P2X purinoceptor 4
Details
- Name
- P2X purinoceptor 4
- Synonyms
- ATP receptor
- P2X4
- Purinergic receptor
- Gene Name
- P2RX4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009820|P2X purinoceptor 4 MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC MKKRLYYREKKYKYVEDYEQGLASELDQ
- Number of residues
- 388
- Molecular Weight
- 43368.725
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / cadherin binding / copper ion binding / drug binding / extracellular ATP-gated cation channel activity / protein homodimerization activity / purinergic nucleotide receptor activity / receptor binding / zinc ion bindingProcessesapoptotic signaling pathway / calcium ion transport / cellular response to ATP / endothelial cell activation / excitatory postsynaptic potential / ion transmembrane transport / membrane depolarization / negative regulation of cardiac muscle hypertrophy / neuronal action potential / nitric oxide biosynthetic process / positive regulation of calcium ion transport / positive regulation of calcium ion transport into cytosol / positive regulation of calcium-mediated signaling / positive regulation of nitric oxide biosynthetic process / positive regulation of prostaglandin secretion / protein homooligomerization / purinergic nucleotide receptor signaling pathway / regulation of blood pressure / regulation of cardiac muscle contraction / regulation of sodium ion transport / relaxation of cardiac muscle / response to ATP / response to fluid shear stress / sensory perception of pain / signal transduction / tissue homeostasis / transport / vasodilationComponentsapical part of cell / cell junction / dendritic spine / extracellular exosome / integral component of nuclear inner membrane / integral component of plasma membrane / lysosomal membrane / membrane / neuronal cell body / perinuclear region of cytoplasm / plasma membrane / postsynaptic density / terminal bouton
- General Function
- Zinc ion binding
- Specific Function
- Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
- Pfam Domain Function
- P2X_receptor (PF00864)
- Transmembrane Regions
- 34-54 339-359
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0013934|P2X purinoceptor 4 (P2RX4) ATGGCGGGCTGCTGCGCCGCGCTGGCGGCCTTCCTGTTCGAGTACGACACGCCGCGCATC GTGCTCATCCGCAGCCGCAAAGTGGGGCTCATGAACCGCGCCGTGCAACTGCTCATCCTG GCCTACGTCATCGGGTGCTACCATCCCCATTTGGCAGAAGTGGAAATGGAGTCCCCTAGA AGGTGGGTGTTTGTGTGGGAAAAGGGCTACCAGGAAACTGACTCCGTGGTCAGCTCCGTT ACGACCAAGGTCAAGGGCGTGGCTGTGACCAACACTTCTAAACTTGGATTCCGGATCTGG GATGTGGCGGATTATGTGATACCAGCTCAGGAGGAAAACTCCCTCTTCGTCATGACCAAC GTGATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACT GTGTGTAAATCAGATGCCAGCTGTACTGCCGGCTCTGCCGGCACCCACAGCAACGGAGTC TCAACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGG TGCCCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAAC TTCACTCTTTTGGTTAAGAACAACATCTGGTATCCCAAATTTAATTTCAGCAAGAGGAAT ATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGAT CCCTTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAG GACATGGCCGTGGAGGGAGGCATCATGGGCATCCAGGTCAACTGGGACTGCAACCTGGAC AGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTT GAGCACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAGTACTACAGAGACCTGGCT GGCAACGAGCAGCGCACGCTCATCAAGGCCTATGGCATCCGCTTCGACATCATTGTGTTT GGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCA CTGCTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGA CTCTACTATCGGGAGAAGAAATATAAATATGTGGAAGATTACGAGCAGGGTCTTGCTAGT GAGCTGGACCAGTGA
- Chromosome Location
- 12
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q99571 UniProtKB Entry Name P2RX4_HUMAN HGNC ID HGNC:8535 - General References
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