.1016/j.febslet.2011.03.012. Epub 2011 Mar 12. [Article]
- Walkiewicz K, Davlieva M, Wu G, Shamoo Y: Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution. Proteins. 2011 Jul;79(7):2335-40. doi: 10.1002/prot.23052. Epub 2011 May 16. [Article]
- Volkers G, Damas JM, Palm GJ, Panjikar S, Soares CM, Hinrichs W: Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX. Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1758-67. doi: 10.1107/S0907444913013802. Epub 2013 Aug 15. [Article]