Long-chain-fatty-acid--CoA ligase ACSBG1

Details

Name
Long-chain-fatty-acid--CoA ligase ACSBG1
Synonyms
  • 6.2.1.3
  • Acyl-CoA synthetase bubblegum family member 1
  • BGM
  • hBG1
  • hsBG
  • hsBGM
  • KIAA0631
  • Lipidosin
  • LPD
Gene Name
ACSBG1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037276|Long-chain-fatty-acid--CoA ligase ACSBG1
MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHA
LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLI
ALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFA
GGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPP
NKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNIT
WTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSL
VNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDL
KPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETS
GPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAI
DEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLI
GDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQA
IEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQ
EQKM
Number of residues
724
Molecular Weight
81289.605
Theoretical pI
5.86
GO Classification
Functions
ATP binding / long-chain fatty acid-CoA ligase activity / very long-chain fatty acid-CoA ligase activity
Processes
cellular lipid metabolic process / long-chain fatty acid metabolic process / long-chain fatty-acyl-CoA biosynthetic process / myelination / response to glucocorticoid / small molecule metabolic process / triglyceride biosynthetic process / very long-chain fatty acid metabolic process
Components
cytoplasm / cytoplasmic membrane-bounded vesicle / cytosol / endoplasmic reticulum
General Function
Very long-chain fatty acid-coa ligase activity
Specific Function
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012978|Long-chain-fatty-acid--CoA ligase ACSBG1 (ACSBG1)
ATGCCACGCAATTCTGGAGCTGGATACGGCTGCCCACACGGGGACCCCAGCATGCTGGAC
AGCAGAGAGACCCCACAGGAGAGCCGGCAGGACATGATTGTGAGGACCACCCAAGAAAAA
TTGAAAACCAGCTCACTGACTGACAGGCAGCCACTCTCCAAAGAGTCCCTGAACCATGCT
CTCGAGCTCTCAGTGCCAGAGAAGGTGAATAATGCCCAGTGGGATGCTCCAGAGGAGGCG
CTGTGGACGACTCGGGCCGATGGGCGGGTGCGCCTGCGCATAGACCCCAGCTGCCCACAG
CTTCCCTACACTGTGCATCGGATGTTCTACGAGGCCCTGGATAAGTATGGGGACCTCATC
GCTTTGGGCTTCAAGCGCCAGGACAAGTGGGAACACATCTCCTACTCCCAATACTACCTG
CTCGCCCGCAGAGCCGCCAAGGGCTTCCTGAAGCAGGCCCACAGTGTGGCCATCCTCGGC
TTCAACTCCCCGGAGTGGTTCTTCTCGGCAGTGGGCACAGTATTTGCAGGTGGCATCGTC
ACTGGCATCTACACCACCAGCTCCCCAGAGGCCTGCCAGTACATCGCTTATGACTGCTGC
GCCAATGTCATCATGGTCGACACGCAGAAGCAGCTGGAAAAGATCCTGAAGATCTGGAAA
CAGTTGCCACATCTAAAGGCAGTCGTGATATATAAAGAACCTCCTCCAAACAAGATGGCC
AATGTGTACACGATGGAGGAATTCATGGAGCTGGGGAATGAAGTGCCTGAGGAAGCCCTG
GACGCCATCATTGACACCCAGCAGCCCAACCAGTGCTGTGTGCTAGTCTACACTTCCGGC
ACCACTGGGAACCCCAAGGGCGTGATGCTGAGTCAAGACAATATCACGTGGACGGCACGG
TACGGCAGCCAGGCCGGTGACATCCGGCCGGCAGAAGTCCAGCAGGAGGTGGTAGTCAGC
TACCTGCCCCTCAGCCATATTGCCGCCCAGATCTACGACCTGTGGACAGGCATCCAGTGG
GGGGCCCAGGTTTGCTTTGCCGAACCCGACGCCCTGAAGGGGAGCCTGGTGAACACGCTG
CGGGAGGTGGAGCCCACATCACACATGGGGGTGCCCCGGGTATGGGAGAAGATCATGGAG
CGCATCCAGGAGGTGGCGGCTCAGTCTGGCTTCATCCGGCGAAAGATGCTGCTGTGGGCC
ATGTCGGTGACCTTGGAGCAGAACCTCACCTGCCCCGGCAGCGACCTGAAGCCCTTCACA
ACCAGACTGGCAGATTACCTGGTGCTAGCCAAGGTTCGCCAGGCACTGGGATTTGCCAAG
TGTCAAAAGAACTTCTATGGAGCGGCCCCCATGATGGCAGAGACACAGCACTTCTTCCTG
GGTCTCAACATCCGCTTGTATGCGGGCTACGGCCTCAGTGAGACCTCAGGCCCCCACTTC
ATGTCCAGTCCCTACAACTACCGGCTGTACAGCTCAGGCAAGTTGGTGCCCGGCTGTCGG
GTGAAGCTGGTGAACCAGGACGCAGAGGGCATTGGCGAGATCTGCCTGTGGGGCCGCACC
ATATTCATGGGCTACCTGAACATGGAGGACAAGACTTGTGAGGCCATCGACGAGGAAGGC
TGGCTGCACACGGGTGATGCTGGCCGCCTGGACGCCGATGGCTTCCTCTACATCACTGGG
CGCCTCAAAGAATTAATCATCACAGCTGGTGGGGAGAATGTGCCCCCTGTGCCCATCGAG
GAGGCCGTGAAGATGGAGCTGCCCATCATCAGCAACGCCATGCTCATTGGGGACCAGAGG
AAGTTCCTGTCCATGCTGCTCACCTTGAAGTGCACTCTGGACCCAGACACCTCTGACCAG
ACTGATAATCTGACTGAACAAGCTATGGAGTTCTGCCAGAGGGTGGGCAGCAGAGCCACC
ACAGTGTCCGAGATCATAGAGAAGAAGGATGAGGCCGTGTACCAGGCCATCGAAGAGGGG
ATCCGGAGGGTCAACATGAACGCGGCGGCCCGGCCCTACCACATCCAGAAGTGGGCCATT
CTCGAGAGAGACTTCTCCATTTCGGGTGGAGAGTTGGGTCCCACGATGAAACTGAAACGG
CTCACAGTTTTGGAGAAGTACAAAGGTATCATTGACTCCTTTTACCAAGAGCAAAAAATG
TAA
Chromosome Location
15
Locus
15q23-q24
External Identifiers
ResourceLink
UniProtKB IDQ96GR2
UniProtKB Entry NameACBG1_HUMAN
GenBank Protein ID9957538
GenBank Gene IDAF179481
HGNC IDHGNC:29567
General References
  1. Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA: Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids. J Biol Chem. 2000 Nov 10;275(45):35162-9. [Article]
  2. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Jun 30;5(3):169-76. [Article]
  3. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  5. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Pei Z, Oey NA, Zuidervaart MM, Jia Z, Li Y, Steinberg SJ, Smith KD, Watkins PA: The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation.. J Biol Chem. 2003 Nov 21;278(47):47070-8. Epub 2003 Sep 15. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB083262-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONEexperimentalunknownDetails