Dendritic cell-specific transmembrane protein

Details

Name
Dendritic cell-specific transmembrane protein
Synonyms
  • DC-STAMP
  • Dendrocyte-expressed seven transmembrane protein
  • FIND
  • IL-four-induced protein
  • TM7SF4
  • Transmembrane 7 superfamily member 4
Gene Name
DCSTAMP
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052649|Dendritic cell-specific transmembrane protein
MGIWTSGTDIFLSLWEIYVSPRSPGWMDFIQHLGVCCLVALISVGLLSVAACWFLPSIIA
AAASWIITCVLLCCSKHARCFILLVFLSCGLREGRNALIAAGTGIVILGHVENIFHNFKG
LLDGMTCNLRAKSFSIHFPLLKKYIEAIQWIYGLATPLSVFDDLVSWNQTLAVSLFSPSH
VLEAQLNDSKGEVLSVLYQMATTTEVLSSLGQKLLAFAGLSLVLLGTGLFMKRFLGPCGW
KYENIYITRQFVQFDERERHQQRPCVLPLNKEERRKYVIIPTFWPTPKERKNLGLFFLPI
LIHLCIWVLFAAVDYLLYRLIFSVSKQFQSLPGFEVHLKLHGEKQGTQDIIHDSSFNISV
FEPNCIPKPKFLLSETWVPLSVILLILVMLGLLSSILMQLKILVSASFYPSVERKRIQYL
HAKLLKKRSKQPLGEVKRRLSLYLTKIHFWLPVLKMIRKKQMDMASADKS
Number of residues
470
Molecular Weight
53392.035
Theoretical pI
Not Available
GO Classification
Processes
cellular response to interleukin-4 / cellular response to macrophage colony-stimulating factor stimulus / cellular response to tumor necrosis factor / membrane fusion / myeloid dendritic cell differentiation / negative regulation of cell growth / osteoclast differentiation / osteoclast fusion / positive regulation of bone resorption / positive regulation of macrophage fusion / positive regulation of monocyte differentiation
Components
cell surface / endoplasmic reticulum membrane / endoplasmic reticulum-Golgi intermediate compartment membrane / endosome membrane / integral component of endoplasmic reticulum membrane / integral component of membrane / plasma membrane
General Function
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
35-55 58-78 98-118 210-230 293-313 377-397
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052650|Dendritic cell-specific transmembrane protein (DCSTAMP)
ATGGGTATCTGGACCTCAGGCACTGATATCTTCCTAAGTCTTTGGGAGATTTACGTGTCT
CCAAGAAGCCCCGGATGGATGGACTTTATCCAGCATTTGGGAGTTTGCTGTTTGGTTGCT
CTTATTTCAGTGGGCCTCCTGTCTGTGGCCGCCTGCTGGTTTCTGCCATCAATCATAGCG
GCCGCTGCCTCCTGGATTATCACGTGTGTTCTGCTGTGTTGCTCCAAGCATGCACGATGT
TTTATTCTTCTTGTCTTTCTCTCTTGTGGCCTGCGTGAAGGCAGGAATGCTTTGATTGCA
GCTGGCACAGGGATCGTCATCTTGGGACACGTAGAAAATATTTTTCACAACTTTAAAGGT
CTCCTAGATGGTATGACTTGCAACCTAAGGGCAAAGAGCTTTTCCATACATTTTCCACTT
TTGAAAAAATATATTGAGGCAATTCAGTGGATTTATGGCCTTGCCACTCCACTAAGTGTA
TTTGATGACCTTGTTTCTTGGAACCAGACCCTGGCAGTCTCTCTTTTCAGTCCCAGCCAT
GTCCTGGAGGCACAGCTAAATGACAGCAAAGGGGAAGTCCTGAGCGTCTTGTACCAGATG
GCAACAACCACAGAGGTGTTGTCCTCCCTGGGTCAGAAGCTACTTGCCTTTGCAGGGCTT
TCGCTCGTCCTGCTTGGCACTGGCCTCTTCATGAAGCGATTTTTGGGCCCTTGTGGTTGG
AAGTATGAAAACATCTACATCACCAGACAATTTGTTCAGTTTGATGAAAGGGAGAGACAT
CAACAGAGGCCCTGTGTGCTCCCGCTGAATAAGGAGGAAAGGAGGAAGTATGTCATCATC
CCGACTTTCTGGCCGACTCCTAAAGAAAGGAAAAACCTGGGGCTGTTTTTCCTCCCCATA
CTTATCCATCTCTGCATCTGGGTGCTGTTTGCAGCTGTAGATTATCTGCTGTATCGGCTC
ATTTTCTCAGTGAGCAAGCAGTTTCAAAGCTTGCCAGGGTTTGAGGTTCACTTGAAACTG
CACGGAGAGAAACAAGGAACTCAAGATATTATCCATGATTCTTCCTTTAATATATCTGTG
TTTGAACCCAACTGTATCCCAAAACCAAAATTCCTTCTATCTGAGACCTGGGTTCCTCTC
AGTGTTATTCTTTTGATATTAGTGATGCTGGGACTGTTGTCCTCTATCCTTATGCAACTT
AAAATCCTGGTGTCAGCATCTTTCTACCCCAGCGTGGAGAGGAAGCGCATCCAATATCTG
CATGCAAAGCTGCTTAAAAAAAGATCAAAGCAGCCGCTGGGAGAAGTCAAAAGACGGCTG
AGTCTCTATCTTACAAAGATTCATTTCTGGCTTCCAGTCCTGAAAATGATTAGGAAGAAG
CAAATGGACATGGCAAGTGCAGACAAGTCATGA
Chromosome Location
8
Locus
8q22.3
External Identifiers
ResourceLink
UniProtKB IDQ9H295
UniProtKB Entry NameDCSTP_HUMAN
HGNC IDHGNC:18549
General References
  1. Hartgers FC, Vissers JL, Looman MW, van Zoelen C, Huffine C, Figdor CG, Adema GJ: DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. Eur J Immunol. 2000 Dec;30(12):3585-90. doi: 10.1002/1521-4141(200012)30:12<3585::AID-IMMU3585>3.0.CO;2-Y. [Article]
  2. Staege H, Brauchlin A, Schoedon G, Schaffner A: Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages. Immunogenetics. 2001 Mar;53(2):105-13. doi: 10.1007/s002510100306. [Article]
  3. Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Eleveld-Trancikova D, Triantis V, Moulin V, Looman MW, Wijers M, Fransen JA, Lemckert AA, Havenga MJ, Figdor CG, Janssen RA, Adema GJ: The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. J Leukoc Biol. 2005 Mar;77(3):337-43. doi: 10.1189/jlb.0804441. Epub 2004 Dec 15. [Article]
  6. Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer MA, Looman MW, Hendriks IA, Jansen BJ, Adema GJ: DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. Mol Immunol. 2010 Jul;47(11-12):1963-73. doi: 10.1016/j.molimm.2010.04.019. Epub 2010 May 23. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails