Zinc transporter ZIP13

Details

Name
Zinc transporter ZIP13
Synonyms
  • LIV-1 subfamily of ZIP zinc transporter 9
  • LZT-Hs9
  • Solute carrier family 39 member 13
  • ZIP-13
  • ZIP13
  • Zrt- and Irt-like protein 13
Gene Name
SLC39A13
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052363|Zinc transporter ZIP13
MPGCPCPGCGMAGPRLLFLTALALELLERAGGSQPALRSRGTATACRLDNKESESWGALL
SGERLDTWICSLLGSLMVGLSGVFPLLVIPLEMGTMLRSEAGAWRLKQLLSFALGGLLGN
VFLHLLPEAWAYTCSASPGGEGQSLQQQQQLGLWVIAGILTFLALEKMFLDSKEEGTSQA
PNKDPTAAAAALNGGHCLAQPAAEPGLGAVVRSIKVSGYLNLLANTIDNFTHGLAVAASF
LVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAAKLQLSTALGGLLGAGFAICT
QSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALVNVLPDLLEEEDPWRSLQQLLLLCAGI
VVMVLFSLFVD
Number of residues
371
Molecular Weight
39010.1
Theoretical pI
Not Available
GO Classification
Functions
protein homodimerization activity / zinc ion transmembrane transporter activity
Processes
cellular zinc ion homeostasis / connective tissue development / response to zinc ion / zinc ion transmembrane transport
Components
cell / endoplasmic reticulum / Golgi apparatus / integral component of Golgi membrane / integral component of membrane / perinuclear region of cytoplasm
General Function
Acts as a zinc-influx transporter.
Specific Function
Protein homodimerization activity
Pfam Domain Function
Transmembrane Regions
8-28 69-89 109-129 150-170 236-256 279-299 317-337 350-370
Cellular Location
Golgi apparatus membrane
Gene sequence
>lcl|BSEQ0052364|Zinc transporter ZIP13 (SLC39A13)
ATGCCTGGATGTCCCTGCCCTGGCTGTGGCATGGCGGGCCCAAGGCTCCTCTTCCTCACT
GCCCTTGCCCTGGAGCTCTTGGAAAGGGCTGGGGGTTCCCAGCCGGCCCTCCGGAGCCGG
GGGACTGCGACGGCCTGTCGCCTGGACAACAAGGAAAGCGAGTCCTGGGGGGCTCTGCTG
AGCGGAGAGCGGCTGGACACCTGGATCTGCTCCCTCCTGGGTTCCCTCATGGTGGGGCTC
AGTGGGGTCTTCCCGTTGCTTGTCATTCCCCTAGAGATGGGGACCATGCTGCGCTCAGAA
GCTGGGGCCTGGCGCCTGAAGCAGCTGCTCAGCTTCGCCCTGGGGGGACTCTTGGGCAAT
GTGTTTCTGCATCTGCTGCCCGAAGCCTGGGCCTACACGTGCAGCGCCAGCCCTGGTGGT
GAGGGGCAGAGCCTGCAGCAGCAGCAACAGCTGGGGCTGTGGGTCATTGCTGGCATCCTG
ACCTTCCTGGCGTTGGAGAAGATGTTCCTGGACAGCAAGGAGGAGGGGACCAGCCAGGCC
CCCAACAAAGACCCCACTGCTGCTGCCGCCGCGCTCAATGGAGGCCACTGTCTGGCCCAG
CCGGCTGCAGAGCCCGGCCTCGGTGCCGTGGTCCGGAGCATCAAAGTCAGCGGCTACCTC
AACCTGCTGGCCAACACCATCGATAACTTCACCCACGGGCTGGCTGTGGCTGCCAGCTTC
CTTGTGAGCAAGAAGATCGGGCTCCTGACAACCATGGCCATCCTCCTGCATGAGATCCCC
CATGAGGTGGGCGACTTTGCCATCCTGCTCCGGGCCGGCTTTGACCGATGGAGCGCAGCC
AAGCTGCAACTCTCAACAGCGCTGGGGGGCCTACTGGGCGCTGGCTTCGCCATCTGTACC
CAGTCCCCCAAGGGAGTAGTTGGGTGTTCTCCCGCTGCAGAGGAGACGGCAGCCTGGGTC
CTGCCCTTCACCTCTGGCGGCTTTCTCTACATCGCCTTGGTGAACGTGCTCCCTGACCTC
TTGGAAGAAGAGGACCCGTGGCGCTCCCTGCAGCAGCTGCTTCTGCTCTGTGCGGGCATC
GTGGTAATGGTGCTGTTCTCGCTCTTCGTGGATTAA
Chromosome Location
11
Locus
11p11.2
External Identifiers
ResourceLink
UniProtKB IDQ96H72
UniProtKB Entry NameS39AD_HUMAN
HGNC IDHGNC:20859
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  2. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  5. Bin BH, Fukada T, Hosaka T, Yamasaki S, Ohashi W, Hojyo S, Miyai T, Nishida K, Yokoyama S, Hirano T: Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome. J Biol Chem. 2011 Nov 18;286(46):40255-65. doi: 10.1074/jbc.M111.256784. Epub 2011 Sep 14. [Article]
  6. Giunta C, Elcioglu NH, Albrecht B, Eich G, Chambaz C, Janecke AR, Yeowell H, Weis M, Eyre DR, Kraenzlin M, Steinmann B: Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome--an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13. Am J Hum Genet. 2008 Jun;82(6):1290-305. doi: 10.1016/j.ajhg.2008.05.001. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB14533Zinc chlorideapproved, investigationalunknownsubstrateDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknownsubstrateDetails