Thioredoxin reductase 3
Details
- Name
- Thioredoxin reductase 3
- Synonyms
- 1.8.1.9
- Tgr
- Thioredoxin and glutathione reductase
- Thioredoxin reductase TR2
- Trxr3
- Gene Name
- Txnrd3
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0052692|Thioredoxin reductase 3 MEKPPSPPPPPRAQTSPGLGKVGVLPNRRLGAVRGGLMSSPPGRRARLASPGTSRPSSEA REELRRRLRDLIEGNRVMIFSKSYCPHSTRVKELFSSLGVVYNILELDQVDDGASVQEVL TEISNQKTVPNIFVNKVHVGGCDRTFQAHQNGLLQKLLQDDSAHDYDLIIIGGGSGGLSC AKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLMHQAALLGHALQDAKKYG WEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVNSFGEFVDLHKIKATNKKG QETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGCTLVVGASYVGLECAG FLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPILVQQLEKGLPGKL KVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVP HVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDYINIPTTVFTPLEYGCCGLSE EKAIEMYKKENLEVYHTLFWPLEWTVAGRDNNTCYAKIICNKFDNERVVGFHLLGPNAGE ITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG
- Number of residues
- 652
- Molecular Weight
- 71318.475
- Theoretical pI
- Not Available
- GO Classification
- Functionsflavin adenine dinucleotide binding / glutathione oxidoreductase activity / thioredoxin-disulfide reductase activityProcessesblastocyst formation / cell differentiation / cell redox homeostasis / glutathione metabolic process / spermatogenesisComponentscytoplasm / cytosol / endoplasmic reticulum / mitochondrion / nucleoplasm
- General Function
- Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.
- Specific Function
- Flavin adenine dinucleotide binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052693|Thioredoxin reductase 3 (Txnrd3) CTGGAGAAGCCACCGTCCCCGCCGCCGCCTCCTCGGGCGCAGACCTCGCCCGGGCTGGGG AAGGTTGGAGTCCTCCCCAACCGCCGCCTGGGTGCTGTCCGTGGCGGCCTCATGTCGTCG CCACCCGGCCGCCGCGCCCGCCTGGCCTCCCCTGGGACCAGCCGCCCGTCTTCTGAGGCC CGCGAGGAGCTGCGGCGCCGCCTGCGGGACCTCATCGAGGGCAACAGGGTGATGATCTTC AGCAAGAGTTACTGTCCACACAGCACGCGGGTTAAGGAACTCTTTTCGTCCTTGGGAGTG GTCTATAACATCCTGGAACTTGATCAAGTTGATGACGGGGCCAGTGTTCAGGAAGTGCTG ACAGAAATCAGTAACCAGAAAACGGTGCCCAATATTTTTGTGAATAAAGTGCACGTGGGT GGATGTGACCGAACTTTCCAGGCACATCAGAATGGTTTACTGCAGAAGCTCCTCCAAGAT GACTCGGCTCATGATTACGACCTCATCATCATCGGCGGGGGTTCTGGCGGCCTCTCTTGT GCCAAGGAAGCTGCCAACTTGGGAAAGAAGGTCATGGTGCTAGACTTTGTGGTCCCATCG CCTCAGGGCACGACCTGGGGCCTTGGCGGCACCTGTGTGAACGTAGGCTGTATTCCAAAG AAGCTGATGCATCAGGCAGCCCTCCTGGGGCATGCTTTGCAAGATGCCAAGAAATATGGC TGGGAGTATAACCAGCAGGTGAAGCACAACTGGGAGGCCATGACAGAAGCTATCCAGAGC CACATTGGCTCCTTGAACTGGGGCTACAGGGTAACCCTTCGGGAGAAAGGCGTGACCTAT GTCAACTCCTTCGGGGAGTTTGTGGACCTGCATAAAATAAAGGCAACCAATAAGAAAGGG CAGGAAACGTTTTACACGGCTTCGAAGTTTGTCATAGCAACAGGTGAAAGGCCTCGGTAC TTGGGAATCCAGGGAGATAAAGAGTACTGTATTACGAGTGACGACCTGTTCTCTCTGCCA TACTGCCCGGGATGTACATTAGTCGTAGGCGCTTCTTATGTTGGTCTGGAGTGTGCGGGC TTTTTGGCTGGTTTGGGGTTAGATGTGACAGTCATGGTACGCTCCGTCCTTCTTCGTGGC TTTGATCAAGAAATGGCAGAGAAAGTGGGATCCTACCTGGAACAACAAGGTGTCAAGTTC CAAAGGAAATTCACCCCCATTTTGGTTCAACAGTTGGAGAAAGGTTTACCAGGAAAATTG AAAGTCGTGGCTAAGTCCACCGAAGGACCGGAAACAGTAGAAGGGATATACAACACGGTT TTGTTAGCAATTGGTCGTGACTCCTGTACAAGGAAAATAGGGCTGGAGAAGATCGGGGTC AAAATCAATGAGAAGAATGGCAAAATACCAGTAAACGATGTGGAGCAGACCAACGTGCCT CATGTTTATGCTATTGGGGACATACTGGACGGCAAACCAGAGCTCACCCCCGTTGCCATA CAGGCAGGCAAGCTGCTAGCTCGAAGACTCTTTGGGGTCTCTTTAGAAAAGTGTGATTAT ATTAACATCCCAACAACGGTGTTCACACCTCTGGAATATGGCTGTTGTGGACTGTCGGAA GAGAAAGCCATCGAAATGTATAAAAAAGAGAATCTGGAAGTGTATCACACCTTGTTTTGG CCTCTCGAGTGGACAGTTGCTGGCAGAGACAACAACACCTGTTATGCAAAGATAATCTGC AACAAATTCGACAACGAACGTGTGGTGGGATTTCACCTTCTGGGGCCAAATGCTGGTGAA ATCACGCAGGGATTTGCAGCTGCAATGAAATGTGGGCTCACGAAGCAGCTACTGGATGAT ACCATTGGAATCCACCCCACCTGTGGTGAGGTATTCACAACATTGGAAATCACAAAGTCC TCAGGGCTGGACATTACTCAGAAAGGCTGCTGAGGCTAG
- Chromosome Location
- 6
- Locus
- 6 D1
- External Identifiers
Resource Link UniProtKB ID Q99MD6 UniProtKB Entry Name TRXR3_MOUSE - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details