Casein kinase I isoform gamma-1

Details

Name
Casein kinase I isoform gamma-1
Synonyms
  • 2.7.11.1
  • CKI-gamma 1
Gene Name
CSNK1G1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008118|Casein kinase I isoform gamma-1
MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL
GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL
LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE
HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM
FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE
KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP
SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR
HK
Number of residues
422
Molecular Weight
48510.965
Theoretical pI
9.34
GO Classification
Functions
ATP binding / protein serine/threonine kinase activity
Processes
endocytosis / peptidyl-serine phosphorylation / regulation of cell shape / Wnt signaling pathway
Components
cytoplasm
General Function
Protein serine/threonine kinase activity
Specific Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0017391|Casein kinase I isoform gamma-1 (CSNK1G1)
ATGGACCATCCTAGTAGGGAAAAGGATGAAAGACAACGGACAACTAAACCCATGGCACAA
AGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTATGGTG
GGACCCAACTTCAGGGTTGGCAAGAAGATAGGATGTGGGAACTTCGGAGAGCTCAGATTA
GGTAAAAATCTCTACACCAATGAATATGTAGCAATCAAACTGGAACCAATAAAATCACGT
GCTCCACAGCTTCATTTAGAGTACAGATTTTATAAACAGCTTGGCAGTGCAGGTGAAGGT
CTCCCACAGGTGTATTACTTTGGACCATGTGGGAAATATAATGCCATGGTGCTGGAGCTC
CTTGGCCCTAGCTTGGAGGACTTGTTTGACCTCTGTGACCGAACATTTACTTTGAAGACG
GTGTTAATGATAGCCATCCAGCTGCTTTCTCGAATGGAATACGTGCACTCAAAGAACCTC
ATTTACCGAGATGTCAAGCCAGAGAACTTCCTGATTGGTCGACAAGGCAATAAGAAAGAG
CATGTTATACACATTATAGACTTTGGACTGGCCAAGGAATACATTGACCCCGAAACCAAA
AAACACATACCTTATAGGGAACACAAAAGTTTAACTGGAACTGCAAGATATATGTCTATC
AACACGCATCTTGGCAAAGAGCAAAGCCGGAGAGATGATTTGGAAGCCCTAGGCCATATG
TTCATGTATTTCCTTCGAGGCAGCCTCCCCTGGCAAGGACTCAAGGCTGACACATTAAAA
GAGAGATATCAAAAAATTGGTGACACCAAAAGGAATACTCCCATTGAAGCTCTCTGTGAG
AACTTTCCAGAGGAGATGGCAACCTACCTTCGATATGTCAGGCGACTGGACTTCTTTGAA
AAACCTGATTATGAGTATTTACGGACCCTCTTCACAGACCTCTTTGAAAAGAAAGGCTAC
ACCTTTGACTATGCCTATGATTGGGTTGGGAGACCTATTCCTACTCCAGTAGGGTCAGTT
CACGTAGATTCTGGTGCATCTGCAATAACTCGAGAAAGCCACACACATAGGGATCGGCCA
TCACAACAGCAGCCTCTTCGAAATCAGGTGGTTAGCTCAACCAATGGAGAGCTGAATGTT
GATGATCCCACGGGAGCCCACTCCAATGCACCAATCACAGCTCATGCCGAGGTGGAGGTA
GTGGAGGAAGCTAAGTGCTGCTGTTTCTTTAAGAGGAAAAGGAAGAAGACTGCTCAGCGC
CACAAGTGA
Chromosome Location
15
Locus
15q22.1-q22.31
External Identifiers
ResourceLink
UniProtKB IDQ9HCP0
UniProtKB Entry NameKC1G1_HUMAN
GenBank Protein ID11177010
GenBank Gene IDAB042563
HGNC IDHGNC:2454
General References
  1. Kusuda J, Hirai M, Tanuma R, Hashimoto K: Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy-terminal sequences. Cytogenet Cell Genet. 2000;90(3-4):298-302. [Article]
  2. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [Article]
  5. Meng Z, Capalbo L, Glover DM, Dunphy WG: Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Mol Biol Cell. 2011 Aug 15;22(16):2834-47. doi: 10.1091/mbc.E11-01-0048. Epub 2011 Jun 16. [Article]
  6. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB083252-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanolexperimentalunknownDetails