Prohibitin-2
Details
- Name
- Prohibitin-2
- Synonyms
- B-cell receptor-associated protein BAP37
- BAP
- D-prohibitin
- REA
- Repressor of estrogen receptor activity
- Gene Name
- PHB2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049728|Prohibitin-2 MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQ DTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSM YQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILD DVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGE ALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK
- Number of residues
- 299
- Molecular Weight
- 33296.06
- Theoretical pI
- Not Available
- GO Classification
- Functionsamide binding / estrogen receptor binding / protein C-terminus binding / protein N-terminus bindingProcessesmammary gland alveolus development / mammary gland branching involved in thelarche / mitochondrion organization / negative regulation of apoptotic process / negative regulation of intracellular estrogen receptor signaling pathway / negative regulation of mammary gland epithelial cell proliferation / negative regulation of sequence-specific DNA binding transcription factor activity / negative regulation of transcription, DNA-templated / positive regulation of cell cycle G1/S phase transition / positive regulation of ERK1 and ERK2 cascade / positive regulation of exit from mitosis / positive regulation of sequence-specific DNA binding transcription factor activity / protein import into nucleus, translocation / protein stabilization / regulation of branching involved in mammary gland duct morphogenesis / sister chromatid cohesion / transcription, DNA-templatedComponentscell periphery / cell surface / cytoplasm / extracellular exosome / mitochondrial inner membrane / mitochondrial outer membrane / mitochondrion / nuclear matrix / nucleus / protein complex
- General Function
- Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
- Specific Function
- Amide binding
- Pfam Domain Function
- Band_7 (PF01145)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion inner membrane
- Gene sequence
>lcl|BSEQ0049729|Prohibitin-2 (PHB2) ATGGCCCAGAACTTGAAGGACTTGGCGGGACGGCTGCCCGCCGGGCCCCGGGGCATGGGC ACGGCCCTGAAGCTGTTGCTGGGGGCCGGCGCCGTGGCCTACGGTGTGCGCGAATCTGTG TTCACCGTGGAAGGCGGGCACAGAGCCATCTTCTTCAATCGGATCGGTGGAGTGCAGCAG GACACTATCCTGGCCGAGGGCCTTCACTTCAGGATCCCTTGGTTCCAGTACCCCATTATC TATGACATTCGGGCCAGACCTCGAAAAATCTCCTCCCCTACAGGCTCCAAAGACCTACAG ATGGTGAATATCTCCCTGCGAGTGTTGTCTCGACCCAATGCTCAGGAGCTTCCTAGCATG TACCAGCGCCTAGGGCTGGACTACGAGGAACGAGTGTTGCCGTCCATTGTCAACGAGGTG CTCAAGAGTGTGGTGGCCAAGTTCAATGCCTCACAGCTGATCACCCAGCGGGCCCAGGTA TCCCTGTTGATCCGCCGGGAGCTGACAGAGAGGGCCAAGGACTTCAGCCTCATCCTGGAT GATGTGGCCATCACAGAGCTGAGCTTTAGCCGAGAGTACACAGCTGCTGTAGAAGCCAAA CAAGTGGCCCAGCAGGAGGCCCAGCGGGCCCAATTCTTGGTAGAAAAAGCAAAGCAGGAA CAGCGGCAGAAAATTGTGCAGGCCGAGGGTGAGGCCGAGGCTGCCAAGATGCTTGGAGAA GCACTGAGCAAGAACCCTGGCTACATCAAACTTCGCAAGATTCGAGCAGCCCAGAATATC TCCAAGACGATCGCCACATCACAGAATCGTATCTATCTCACAGCTGACAACCTTGTGCTG AACCTACAGGATGAAAGTTTCACCAGGGGAAGTGACAGCCTCATCAAGGGTAAGAAATGA
- Chromosome Location
- 12
- Locus
- 12p13.31
- External Identifiers
Resource Link UniProtKB ID Q99623 UniProtKB Entry Name PHB2_HUMAN HGNC ID HGNC:30306 - General References
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