Cytochrome P450 3A43

Details

Name
Cytochrome P450 3A43
Synonyms
  • 1.14.14.1
Gene Name
CYP3A43
UniProtKB Entry
Q9HB55Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0006840|Cytochrome P450 3A43
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
PILQPEKPIVLKVHLRDGITSGP
Number of residues
503
Molecular Weight
57669.21
Theoretical pI
8.25
GO Classification
Functions
estrogen 16-alpha-hydroxylase activity / testosterone 6-beta-hydroxylase activity
Processes
cytochrome metabolic process / oxidative demethylation / steroid metabolic process
General Function
Exhibits low testosterone 6-beta-hydroxylase activity
Specific Function
Aromatase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0012469|Cytochrome P450 3A43 (CYP3A43)
ATGGATCTCATTCCAAACTTTGCCATGGAAACATGGGTTCTTGTGGCTACCAGCCTGGTA
CTCCTCTATATTTATGGGACCCATTCACATAAACTTTTTAAGAAGCTGGGAATTCCTGGG
CCAACCCCTCTGCCTTTTCTGGGAACTATTTTGTTCTACCTTAGGAGGTCTCTGAATAAG
ATTCCCAGCTGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGCA
GGAGGATCACCTAAGGTCAGGAGTTCGAGACCAGCTTTGCCAACATGGGTCTTTGGAATT
TTGACAGAGAATGTAATGAAAAATACGGAGAAATGTGGGGCACTCTTTCCATTTCTTACC
CCAGTTTTTGAAGCCCTAAATATCGGTTTGTTTCCAAAAGATGTTACCCATTTTTTAAAA
AATTCCATTGAAAGGATGAAAGAAAGTCGCCTCAAAGATAAACAAAAGCATCGAGTAGAT
TTCTTTCAACAGATGATCGACTCCCAGAATTCCAAAGAAACAAAGTCCCATAAAGCTCTG
TCTGATCTGGAGCTTGTGGCCCAGTCAATTATCATCATTTTTGCTGCCTATGACACAACT
AGCACCACTCTCCCCTTCATTATGTATGAACTGGCCACTCACCCTGATGTCCAGCAGAAA
CTGCAGGAGGAGATTGACGCAGTTTTACCCAATAAGGCACCTGTCACCTACGATGCCCTG
GTACAGATGGAGTACCTTGACATGGTGGTGAATGAAACGCTCAGATTATTCCCAGTTGTT
AGTAGAGTTACGAGAGTCTGCAAGAAAGATATTGAAATCAATGGAGTGTTCATTCCCAAA
GGGTTAGCAGTGATGGTTCCAATCTATGCTCTTCACCATGACCCAAAGTACTGGACAGAG
CCTGAGAAGTTCTGCCCTGAAAGGTTCAGTAAGAAGAACAAGGACAGCATAGATCTTTAC
AGATACATACCTTTTGGAGCTGGACCCCGAAACTGCATTGGCATGAGGTTTGCTCTCACA
AACATAAAACTTGCTGTCATTAGAGCACTGCAGAACTTCTCCTTCAAACCTTGTAAAGAG
ACTCAGATCCCACTGAAATTAGACAATCTACCAATTCTTCAACCAGAAAAACCTATTGTT
CTAAAAGTGCACTTAAGAGATGGGATTACAAGTGGACCCTGA
Chromosome Location
7
Locus
7q22.1
External Identifiers
ResourceLink
UniProtKB IDQ9HB55
UniProtKB Entry NameCP343_HUMAN
GenBank Protein ID12642642
GenBank Gene IDAF319634
GeneCard IDCYP3A43
HGNC IDHGNC:17450
KEGG IDhsa:64816
NCBI Gene ID64816
General References
  1. Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG: cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol. 2001 Feb;59(2):386-92. [Article]
  2. Westlind A, Malmebo S, Johansson I, Otter C, Andersson TB, Ingelman-Sundberg M, Oscarson M: Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43. Biochem Biophys Res Commun. 2001 Mar;281(5):1349-55. [Article]
  3. Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics. 2001 Mar;11(2):111-21. [Article]
  4. Cauffiez C, Lo-Guidice JM, Chevalier D, Allorge D, Hamdan R, Lhermitte M, Lafitte JJ, Colombel JF, Libersa C, Broly F: First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. Hum Mutat. 2004 Jan;23(1):101. [Article]
  5. Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Finta C, Zaphiropoulos PG: Intergenic mRNA molecules resulting from trans-splicing. J Biol Chem. 2002 Feb 22;277(8):5882-90. Epub 2001 Nov 28. [Article]
  8. Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Cytochrome P450 3A43 (Humans)protein
primary
Cytochrome P450 3A Subfamily (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
TroleandomycinapprovedunknownenzymeinducerDetails
Dexamethasoneapproved, investigational, vet_approvedunknownenzymeinducerDetails
RifampinapprovedunknownenzymeinducerDetails
Testosteroneapproved, investigationalunknownenzymesubstrateDetails
Netupitantapproved, investigationalnoenzymesubstrateDetails
Daclatasvirapproved, investigationalunknownenzymesubstrateDetails
IdelalisibapprovednoenzymesubstrateinhibitorDetails
