Lysophosphatidic acid receptor 4
Details
- Name
- Lysophosphatidic acid receptor 4
- Synonyms
- G-protein coupled receptor 23
- GPR23
- LPA receptor 4
- LPA4
- P2RY9
- P2Y purinoceptor 9
- P2Y5-like receptor
- P2Y9
- Purinergic receptor 9
- Gene Name
- LPAR4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052217|Lysophosphatidic acid receptor 4 MGDRRFIDFQFQDSNSSLRPRLGNATANNTCIVDDSFKYNLNGAVYSVVFILGLITNSVS LFVFCFRMKMRSETAIFITNLAVSDLLFVCTLPFKIFYNFNRHWPFGDTLCKISGTAFLT NIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTN VNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLILNVSCSSVVLRTLRKPATLSQI GTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVRSQAITNCFLERFAKIMYPITLCLA TLNCCFDPFIYYFTLESFQKSFYINAHIRMESLFKTETPLTTKPSLPAIQEEVSDQTTNN GGELMLESTF
- Number of residues
- 370
- Molecular Weight
- 41894.675
- Theoretical pI
- Not Available
- GO Classification
- FunctionsG protein-coupled receptor activity / lysophosphatidic acid binding / lysophosphatidic acid receptor activityProcessesG protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway / positive regulation of Rho protein signal transductionComponentscell / integral component of plasma membrane / intracellular membrane-bounded organelle / nuclear body / plasma membrane
- General Function
- Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
- Specific Function
- G protein-coupled receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 44-64 74-94 113-133 156-176 204-224 255-275 295-315
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052218|Lysophosphatidic acid receptor 4 (LPAR4) ATGGGTGACAGAAGATTCATTGACTTCCAATTCCAAGATTCAAATTCAAGCCTCAGACCC AGGTTGGGCAATGCTACTGCCAATAATACTTGCATTGTTGATGATTCCTTCAAGTATAAT CTCAATGGTGCTGTCTACAGTGTTGTATTCATCTTGGGTCTGATAACCAACAGTGTCTCT CTGTTTGTCTTCTGTTTCCGCATGAAAATGAGAAGTGAGACTGCTATTTTTATCACCAAT CTAGCTGTCTCTGATTTGCTTTTTGTCTGTACACTACCTTTTAAAATATTTTACAACTTC AACCGCCACTGGCCTTTTGGTGACACCCTCTGCAAGATCTCTGGAACTGCATTCCTTACC AACATCTATGGGAGCATGCTCTTTCTCACCTGTATTAGTGTGGATCGTTTCCTGGCCATT GTCTATCCTTTTCGATCTCGTACTATTAGGACTAGGAGGAATTCTGCCATTGTGTGTGCT GGTGTCTGGATCCTAGTCCTCAGTGGCGGTATTTCAGCCTCTTTGTTTTCCACCACTAAT GTCAACAATGCAACCACCACCTGCTTTGAAGGCTTCTCCAAACGTGTCTGGAAGACTTAT TTATCCAAGATCACAATATTTATTGAAGTTGTTGGGTTTATCATTCCTCTAATATTGAAT GTCTCTTGCTCTTCTGTGGTGCTGAGAACTCTTCGCAAGCCTGCTACTCTGTCTCAAATT GGGACCAATAAGAAAAAAGTACTGAAAATGATCACAGTACATATGGCAGTCTTTGTGGTA TGCTTTGTACCCTACAACTCTGTCCTCTTCTTGTATGCCCTGGTGCGCTCCCAAGCTATT ACTAATTGCTTTTTGGAAAGATTTGCAAAGATCATGTACCCAATCACCTTGTGCCTTGCA ACTCTGAACTGTTGTTTTGACCCTTTCATCTATTACTTCACCCTTGAATCCTTTCAGAAG TCCTTCTACATCAATGCCCACATCAGAATGGAGTCCCTGTTTAAGACTGAAACACCTTTG ACCACAAAGCCTTCCCTTCCAGCTATTCAAGAGGAAGTGAGTGATCAAACAACAAATAAT GGTGGTGAATTAATGCTAGAATCCACCTTTTAG
- Chromosome Location
- X
- Locus
- Xq21.1
- External Identifiers
Resource Link UniProtKB ID Q99677 UniProtKB Entry Name LPAR4_HUMAN HGNC ID HGNC:4478 - General References
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