Sodium-coupled neutral amino acid transporter 1
Details
- Name
- Sodium-coupled neutral amino acid transporter 1
- Synonyms
- Amino acid transporter A1
- ATA1
- N-system amino acid transporter 2
- NAT2
- SAT1
- SNAT1
- Solute carrier family 38 member 1
- System A amino acid transporter 1
- System N amino acid transporter 1
- Gene Name
- SLC38A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052307|Sodium-coupled neutral amino acid transporter 1 MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEK KKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSIN LLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFL MGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKK FQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELK DRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAV IVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGV VGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACS SSSDEGH
- Number of residues
- 487
- Molecular Weight
- 54047.02
- Theoretical pI
- Not Available
- GO Classification
- Functionsamino acid / amino acid transmembrane transporter activity / L-amino acid transmembrane transporter activity / neutral amino acid transmembrane transporter activityProcessesamino acid transmembrane transport / amino acid transport / neurotransmitter uptake / neutral amino acid transportComponentsextracellular exosome / integral component of membrane / integral component of plasma membrane / plasma membrane
- General Function
- Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
- Specific Function
- Amino acid transmembrane transporter activity
- Pfam Domain Function
- Aa_trans (PF01490)
- Transmembrane Regions
- 75-97 113-133 148-168 189-211 217-237 276-296 313-333 351-371 394-414 417-437 453-473
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052308|Sodium-coupled neutral amino acid transporter 1 (SLC38A1) ATGATGCATTTCAAAAGTGGACTCGAATTAACTGAGTTGCAAAACATGACAGTGCCCGAG GATGATAACATTAGCAATGACTCCAATGATTTCACCGAAGTAGAAAATGGTCAGATAAAT AGCAAGTTTATTTCTGATCGTGAAAGTAGAAGAAGTCTCACAAACAGCCATTTGGAAAAA AAGAAGTGTGATGAGTATATTCCAGGTACAACCTCCTTAGGCATGTCTGTTTTTAACCTA AGCAACGCCATTATGGGCAGTGGGATTTTGGGACTCGCCTTTGCCCTGGCAAACACTGGA ATCCTACTTTTTCTGGTACTTTTGACTTCAGTGACATTGCTGTCTATATATTCAATAAAC CTCCTATTGATCTGTTCAAAAGAAACAGGCTGCATGGTGTATGAAAAGCTGGGGGAACAA GTCTTTGGCACCACAGGGAAGTTCGTAATCTTTGGAGCCACCTCTCTACAGAACACTGGA GCAATGCTGAGCTACCTCTTCATCGTAAAAAATGAACTACCCTCTGCCATAAAGTTTCTA ATGGGAAAGGAAGAGACATTTTCAGCCTGGTACGTGGATGGCCGCGTTCTGGTGGTGATA GTTACCTTTGGCATAATTCTCCCTCTGTGTCTCTTGAAGAACTTAGGGTATCTTGGCTAT ACTAGTGGATTTTCCTTGAGCTGTATGGTTTTTTTCCTAATTGTGGTTATTTACAAGAAA TTTCAAATTCCCTGCATTGTTCCAGAGCTAAATTCAACAATAAGTGCTAATTCAACAAAT GCTGACACGTGTACGCCAAAATATGTTACCTTCAATTCAAAGACCGTGTATGCTTTACCC ACCATTGCATTTGCATTTGTTTGCCACCCGTCAGTCCTGCCAATTTACAGTGAGCTTAAA GACCGATCACAGAAAAAAATGCAGATGGTTTCAAACATCTCCTTTTTCGCCATGTTTGTT ATGTACTTCTTGACTGCCATTTTTGGCTACTTGACATTCTATGACAACGTGCAGTCCGAC CTCCTTCACAAATATCAGAGTAAAGATGACATTCTCATCCTGACAGTGCGGCTGGCTGTC ATTGTTGCTGTGATCCTCACAGTGCCGGTGTTATTTTTCACGGTTCGTTCATCTTTATTT GAACTGGCTAAGAAAACAAAGTTTAATTTATGTCGTCATACCGTGGTTACCTGCATACTC TTGGTTGTTATCAACTTGTTGGTGATCTTCATACCCTCCATGAAGGATATTTTTGGAGTC GTAGGAGTTACATCTGCTAACATGCTTATTTTCATTCTTCCTTCATCTCTTTATTTAAAA ATCACAGACCAGGATGGAGATAAAGGAACTCAAAGAATTTGGGCTGCCCTTTTCTTGGGC CTGGGGGTGTTGTTCTCCTTGGTCAGCATTCCCTTGGTCATCTATGACTGGGCCTGCTCA TCGAGTAGTGACGAAGGCCACTGA
- Chromosome Location
- 12
- Locus
- 12q13.11
- External Identifiers
Resource Link UniProtKB ID Q9H2H9 UniProtKB Entry Name S38A1_HUMAN HGNC ID HGNC:13447 - General References
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