Oxymetholoneapproved, illicitunknownenzymeinhibitorDetails
Midostaurinapproved, investigationalunknownenzymeinducerDetails
ElbasvirapprovedunknownenzymesubstrateDetails
Rucaparibapproved, investigationalnoenzymeinhibitorDetails
Testosterone cypionateapprovedunknownenzymesubstrateDetails
Testosterone enanthateapprovedunknownenzymesubstrateDetails
Testosterone undecanoateapproved, investigationalunknownenzymesubstrateDetails
Dexamethasone acetateapproved, investigational, vet_approvedunknownenzymeinducerDetails
Fluvoxamineapproved, investigationalunknownenzymeinhibitorDetails
Thiopentalapproved, vet_approvedunknownenzymesubstrateDetails
DolutegravirapprovednoenzymesubstrateDetails
Midostaurinapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
RheinexperimentalunknownenzymeinhibitorDetails
Diacereinapproved, investigationalunknowntargetinhibitorDetails
MyrrhapprovedunknownenzymeinducerDetails
Naldemedineapproved, investigationalnoenzymesubstrateDetails
Pibrentasvirapproved, investigationalunknownenzymeinhibitorDetails
Glecaprevirapproved, investigationalunknownenzymesubstrateinhibitorDetails
Moxisylyteapproved, investigationalnoenzymesubstrateDetails
Omega-3-carboxylic acidsapproved, investigationalnoenzymesubstrateDetails
LopinavirapprovednoenzymeinhibitorDetails
Nefazodoneapproved, withdrawnnoenzymeinhibitorDetails
Ambroxol acefyllinateexperimental, investigationalnoenzymesubstrateDetails
MirodenafilinvestigationalunknownenzymesubstrateDetails
Elagolixapproved, investigationalnoenzymesubstrateDetails
Crizotinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Acalabrutinibapproved, investigationalunknownenzymesubstrateDetails
Brigatinibapproved, investigationalunknownenzymeinducerDetails
ForetinibinvestigationalunknownenzymesubstrateDetails
Lorlatinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
PhenelzineapprovedunknownenzymeinhibitorDetails
EthosuximideapprovedunknownenzymesubstrateDetails
Rifapentineapproved, investigationalunknownenzymeinducerDetails
Mebendazoleapproved, vet_approvedunknownenzymesubstrateDetails
Istradefyllineapproved, investigationalunknownenzymeinhibitorDetails
Olanzapineapproved, investigationalunknownenzymeinhibitorDetails
LoxoprofenapprovedunknownenzymesubstrateDetails
Prednisoneapproved, vet_approvedunknownenzymeinducerDetails
BudesonideapprovedunknownenzymesubstrateinducerDetails
Methylprednisoloneapproved, vet_approvedunknownenzymesubstrateinducerDetails
Lemborexantapproved, investigationalunknownenzymeinhibitorinducerDetails
Tazemetostatapproved, investigationalunknownenzymesubstrateDetails
Prednisolone phosphateapproved, vet_approvedunknownenzymeinducerDetails
Tucatinibapproved, investigationalunknownenzymesubstrateDetails
Zanubrutinibapproved, investigationalunknownenzymesubstrateDetails
Selpercatinibapproved, investigationalunknownenzymeinhibitorDetails
Remoxiprideapproved, withdrawnunknownenzymeinhibitorDetails
Risdiplamapproved, investigationalunknownenzymeinhibitorDetails
Lonafarnibapproved, investigationalnoenzymesubstrateinhibitorDetails
Relugolixapproved, investigationalunknownenzymesubstrateinducerDetails
Ursodeoxycholic acidapproved, investigationalunknownenzymeinducerDetails
Ebastineapproved, investigationalunknownenzymesubstrateDetails
Sotorasibapproved, investigationalunknownenzymesubstrateDetails
Quercetinexperimental, investigationalnoenzymeinhibitorDetails
Dextropropoxypheneapproved, illicit, investigational, withdrawnunknownenzymeinhibitorDetails
MethadoneapprovednoenzymeinhibitorDetails
Itraconazoleapproved, investigationalnoenzymeinhibitorDetails
Birch bark extractapproved, experimentalunknownenzymeinhibitorDetails
Letermovirapproved, investigationalnoenzymesubstrateinhibitorDetails