Serine dehydratase-like
Details
- Name
- Serine dehydratase-like
- Synonyms
- L-serine deaminase
- L-serine dehydratase/L-threonine deaminase
- L-threonine dehydratase
- SDH 2
- Serine dehydratase 2
- TDH
- Gene Name
- SDSL
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011568|Serine dehydratase-like MDGPVAEHAKQEPFHVVTPLLESWALSQVAGMPVFLKCENVQPSGSFKIRGIGHFCQEMA KKGCRHLVCSSGGNAGIAAAYAARKLGIPATIVLPESTSLQVVQRLQGEGAEVQLTGKVW DEANLRAQELAKRDGWENVPPFDHPLIWKGHASLVQELKAVLRTPPGALVLAVGGGGLLA GVVAGLLEVGWQHVPIIAMETHGAHCFNAAITAGKLVTLPDITSVAKSLGAKTVAARALE CMQVCKIHSEVVEDTEAVSAVQQLLDDERMLVEPACGAALAAIYSGLLRRLQAEGCLPPS LTSVVVIVCGGNNINSRELQALKTHLGQV
- Number of residues
- 329
- Molecular Weight
- 34674.01
- Theoretical pI
- 6.88
- GO Classification
- FunctionsL-serine ammonia-lyase activity / L-threonine ammonia-lyase activity / pyridoxal phosphate bindingProcessesL-serine catabolic process / threonine catabolic processComponentscytoplasm / extracellular exosome / mitochondrion
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Has low serine dehydratase and threonine dehydratase activity.
- Pfam Domain Function
- PALP (PF00291)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011569|Serine dehydratase-like (SDSL) ATGGACGGCCCTGTGGCAGAGCATGCCAAGCAGGAGCCCTTTCACGTGGTCACACCTCTG TTGGAGAGCTGGGCGCTGTCCCAGGTGGCGGGCATGCCTGTCTTCCTCAAGTGTGAGAAT GTGCAGCCCAGCGGCTCCTTCAAGATTCGGGGCATTGGGCATTTCTGCCAGGAGATGGCC AAGAAGGGATGCAGACACCTGGTGTGCTCCTCAGGGGGTAATGCGGGCATCGCTGCTGCC TATGCTGCTAGGAAGCTGGGCATTCCTGCCACCATCGTGCTCCCCGAGAGCACCTCCCTG CAGGTGGTGCAGAGGCTGCAGGGGGAGGGGGCCGAGGTTCAGCTGACTGGAAAGGTCTGG GACGAGGCCAATCTGAGGGCGCAAGAGTTGGCCAAGAGGGACGGCTGGGAGAATGTCCCC CCGTTTGACCACCCCCTAATATGGAAAGGCCACGCCAGCCTGGTGCAGGAGCTGAAAGCA GTGCTGAGGACCCCACCAGGTGCCCTGGTGCTGGCAGTTGGGGGTGGGGGTCTCCTGGCC GGGGTGGTGGCTGGCCTGCTGGAGGTGGGCTGGCAGCATGTACCCATCATTGCCATGGAG ACCCATGGGGCACACTGCTTCAATGCGGCCATCACAGCCGGCAAGCTGGTCACACTTCCA GACATCACCAGTGTGGCCAAGAGCCTGGGTGCCAAGACGGTGGCCGCTCGGGCCCTGGAG TGCATGCAGGTGTGCAAGATTCACTCTGAAGTGGTGGAGGACACCGAGGCTGTGAGCGCT GTGCAGCAGCTCCTGGATGATGAGCGTATGCTGGTGGAGCCTGCCTGTGGGGCAGCCTTA GCAGCCATCTACTCAGGCCTCCTGCGGAGGCTCCAGGCCGAGGGCTGCCTGCCCCCTTCC CTGACTTCAGTTGTGGTAATCGTGTGTGGAGGCAACAACATCAACAGCCGAGAGCTGCAG GCTTTGAAAACCCACCTGGGCCAGGTCTGA
- Chromosome Location
- 12
- Locus
- 12q24.13
- External Identifiers
Resource Link UniProtKB ID Q96GA7 UniProtKB Entry Name SDSL_HUMAN GenBank Protein ID 33150744 GenBank Gene ID AF134473 GenAtlas ID SDSL HGNC ID HGNC:30404 - General References
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C: Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features. Mol Cell Proteomics. 2012 Jun;11(6):M111.015131. doi: 10.1074/mcp.M111.015131. Epub 2012 Jan 5. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Yamada T, Komoto J, Kasuya T, Takata Y, Ogawa H, Mori H, Takusagawa F: A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies. Biochim Biophys Acta. 2008 May;1780(5):809-18. doi: 10.1016/j.bbagen.2008.01.020. Epub 2008 Feb 19. [Article]