Tyrosine-protein kinase Srms

Details

Name
Tyrosine-protein kinase Srms
Synonyms
  • 2.7.10.2
  • C20orf148
Gene Name
SRMS
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051957|Tyrosine-protein kinase Srms
MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY
DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW
YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY
LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY
FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI
VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD
GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF
TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL
HAIHRCHP
Number of residues
488
Molecular Weight
54506.255
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / non-membrane spanning protein tyrosine kinase activity / protein tyrosine kinase activity / receptor binding
Processes
cell differentiation / innate immune response / negative regulation of signal transduction / peptidyl-tyrosine autophosphorylation / regulation of cell proliferation / transmembrane receptor protein tyrosine kinase signaling pathway
Components
cytoplasm / cytosol / extrinsic component of cytoplasmic side of plasma membrane
General Function
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051958|Tyrosine-protein kinase Srms (SRMS)
ATGGAGCCGTTCCTCAGGAGGCGGCTGGCCTTCCTGTCCTTCTTCTGGGACAAGATCTGG
CCGGCGGGCGGCGAGCCGGACCATGGCACCCCCGGGTCCCTGGACCCCAACACTGACCCA
GTGCCCACGCTCCCCGCCGAGCCTTGCAGCCCCTTCCCTCAGCTCTTCCTTGCGCTCTAT
GACTTCACGGCGCGGTGTGGCGGGGAGCTGAGTGTCCGCCGCGGGGACAGGCTCTGTGCC
CTCGAAGAGGGGGGCGGCTACATCTTCGCACGCAGGCTTTCGGGCCAGCCCAGCGCCGGG
CTCGTGCCCATCACCCACGTGGCCAAGGCTTCTCCTGAGACGCTCTCAGACCAACCCTGG
TACTTTAGCGGGGTCAGTCGGACCCAGGCACAGCAGCTGCTCCTCTCCCCACCCAACGAA
CCAGGGGCCTTCCTCATCCGGCCCAGCGAGAGCAGCCTCGGGGGCTACTCACTGTCAGTC
CGGGCCCAGGCCAAGGTCTGCCACTACCGGGTCTCCATGGCAGCTGATGGCAGCCTCTAC
CTGCAGAAGGGACGGCTCTTTCCCGGCCTGGAGGAGCTGCTCACCTACTACAAGGCCAAC
TGGAAGCTGATCCAGAACCCCCTGCTGCAGCCCTGCATGCCCCAGAAGGCCCCGAGGCAG
GACGTGTGGGAGCGGCCACACTCCGAATTCGCCCTTGGGAGGAAGCTGGGTGAAGGCTAC
TTTGGGGAGGTGTGGGAAGGCCTGTGGCTGGGCTCCCTGCCCGTGGCGATCAAGGTCATC
AAGTCAGCCAACATGAAGCTCACTGACCTCGCCAAGGAGATCCAGACACTGAAGGGCCTG
CGGCACGAGCGGCTCATCCGGCTGCACGCAGTGTGCTCGGGCGGGGAGCCTGTGTACATC
GTCACGGAACTCATGCGCAAGGGGAACCTGCAGGCCTTCCTGGGCACCCCCGAGGGCCGG
GCCCTGCGTCTGCCGCCACTCCTGGGCTTTGCCTGCCAGGTGGCTGAGGGCATGAGCTAC
CTGGAGGAGCAGCGCGTTGTGCACCGGGACTTGGCCGCCCGGAACGTGCTCGTGGACGAC
GGCCTGGCCTGCAAGGTGGCTGACTTCGGCCTGGCCCGGCTGCTCAAGGACGACATCTAC
TCCCCGAGCAGCAGCTCCAAGATCCCGGTCAAGTGGACAGCGCCTGAGGCGGCCAATTAT
CGTGTCTTCTCCCAGAAGTCAGACGTCTGGTCCTTCGGCGTCCTGCTGCACGAGGTTTTC
ACCTATGGCCAGTGTCCCTATGAAGGGATGACCAACCACGAGACGCTGCAGCAGATCATG
CGAGGGTACCGGCTGCCGCGCCCGGCTGCCTGCCCGGCGGAGGTCTACGTGCTCATGCTG
GAGTGCTGGAGGAGCAGCCCCGAGGAACGGCCCTCCTTCGCCACGCTGCGGGAGAAGCTG
CACGCCATCCACAGATGCCACCCCTGA
Chromosome Location
20
Locus
20q13.33
External Identifiers
ResourceLink
UniProtKB IDQ9H3Y6
UniProtKB Entry NameSRMS_HUMAN
HGNC IDHGNC:11298
General References
  1. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
  2. Goel RK, Miah S, Black K, Kalra N, Dai C, Lukong KE: The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. FEBS J. 2013 Sep;280(18):4539-59. doi: 10.1111/febs.12420. Epub 2013 Aug 19. [Article]
  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails