Serine/threonine-protein kinase RIO2

Details

Name
Serine/threonine-protein kinase RIO2
Synonyms
  • 2.7.11.1
  • RIO kinase 2
  • RIO2
Gene Name
RIOK2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051936|Serine/threonine-protein kinase RIO2
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHK
LIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQF
ALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID
YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESD
HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEV
SASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLE
ESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEK
NRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTR
TLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNI
KSSLEAASFWGE
Number of residues
552
Molecular Weight
63282.565
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / metal ion binding / protein serine/threonine kinase activity
Processes
cell cycle / maturation of SSU-rRNA / positive regulation of ribosomal small subunit export from nucleus / positive regulation of rRNA processing / protein autophosphorylation / regulation of mitotic metaphase/anaphase transition / ribosomal small subunit biogenesis / rRNA processing
Components
cytoplasm / cytosol / nucleoplasm / preribosome, small subunit precursor
General Function
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051937|Serine/threonine-protein kinase RIO2 (RIOK2)
ATGGGGAAAGTGAATGTGGCCAAGTTGCGTTACATGAGCCGAGATGACTTCAGGGTCTTG
ACCGCGGTTGAAATGGGCATGAAGAACCATGAAATTGTTCCCGGCAGTTTGATTGCTTCT
ATAGCCAGCCTTAAACATGGTGGCTGTAATAAAGTTTTAAGAGAATTAGTGAAACATAAA
CTCATAGCTTGGGAGCGTACCAAAACTGTCCAGGGCTATCGGTTGACAAATGCAGGATAT
GATTACCTAGCTTTGAAAACACTTTCTTCTAGGCAAGTAGTTGAGTCTGTTGGAAACCAG
ATGGGTGTTGGCAAAGAATCAGATATTTACATTGTTGCAAATGAAGAAGGACAACAATTT
GCATTAAAGCTTCACAGACTAGGAAGAACCTCGTTTCGAAATTTGAAAAACAAACGCGAT
TATCATAAACATAGGCACAATGTGTCATGGCTATATTTATCTCGTCTCTCTGCCATGAAG
GAATTTGCCTATATGAAGGCATTGTATGAGAGGAAATTTCCAGTTCCAAAGCCAATTGAT
TACAATCGTCATGCAGTGGTCATGGAACTCATAAATGGTTATCCACTATGTCAGATACAC
CATGTTGAAGATCCTGCATCAGTATATGATGAAGCTATGGAACTAATTGTCAAACTTGCA
AATCATGGGCTGATTCATGGAGATTTTAATGAATTTAATCTCATTTTGGATGAAAGTGAC
CATATCACCATGATTGATTTTCCACAGATGGTTTCAACTTCTCATCCCAATGCTGAGTGG
TATTTTGACAGAGATGTTAAATGCATTAAAGATTTCTTTATGAAACGTTTCAGCTACGAA
AGTGAGCTTTTTCCAACTTTTAAGGATATCAGGAGAGAAGACACTCTTGATGTGGAGGTT
TCTGCCAGTGGCTACACAAAGGAAATGCAGGCAGATGATGAACTGCTTCATCCATTAGGT
CCAGATGATAAAAATATTGAAACAAAAGAGGGATCTGAATTCTCATTTTCAGATGGAGAA
GTGGCAGAAAAAGCAGAGGTTTACGGGTCAGAAAATGAAAGTGAACGGAACTGTCTAGAA
GAATCAGAGGGCTGCTATTGCAGATCATCTGGAGACCCTGAACAAATAAAGGAAGACAGT
TTATCAGAAGAGAGTGCTGATGCACGGAGTTTTGAAATGACTGAATTCAATCAAGCTTTA
GAAGAAATAAAAGGGCAGGTTGTTGAAAACAACTCTGTAACTGAATTTTCTGAGGAGAAA
AACAGAACTGAAAATTACAACAGGCAAGATGGTCAGAGAGTTCAAGGAGGAGTCCCTGCT
GGCTCTGACGAGTATGAAGATGAATGCCCTCATCTAATTGCCTTGTCGTCATTAAATAGA
GAATTCAGGCCTTTCAGAGATGAAGAAAATGTGGGAGCTATGAATCAGTATAGAACAAGA
ACTCTGAGTATCACTTCTTCAGGCAGTGCTGTAAGCTGTTCAACAATTCCTCCAGAACTG
GTGAAACAGAAGGTGAAACGTCAGTTGACAAAACAGCAAAAATCAGCTGTCAGACGTCGA
TTGCAGAAAGGAGAAGCAAATATATTTACCAAGCAACGTAGGGAAAACATGCAAAATATC
AAATCAAGTTTGGAAGCAGCCAGCTTTTGGGGAGAATAA
Chromosome Location
5
Locus
5q15
External Identifiers
ResourceLink
UniProtKB IDQ9BVS4
UniProtKB Entry NameRIOK2_HUMAN
HGNC IDHGNC:18999
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails