Casein kinase I isoform gamma-1
Details
- Name
- Casein kinase I isoform gamma-1
- Synonyms
- 2.7.11.1
- CKI-gamma 1
- Gene Name
- CSNK1G1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008118|Casein kinase I isoform gamma-1 MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR HK
- Number of residues
- 422
- Molecular Weight
- 48510.965
- Theoretical pI
- 9.34
- GO Classification
- FunctionsATP binding / protein serine/threonine kinase activityProcessesendocytosis / peptidyl-serine phosphorylation / regulation of cell shape / Wnt signaling pathwayComponentscytoplasm
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0017391|Casein kinase I isoform gamma-1 (CSNK1G1) ATGGACCATCCTAGTAGGGAAAAGGATGAAAGACAACGGACAACTAAACCCATGGCACAA AGGAGTGCACACTGCTCTCGACCATCTGGCTCCTCATCGTCCTCTGGGGTTCTTATGGTG GGACCCAACTTCAGGGTTGGCAAGAAGATAGGATGTGGGAACTTCGGAGAGCTCAGATTA GGTAAAAATCTCTACACCAATGAATATGTAGCAATCAAACTGGAACCAATAAAATCACGT GCTCCACAGCTTCATTTAGAGTACAGATTTTATAAACAGCTTGGCAGTGCAGGTGAAGGT CTCCCACAGGTGTATTACTTTGGACCATGTGGGAAATATAATGCCATGGTGCTGGAGCTC CTTGGCCCTAGCTTGGAGGACTTGTTTGACCTCTGTGACCGAACATTTACTTTGAAGACG GTGTTAATGATAGCCATCCAGCTGCTTTCTCGAATGGAATACGTGCACTCAAAGAACCTC ATTTACCGAGATGTCAAGCCAGAGAACTTCCTGATTGGTCGACAAGGCAATAAGAAAGAG CATGTTATACACATTATAGACTTTGGACTGGCCAAGGAATACATTGACCCCGAAACCAAA AAACACATACCTTATAGGGAACACAAAAGTTTAACTGGAACTGCAAGATATATGTCTATC AACACGCATCTTGGCAAAGAGCAAAGCCGGAGAGATGATTTGGAAGCCCTAGGCCATATG TTCATGTATTTCCTTCGAGGCAGCCTCCCCTGGCAAGGACTCAAGGCTGACACATTAAAA GAGAGATATCAAAAAATTGGTGACACCAAAAGGAATACTCCCATTGAAGCTCTCTGTGAG AACTTTCCAGAGGAGATGGCAACCTACCTTCGATATGTCAGGCGACTGGACTTCTTTGAA AAACCTGATTATGAGTATTTACGGACCCTCTTCACAGACCTCTTTGAAAAGAAAGGCTAC ACCTTTGACTATGCCTATGATTGGGTTGGGAGACCTATTCCTACTCCAGTAGGGTCAGTT CACGTAGATTCTGGTGCATCTGCAATAACTCGAGAAAGCCACACACATAGGGATCGGCCA TCACAACAGCAGCCTCTTCGAAATCAGGTGGTTAGCTCAACCAATGGAGAGCTGAATGTT GATGATCCCACGGGAGCCCACTCCAATGCACCAATCACAGCTCATGCCGAGGTGGAGGTA GTGGAGGAAGCTAAGTGCTGCTGTTTCTTTAAGAGGAAAAGGAAGAAGACTGCTCAGCGC CACAAGTGA
- Chromosome Location
- 15
- Locus
- 15q22.1-q22.31
- External Identifiers
Resource Link UniProtKB ID Q9HCP0 UniProtKB Entry Name KC1G1_HUMAN GenBank Protein ID 11177010 GenBank Gene ID AB042563 HGNC ID HGNC:2454 - General References
- Kusuda J, Hirai M, Tanuma R, Hashimoto K: Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy-terminal sequences. Cytogenet Cell Genet. 2000;90(3-4):298-302. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [Article]
- Meng Z, Capalbo L, Glover DM, Dunphy WG: Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Mol Biol Cell. 2011 Aug 15;22(16):2834-47. doi: 10.1091/mbc.E11-01-0048. Epub 2011 Jun 16. [Article]
- Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]