Lipid A deacylase PagL

Details

Name
Lipid A deacylase PagL
Synonyms
  • 3.1.1.77
  • LPS 3-O-deacylase PagL
  • Outer membrane enzyme PagL
  • PhoP/PhoQ-activated gene product L
Gene Name
pagL
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0012793|Lipid A deacylase PagL
MKKLLPLAVLAALSSVHVASAQAADVSAAVGATGQSGMTYRLGLSWDWDKSWWQTSTGRL
TGYWDAGYTYWEGGDEGAGKHSLSFAPVFVYEFAGDSIKPFIEAGIGVAAFSGTRVGDQN
LGSSLNFEDRIGAGLKFANGQSVGVRAIHYSNAGLKQPNDGIESYSLFYKIPI
Number of residues
173
Molecular Weight
18393.44
Theoretical pI
6.25
GO Classification
Functions
acyloxyacyl hydrolase activity / protein homodimerization activity
Processes
lipid A metabolic process / lipopolysaccharide metabolic process
Components
cell outer membrane / integral component of membrane
General Function
Protein homodimerization activity
Specific Function
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety. Lacks fatty acyl chain-length specificity as removes both 3-OH C10 and 3-OH C14 fatty acids from lipid A.
Pfam Domain Function
Transmembrane Regions
29-32 34-49 57-71 74-89 91-93 96-98 101-115 118-128 139-148
Cellular Location
Cell outer membrane
Gene sequence
>lcl|BSEQ0012794|Lipid A deacylase PagL (pagL)
ATGAAGAAACTACTTCCGCTGGCCGTTCTGGCCGCACTTTCCTCCGTCCACGTGGCGTCC
GCCCAGGCGGCGGACGTCTCGGCCGCCGTCGGTGCGACCGGCCAGTCGGGCATGACCTAT
CGCCTGGGCCTGAGCTGGGATTGGGACAAGAGCTGGTGGCAGACCTCCACCGGGCGCCTG
ACCGGCTACTGGGATGCGGGCTACACCTATTGGGAAGGTGGCGATGAAGGCGCCGGCAAG
CATTCGCTGTCGTTCGCTCCGGTATTCGTCTACGAGTTCGCCGGCGACTCGATCAAGCCA
TTCATCGAGGCCGGTATCGGCGTGGCGGCGTTCTCCGGCACCCGTGTCGGCGACCAGAAC
CTGGGTTCCTCCCTGAACTTCGAAGACCGCATCGGCGCCGGCCTGAAGTTCGCCAACGGC
CAGTCGGTCGGCGTTCGGGCGATCCACTATTCCAACGCCGGCCTGAAACAGCCGAACGAC
GGTATCGAGTCCTACAGCCTGTTCTACAAGATCCCGATCTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9HVD1
UniProtKB Entry NamePAGL_PSEAE
GenBank Protein ID9945819
GenBank Gene IDAE004091
General References
  1. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  2. Geurtsen J, Steeghs L, Hove JT, van der Ley P, Tommassen J: Dissemination of lipid A deacylases (pagL) among gram-negative bacteria: identification of active-site histidine and serine residues. J Biol Chem. 2005 Mar 4;280(9):8248-59. Epub 2004 Dec 20. [Article]
  3. Ernst RK, Adams KN, Moskowitz SM, Kraig GM, Kawasaki K, Stead CM, Trent MS, Miller SI: The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. J Bacteriol. 2006 Jan;188(1):191-201. [Article]
  4. Rutten L, Geurtsen J, Lambert W, Smolenaers JJ, Bonvin AM, de Haan A, van der Ley P, Egmond MR, Gros P, Tommassen J: Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7071-6. Epub 2006 Apr 21. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails