Lysine-specific demethylase 5D
Details
- Name
- Lysine-specific demethylase 5D
- Synonyms
- 1.14.11.-
- H-Y
- Histocompatibility Y antigen
- Histone demethylase JARID1D
- HY
- HYA
- JARID1D
- Jumonji/ARID domain-containing protein 1D
- KIAA0234
- Protein SmcY
- SMCY
- Gene Name
- KDM5D
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004347|Lysine-specific demethylase 5D MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI EEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHP FDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYG PGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTM QLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHI NADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMK MLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYN FAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEM FIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVC LSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRS FEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTEL RVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGV EVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAEL QELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWI ADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKN SCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEG EQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQC VSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLP EGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATAC DPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIR APLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALE RRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDH SPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL
- Number of residues
- 1539
- Molecular Weight
- 174071.34
- Theoretical pI
- 5.66
- GO Classification
- FunctionsDNA binding / histone demethylase activity (H3-K4 specific) / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors / zinc ion bindingProcesseschromatin organization / histone H3-K4 demethylationComponentsnucleoplasm
- General Function
- Zinc ion binding
- Specific Function
- Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0011599|Lysine-specific demethylase 5D (KDM5D) ATGGAACCGGGGTGTGACGAGTTCCTGCCGCCACCGGAGTGCCCGGTTTTTGAGCCTAGC TGGGCTGAATTCCAAGACCCGCTTGGCTACATTGCGAAAATAAGGCCCATAGCAGAGAAG TCTGGCATCTGCAAAATCCGCCCACCCGCGGATTGGCAGCCTCCTTTTGCAGTAGAAGTT GACAATTTCAGATTTACTCCTCGCGTCCAAAGGCTAAATGAACTGGAGGCCCAAACTAGA GTGAAATTGAACTATTTGGATCAGATTGCAAAATTCTGGGAAATTCAAGGCTCCTCTTTA AAGATTCCCAATGTGGAGCGGAAGATCTTGGACCTCTACAGCCTTAGTAAGATTGTGATT GAGGAAGGTGGCTATGAAGCCATCTGCAAGGATCGTCGGTGGGCTCGAGTTGCCCAGCGT CTCCACTACCCACCAGGCAAAAACATTGGCTCCCTGCTACGATCACATTACGAACGCATT ATTTACCCCTATGAAATGTTTCAGTCTGGAGCCAACCATGTGCAATGTAACACACACCCG TTTGACAATGAGGTAAAAGATAAGGAATACAAGCCCCACAGCATCCCCCTTAGACAGTCT GTGCAGCCTTCAAAGTTCAGCAGCTACAGTCGACGGGCAAAAAGGCTACAGCCTGATCCA GAGCCTACAGAGGAGGACATTGAGAAGCATCCAGAGCTAAAGAAGTTACAGATATATGGG CCAGGTCCCAAAATGATGGGCTTGGGCCTTATGGCTAAGGATAAGGATAAGACTGTGCAT AAGAAAGTCACATGCCCCCCAACTGTTACGGTGAAGGATGAGCAAAGTGGAGGTGGGAAC GTGTCATCAACATTGCTCAAGCAGCACTTGAGCCTAGAGCCCTGCACTAAGACAACCATG CAACTTCGAAAGAATCACAGCAGTGCCCAGTTTATTGACTCATATATTTGCCAAGTATGC TCCCGTGGGGATGAAGATGATAAGCTTCTTTTCTGTGATGGCTGTGATGACAATTACCAC ATCTTCTGCTTGTTACCACCCCTTCCTGAAATCCCCAGAGGCATCTGGAGGTGCCCAAAA TGTATCTTGGCGGAGTGTAAACAGCCTCCTGAAGCTTTTGGATTTGAACAGGCTACCCAG GAGTACAGTTTGCAGAGTTTTGGTGAAATGGCTGATTCCTTCAAGTCCGACTACTTCAAC ATGCCTGTACATATGGTGCCTACAGAACTTGTAGAGAAGGAATTCTGGAGGCTGGTGAGC AGCATTGAGGAAGACGTGACAGTTGAATATGGAGCTGATATTCATTCCAAAGAATTTGGC AGTGGCTTTCCTGTCAGCAATAGCAAACAAAACTTATCTCCTGAGGAGAAGAGACAAAGT CTCACTGTGTTGACCAGGCTGATCTCAAGCTTCTGGGCTCAAGCAGTCCTCCCACCTTGG CCTCCCAAAGTGTTGGGATTACAGGAGTATGCGACCAGTGGTTGGAACCTGAATGTGATG CCAGTGCTAGATCAGTCTGTTCTCTGTCACATCAATGCAGACATCTCAGGCATGAAGGTG CCCTGGCTGTACGTGGGCATGGTTTTCTCAGCATTTTGTTGGCATATTGAGGATCACTGG AGTTACTCTATTAACTATCTGCATTGGGGTGAGCCGAAGACCTGGTATGGTGTACCCTCC CTGGCAGCAGAGCATTTGGAGGAGGTGATGAAGATGCTGACACCTGAGCTGTTTGATAGC CAGCCTGATCTCCTACACCAGCTTGTCACTCTCATGAATCCCAACACTTTGATGTCCCAT GGTGTGCCAGTTGTCCGCACAAACCAGTGTGCAGGGGAGTTTGTCATCACTTTTCCTCGT GCTTACCACAGTGGTTTTAACCAAGGCTACAATTTTGCTGAAGCTGTCAACTTTTGTACT GCTGACTGGCTACCTGCTGGACGCCAGTGCATTGAACACTACCGCCGGCTCCGGCGCTAT TGTGTCTTCTCCCACGAGGAGCTCATCTGCAAGATGGCTGCCTTCCCAGAGACGTTGGAT CTCAATCTAGCAGTAGCTGTGCACAAGGAGATGTTCATTATGGTTCAGGAGGAGCGACGT CTACGAAAGGCCCTTTTGGAGAAGGGCGTCACGGAGGCTGAGCGAGAGGCTTTTGAGCTG CTCCCAGATGATGAACGCCAGTGCATCAAGTGCAAGACCACGTGCTTCTTGTCAGCCCTG GCCTGCTACGACTGCCCAGATGGCCTTGTATGCCTTTCCCACATCAATGACCTCTGCAAG TGCTCTAGTAGCCGACAGTACCTCCGGTATCGGTACACCTTGGATGAGCTCCCCACCATG CTGCATAAACTGAAGATTCGGGCTGAGTCTTTTGACACCTGGGCCAACAAAGTGCGAGTG GCCTTGGAGGTGGAGGATGGCCGTAAACGCAGCTTTGAAGAGCTAAGGGCACTGGAGTCT GAGGCTCGTGAGAGGAGGTTTCCTAATAGTGAGCTGCTTCAGCGACTGAAGAACTGCCTG AGTGAGGTGGAGGCTTGTATTGCTCAAGTCCTGGGGCTGGTCAGTGGTCAGGTGGCCAGG ATGGACACTCCACAGCTGACCTTGACTGAACTCCGGGTCCTTCTTGAGCAGATGGGCAGC CTGCCCTGTGCCATGCATCAGATTGGGGATGTCAAGGATGTCCTGGAACAGGTGGAGGCC TATCAAGCTGAGGCTCGTGAGGCTCTGGCCACACTGCCCTCTAGTCCAGGGCTATTGCGG TCCCTGTTGGAGAGGGGGCAGCAGCTGGGTGTAGAGGTGCCTGAAGCCCATCAGCTTCAG CAGCAGGTGGAGCAGGCGCAATGGCTAGATGAAGTGAAGCAGGCCCTGGCCCCTTCTGCT CACAGGGGCTCTCTGGTCATCATGCAGGGGCTTTTGGTTATGGGTGCCAAGATAGCCTCC AGCCCTTCTGTGGACAAGGCCCGGGCTGAGCTGCAAGAACTACTGACCATTGCAGAGCGC TGGGAAGAAAAGGCTCATTTCTGCCTGGAGGCCAGGCAGAAGCATCCACCAGCCACATTG GAAGCCATAATTCGTGAGACAGAAAACATCCCTGTTCACCTGCCTAACATCCAGGCTCTC AAAGAAGCTCTGACTAAGGCACAAGCTTGGATTGCTGATGTGGATGAGATCCAAAATGGT GACCACTACCCCTGTCTAGATGACTTGGAGGGCCTGGTGGCTGTGGGCCGGGACCTGCCT GTGGGGCTGGAAGAGCTGAGACAGCTAGAGCTGCAGGTATTGACAGCACATTCCTGGAGA GAGAAGGCCTCCAAGACCTTTCTCAAGAAGAATTCTTGCTACACACTGCTTGAGGTGCTT TGCCCGTGTGCAGACGCTGGCTCAGACAGCACCAAGCGTAGCCGGTGGATGGAGAAGGCG CTGGGGTTGTACCAGTGTGACACAGAGCTGCTGGGGCTGTCTGCACAGGACCTCAGAGAC CCAGGCTCTGTGATTGTGGCCTTCAAGGAAGGGGAACAGAAGGAGAAGGAGGGTATCCTG CAGCTGCGTCGCACCAACTCAGCCAAGCCCAGTCCACTGGCACCATCCCTCATGGCCTCT TCTCCGACTTCTATCTGTGTGTGTGGGCAGGTGCCAGCTGGGGTGGGAGTTCTGCAGTGT GACCTGTGTCAGGACTGGTTCCATGGGCAGTGTGTGTCAGTGCCCCATCTCCTCACCTCT CCAAAGCCCAGTCTCACTTCATCTCCACTGCTAGCCTGGTGGGAATGGGACACAAAATTC CTGTGTCCACTGTGTATGCGCTCACGACGGCCACGCCTAGAGACAATCCTAGCCTTGCTG GTTGCCCTGCAGAGGCTGCCCGTGCGGCTGCCTGAGGGTGAGGCCCTTCAGTGTCTCACA GAGAGGGCCATTGGCTGGCAAGACCGTGCCAGAAAGGCTCTGGCCTCTGAAGATGTGACT GCTCTGTTGCGACAGCTGGCTGAGCTTCGCCAACAGCTACAGGCCAAACCCAGACCAGAG GAGGCCTCAGTCTACACTTCAGCCACTGCCTGTGACCCTATCAGAGAAGGCAGTGGCAAC AATATTTCTAAGGTCCAAGGGCTGCTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAAC ATGGCTCCAGGAAAGGGCTCTGACCTGGAGCTACTGTCCTCACTGTTGCCGCAGTTGACT GGCCCTGTGTTGGAGCTGCCTGAGGCAATCCGGGCTCCCCTGGAGGAGCTCATGATGGAA GGGGACCTGCTTGAGGTGACCCTGGATGAGAACCACAGCATCTGGCAGCTGCTGCAGGCT GGACAGCCTCCAGACCTGGACAGAATTCGCACACTTCTGGAGCTGGAAAAATTTGAACAT CAAGGGAGTCGGACAAGGAGCCGGGCTCTGGAGAGGCGACGGCGGCGGCAGAAGGTGGAT CAGGGTAGAAACGTTGAGAATCTTGTTCAACAGGAGCTTCAGTCAAAAAGGGCTCGGAGC TCAGGGATTATGTCTCAGGTGGGCCGAGAAGAAGAACATTATCAGGAGAAAGCAGACCGT GAAAATATGTTCCTGACACCTTCCACAGACCACAGCCCTTTCTTGAAAGGAAACCAAAAT AGCTTACAACACAAGGATTCAGGCTCTTCAGCTGCTTGTCCTTCTTTAATGCCTTTGCTA CAACTCTCCTACTCTGATGAGCAACAGTTGTGA
- Chromosome Location
- Y
- Locus
- Yq11|Yq11
- External Identifiers
Resource Link UniProtKB ID Q9BY66 UniProtKB Entry Name KDM5D_HUMAN GenBank Protein ID 1661016 GenBank Gene ID U52191 GenAtlas ID JARID1D HGNC ID HGNC:11115 - General References
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