Mitochondrial folate transporter/carrier
Details
- Name
- Mitochondrial folate transporter/carrier
- Synonyms
- MFT
- MFTC
- Solute carrier family 25 member 32
- Gene Name
- SLC25A32
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010514|Mitochondrial folate transporter/carrier MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRP KYNGILHCLTTIWKLDGLRGLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEA TEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVR GLYKGFVPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVA ATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVY ENVSHFLLDLREKRK
- Number of residues
- 315
- Molecular Weight
- 35406.83
- Theoretical pI
- 9.79
- GO Classification
- Functionsfolic acid transporter activityProcessesfolic acid metabolic process / folic acid transport / glycine metabolic process / mitochondrial transport / small molecule metabolic process / vitamin metabolic process / water-soluble vitamin metabolic processComponentsintegral component of membrane / mitochondrial inner membrane
- General Function
- Folic acid transporter activity
- Specific Function
- Transports folate across the inner membranes of mitochondria.
- Pfam Domain Function
- Mito_carr (PF00153)
- Transmembrane Regions
- 26-43 89-106 123-143 186-203 227-243 281-300
- Cellular Location
- Mitochondrion inner membrane
- Gene sequence
>lcl|BSEQ0010515|Mitochondrial folate transporter/carrier (SLC25A32) ATGACGGGCCAGGGCCAGTCGGCGTCCGGGTCGTCGGCGTGGAGCACGGTATTCCGCCAC GTCCGGTATGAGAACCTGATAGCGGGCGTGAGCGGCGGCGTCTTATCCAACCTTGCGCTG CATCCGCTCGACCTCGTGAAGATCCGCTTCGCCGTGAGTGATGGATTGGAACTGAGACCG AAATATAATGGAATTTTACATTGCTTGACTACCATTTGGAAACTTGATGGACTACGGGGA CTTTATCAAGGAGTAACCCCAAATATATGGGGTGCAGGTTTATCCTGGGGACTCTACTTT TTCTTTTACAATGCCATCAAGTCATATAAAACAGAAGGAAGAGCTGAACGTTTAGAGGCA ACAGAATACCTTGTCTCAGCTGCTGAAGCTGGAGCCATGACCCTCTGCATTACAAACCCA TTATGGGTAACAAAAACTCGCCTTATGTTACAGTATGATGCTGTTGTTAACTCCCCACAC CGACAATATAAAGGAATGTTTGATACACTTGTGAAAATATATAAGTATGAAGGTGTGCGT GGATTATATAAGGGATTTGTTCCTGGGCTGTTTGGAACATCGCATGGTGCCCTTCAGTTT ATGGCATATGAATTGCTGAAGTTGAAGTACAACCAGCATATCAATAGATTACCAGAAGCC CAGTTGAGCACAGTAGAATATATATCTGTTGCAGCACTATCCAAAATATTTGCTGTCGCA GCAACATACCCATATCAAGTCGTAAGAGCTCGTCTTCAGGATCAACACATGTTTTACAGT GGTGTAATAGATGTAATCACAAAGACATGGAGGAAAGAAGGCGTCGGTGGATTTTACAAG GGAATTGCTCCTAATTTGATTAGAGTGACTCCAGCCTGCTGTATTACCTTTGTGGTATAT GAAAACGTCTCACATTTTTTACTTGACCTTAGAGAAAAGAGAAAGTAA
- Chromosome Location
- 8
- Locus
- 8q22.3
- External Identifiers
Resource Link UniProtKB ID Q9H2D1 UniProtKB Entry Name MFTC_HUMAN GenBank Protein ID 11545417 GenBank Gene ID AF283645 GenAtlas ID SLC25A32 HGNC ID HGNC:29683 - General References
- Titus SA, Moran RG: Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. J Biol Chem. 2000 Nov 24;275(47):36811-7. [Article]
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