Protein deglycase DJ-1

Details

Name
Protein deglycase DJ-1
Synonyms
  • 3.1.2.-
  • DJ-1
  • Oncogene DJ1
  • Parkinson disease protein 7
Gene Name
PARK7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010694|Protein deglycase DJ-1
MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLED
AKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFG
SKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQ
VKAPLVLKD
Number of residues
189
Molecular Weight
19890.88
Theoretical pI
6.78
GO Classification
Functions
androgen receptor binding / copper ion binding / cupric ion binding / cuprous ion binding / cytokine binding / enzyme binding / glyoxalase (glycolic acid-forming) activity / glyoxalase III activity / identical protein binding / kinase binding / L-dopa decarboxylase activator activity / mercury ion binding / mRNA binding / oxidoreductase activity, acting on peroxide as acceptor / peptidase activity / peroxiredoxin activity / protein homodimerization activity / receptor binding / repressing transcription factor binding / scaffold protein binding / small protein activating enzyme binding / superoxide dismutase copper chaperone activity / transcription coactivator activity / transcription factor binding / tyrosine 3-monooxygenase activator activity / ubiquitin-like protein conjugating enzyme binding / ubiquitin-specific protease binding
Processes
activation of protein kinase B activity / adult locomotory behavior / autophagy / cellular response to glyoxal / cellular response to hydrogen peroxide / cellular response to oxidative stress / detoxification of copper ion / detoxification of mercury ion / dopamine uptake involved in synaptic transmission / enzyme active site formation via L-cysteine sulfinic acid / glycolate biosynthetic process / glyoxal catabolic process / hydrogen peroxide metabolic process / inflammatory response / lactate biosynthetic process / membrane depolarization / membrane hyperpolarization / methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione / mitochondrion organization / negative regulation of apoptotic process / negative regulation of cell death / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / negative regulation of death-inducing signaling complex assembly / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / negative regulation of extrinsic apoptotic signaling pathway / negative regulation of gene expression / negative regulation of hydrogen peroxide-induced cell death / negative regulation of hydrogen peroxide-induced neuron death / negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway / negative regulation of neuron apoptotic process / negative regulation of neuron death / negative regulation of oxidative stress-induced cell death / negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / negative regulation of protein acetylation / negative regulation of protein binding / negative regulation of protein export from nucleus / negative regulation of protein K48-linked deubiquitination / negative regulation of protein kinase activity / negative regulation of protein phosphorylation / negative regulation of protein sumoylation / negative regulation of protein ubiquitination / negative regulation of TRAIL-activated apoptotic signaling pathway / negative regulation of ubiquitin-protein transferase activity / negative regulation of ubiquitin-specific protease activity / positive regulation of androgen receptor activity / positive regulation of dopamine biosynthetic process / positive regulation of gene expression / positive regulation of interleukin-8 production / positive regulation of L-dopa biosynthetic process / positive regulation of L-dopa decarboxylase activity / positive regulation of mitochondrial electron transport, NADH to ubiquinone / positive regulation of mitophagy / positive regulation of oxidative phosphorylation uncoupler activity / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of peptidyl-serine phosphorylation / positive regulation of protein homodimerization activity / positive regulation of protein kinase B signaling / positive regulation of protein localization to nucleus / positive regulation of pyrroline-5-carboxylate reductase activity / positive regulation of reactive oxygen species biosynthetic process / positive regulation of sequence-specific DNA binding transcription factor activity / positive regulation of superoxide dismutase activity / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription regulatory region DNA binding / positive regulation of tyrosine 3-monooxygenase activity / protein deglycosylation / protein stabilization / Ras protein signal transduction / regulation of androgen receptor signaling pathway / regulation of fibril organization / regulation of inflammatory response / regulation of mitochondrial membrane potential / regulation of neuron apoptotic process / single fertilization
Components
axon / cell body / chromatin / cytoplasm / cytosol / endoplasmic reticulum / extracellular exosome / membrane raft / mitochondrial intermembrane space / mitochondrial matrix / mitochondrion / nucleus / plasma membrane / PML body
General Function
Ubiquitin-specific protease binding
Specific Function
Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress (PubMed:18626009). Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (PubMed:23792957).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010695|Protein deglycase DJ-1 (PARK7)
ATGGCTTCCAAAAGAGCTCTGGTCATCCTGGCTAAAGGAGCAGAGGAAATGGAGACGGTC
ATCCCTGTAGATGTCATGAGGCGAGCTGGGATTAAGGTCACCGTTGCAGGCCTGGCTGGA
AAAGACCCAGTACAGTGTAGCCGTGATGTGGTCATTTGTCCTGATGCCAGCCTTGAAGAT
GCAAAAAAAGAGGGACCATATGATGTGGTGGTTCTACCAGGAGGTAATCTGGGCGCACAG
AATTTATCTGAGTCTGCTGCTGTGAAGGAGATACTGAAGGAGCAGGAAAACCGGAAGGGC
CTGATAGCCGCCATCTGTGCAGGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGA
AGTAAAGTTACAACACACCCTCTTGCTAAAGACAAAATGATGAATGGAGGTCATTACACC
TACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACC
AGCTTCGAGTTTGCGCTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAA
GTGAAGGCTCCACTTGTTCTTAAAGACTAG
Chromosome Location
1
Locus
1p36.33-p36.12
External Identifiers
ResourceLink
UniProtKB IDQ99497
UniProtKB Entry NamePARK7_HUMAN
GenBank Protein ID30038760
GenBank Gene IDD61380
GenAtlas IDPARK7
HGNC IDHGNC:16369
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails