Proteinase-activated receptor 4

Details

Name
Proteinase-activated receptor 4
Synonyms
  • Coagulation factor II receptor-like 3
  • PAR-4
  • PAR4
  • Thrombin receptor-like 3
Gene Name
F2RL3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049687|Proteinase-activated receptor 4
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
Number of residues
385
Molecular Weight
41132.43
Theoretical pI
Not Available
GO Classification
Functions
G-protein coupled receptor activity / thrombin-activated receptor activity
Processes
blood coagulation / phospholipase C-activating G-protein coupled receptor signaling pathway / platelet activation / platelet dense granule organization / positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway / positive regulation of release of sequestered calcium ion into cytosol / positive regulation of Rho protein signal transduction / response to wounding / signal transduction
Components
extracellular region / integral component of plasma membrane / plasma membrane
General Function
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Specific Function
G-protein coupled receptor activity
Pfam Domain Function
Transmembrane Regions
83-103 109-129 152-172 193-213 248-268 284-304 320-343
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0049688|Proteinase-activated receptor 4 (F2RL3)
ATGTGGGGGCGACTGCTCCTGTGGCCCCTGGTGCTGGGGTTCAGCCTGTCTGGCGGCACC
CAGACCCCCAGCGTCTACGACGAGAGCGGGAGCACCGGAGGTGGTGATGACAGCACGCCC
TCAATCCTGCCTGCCCCCCGCGGCTACCCAGGCCAAGTCTGTGCCAATGACAGTGACACC
CTGGAGCTCCCGGACAGCTCACGGGCACTGCTTCTGGGCTGGGTGCCCACCAGGCTGGTG
CCCGCCCTCTATGGGCTGGTCCTGGTGGTGGGGCTGCCGGCCAATGGGCTGGCGCTGTGG
GTGCTGGCCACGCAGGCACCTCGGCTGCCCTCCACCATGCTGCTGATGAACCTCGCGGCT
GCTGACCTCCTGCTGGCCCTGGCGCTGCCCCCGCGGATCGCCTACCACCTGCGTGGCCAG
CGCTGGCCCTTCGGGGAGGCCGCCTGCCGCCTGGCCACGGCCGCACTCTATGGTCACATG
TATGGCTCAGTGCTGCTGCTGGCCGCCGTCAGCCTGGATCGCTACCTGGCCCTGGTGCAC
CCGCTGCGGGCCCGCGCCCTGCGTGGCCGGCGCCTGGCCCTTGGACTCTGCATGGCTGCT
TGGCTCATGGCGGCCGCCCTGGCACTGCCCCTGACACTGCAGCGGCAGACCTTCCGGCTG
GCGCGCTCCGATCGCGTGCTCTGCCATGACGCGCTGCCCCTGGACGCACAGGCCTCCCAC
TGGCAACCGGCCTTCACCTGCCTGGCGCTGTTGGGCTGTTTCCTGCCCCTGCTGGCCATG
CTGCTGTGCTACGGGGCCACCCTGCACACGCTGGCGGCCAGCGGCCGGCGCTACGGCCAC
GCGCTGAGGCTGACCGCAGTGGTGCTGGCCTCCGCCGTGGCCTTCTTCGTGCCCAGCAAC
CTGCTGCTGCTGCTGCATTACTCGGACCCGAGCCCCAGCGCCTGGGGCAACCTCTATGGT
GCCTACGTGCCCAGCCTGGCGCTGAGCACCCTCAACAGCTGCGTGGATCCCTTCATCTAC
TACTACGTGTCGGCCGAGTTCAGGGACAAGGTGCGGGCAGGGCTCTTCCAACGGTCGCCG
GGGGACACCGTGGCCTCCAAGGCCTCTGCGGAAGGGGGCAGCCGGGGCATGGGCACCCAC
TCCTCTTTGCTCCAGTGA
Chromosome Location
19
Locus
19p13.11
External Identifiers
ResourceLink
UniProtKB IDQ96RI0
UniProtKB Entry NamePAR4_HUMAN
HGNC IDHGNC:3540
General References
  1. Kahn ML, Hammes SR, Botka C, Coughlin SR: Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. J Biol Chem. 1998 Sep 4;273(36):23290-6. [Article]
  2. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR: A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13;394(6694):690-4. [Article]
  3. Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW, Foster DC: Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6642-6. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR: Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11300Thrombinapproved, investigationalunknownDetails