Alanine racemase, catabolic

Details

Name
Alanine racemase, catabolic
Synonyms
  • 5.1.1.1
Gene Name
dadX
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0019181|Alanine racemase, catabolic
MRPARALIDLQALRHNYRLAREATGARALAVIKADAYGHGAVRCAEALAAEADGFAVACI
EEGLELREAGIRQPILLLEGFFEASELELIVAHDFWCVVHCAWQLEAIERASLARPLNVW
LKMDSGMHRVGFFPEDFSAAHERLRASGKVAKIVMMSHFSRADELDCPRTEEQLAAFAAA
SQGLEGEISLRNSPAVLGWPKVPSDWVRPGILLYGATPFERAHPLADRLRPVMTLESKVI
SVRDLPAGEPVGYGARYSTERSQRIGVVAMGYADGYPRHAADGTLVFIDGKPGRLVGRVS
MDMLTVDLTDHPQAGLGSRVELWGPNVPVGALAAQFGSIPYQLLCNLKRVPRVYSGA
Number of residues
357
Molecular Weight
38914.32
Theoretical pI
6.85
GO Classification
Functions
alanine racemase activity / pyridoxal phosphate binding
Processes
alanine metabolic process
General Function
Pyridoxal phosphate binding
Specific Function
Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0019182|Alanine racemase, catabolic (dadX)
ATGCGCCCCGCCCGTGCCCTGATCGACCTGCAAGCCCTTCGTCACAACTATCGGCTGGCC
CGCGAGGCCACCGGCGCCCGTGCGCTCGCGGTGATCAAGGCGGACGCATACGGCCACGGC
GCGGTGCGCTGTGCCGAAGCGCTGGCGGCCGAGGCCGATGGCTTCGCCGTGGCCTGCATC
GAGGAGGGCCTGGAGCTGCGCGAGGCCGGTATCCGCCAGCCGATCCTGCTGCTGGAGGGC
TTCTTCGAGGCGTCCGAGCTGGAGCTGATCGTCGCCCACGACTTCTGGTGCGTGGTGCAT
TGCGCCTGGCAATTGGAGGCGATCGAACGCGCCAGCCTGGCCCGCCCGCTGAACGTCTGG
CTGAAGATGGATTCGGGCATGCACCGCGTCGGCTTCTTCCCCGAGGACTTCAGCGCCGCC
CACGAGCGCCTGCGGGCCAGCGGCAAGGTGGCGAAGATCGTGATGATGAGTCACTTCTCC
CGCGCCGACGAACTGGATTGCCCGCGCACCGAGGAACAGCTCGCCGCCTTCGCGGCCGCG
AGCCAGGGCCTGGAAGGCGAGATCAGCCTGCGCAATTCGCCAGCCGTGCTCGGCTGGCCG
AAGGTGCCCAGCGATTGGGTACGTCCGGGCATCCTGCTCTACGGAGCCACGCCGTTCGAG
CGCGCACATCCGCTGGCCGACCGCTTGCGCCCGGTGATGACCCTAGAATCGAAGGTGATC
AGCGTCCGCGACCTGCCGGCCGGCGAACCGGTCGGCTACGGCGCGCGCTACAGCACCGAG
CGTAGCCAGCGCATCGGCGTGGTCGCCATGGGCTACGCCGATGGCTATCCGCGCCACGCC
GCCGACGGCACCCTTGTGTTCATCGACGGCAAGCCGGGGCGCCTGGTTGGCCGGGTATCG
ATGGACATGCTCACCGTCGACCTTACCGACCATCCCCAGGCCGGGCTGGGCAGCCGGGTC
GAACTATGGGGCCCGAACGTGCCGGTCGGCGCCCTGGCGGCGCAGTTCGGCAGCATTCCC
TACCAGCTGCTGTGCAACCTGAAAAGGGTGCCGCGCGTCTATTCCGGGGCTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9HTQ2
UniProtKB Entry NameALR2_PSEAE
GenBank Protein ID5690425
GenBank Gene IDAF165881
General References
  1. Strych U, Huang HC, Krause KL, Benedik MJ: Characterization of the alanine racemases from Pseudomonas aeruginosa PAO1. Curr Microbiol. 2000 Oct;41(4):290-4. [Article]
  2. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  3. LeMagueres P, Im H, Dvorak A, Strych U, Benedik M, Krause KL: Crystal structure at 1.45 A resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. Biochemistry. 2003 Dec 23;42(50):14752-61. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03252D-LysineexperimentalunknownDetails
DB03801Lysine Nz-Carboxylic AcidexperimentalunknownDetails