Lipid A deacylase PagL
Details
- Name
- Lipid A deacylase PagL
- Synonyms
- 3.1.1.77
- LPS 3-O-deacylase PagL
- Outer membrane enzyme PagL
- PhoP/PhoQ-activated gene product L
- Gene Name
- pagL
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Amino acid sequence
>lcl|BSEQ0012793|Lipid A deacylase PagL MKKLLPLAVLAALSSVHVASAQAADVSAAVGATGQSGMTYRLGLSWDWDKSWWQTSTGRL TGYWDAGYTYWEGGDEGAGKHSLSFAPVFVYEFAGDSIKPFIEAGIGVAAFSGTRVGDQN LGSSLNFEDRIGAGLKFANGQSVGVRAIHYSNAGLKQPNDGIESYSLFYKIPI
- Number of residues
- 173
- Molecular Weight
- 18393.44
- Theoretical pI
- 6.25
- GO Classification
- Functionsacyloxyacyl hydrolase activity / protein homodimerization activityProcesseslipid A metabolic process / lipopolysaccharide metabolic processComponentscell outer membrane / integral component of membrane
- General Function
- Protein homodimerization activity
- Specific Function
- Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety. Lacks fatty acyl chain-length specificity as removes both 3-OH C10 and 3-OH C14 fatty acids from lipid A.
- Pfam Domain Function
- PagL (PF09411)
- Transmembrane Regions
- 29-32 34-49 57-71 74-89 91-93 96-98 101-115 118-128 139-148
- Cellular Location
- Cell outer membrane
- Gene sequence
>lcl|BSEQ0012794|Lipid A deacylase PagL (pagL) ATGAAGAAACTACTTCCGCTGGCCGTTCTGGCCGCACTTTCCTCCGTCCACGTGGCGTCC GCCCAGGCGGCGGACGTCTCGGCCGCCGTCGGTGCGACCGGCCAGTCGGGCATGACCTAT CGCCTGGGCCTGAGCTGGGATTGGGACAAGAGCTGGTGGCAGACCTCCACCGGGCGCCTG ACCGGCTACTGGGATGCGGGCTACACCTATTGGGAAGGTGGCGATGAAGGCGCCGGCAAG CATTCGCTGTCGTTCGCTCCGGTATTCGTCTACGAGTTCGCCGGCGACTCGATCAAGCCA TTCATCGAGGCCGGTATCGGCGTGGCGGCGTTCTCCGGCACCCGTGTCGGCGACCAGAAC CTGGGTTCCTCCCTGAACTTCGAAGACCGCATCGGCGCCGGCCTGAAGTTCGCCAACGGC CAGTCGGTCGGCGTTCGGGCGATCCACTATTCCAACGCCGGCCTGAAACAGCCGAACGAC GGTATCGAGTCCTACAGCCTGTTCTACAAGATCCCGATCTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9HVD1 UniProtKB Entry Name PAGL_PSEAE GenBank Protein ID 9945819 GenBank Gene ID AE004091 - General References
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- Geurtsen J, Steeghs L, Hove JT, van der Ley P, Tommassen J: Dissemination of lipid A deacylases (pagL) among gram-negative bacteria: identification of active-site histidine and serine residues. J Biol Chem. 2005 Mar 4;280(9):8248-59. Epub 2004 Dec 20. [Article]
- Ernst RK, Adams KN, Moskowitz SM, Kraig GM, Kawasaki K, Stead CM, Trent MS, Miller SI: The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. J Bacteriol. 2006 Jan;188(1):191-201. [Article]
- Rutten L, Geurtsen J, Lambert W, Smolenaers JJ, Bonvin AM, de Haan A, van der Ley P, Egmond MR, Gros P, Tommassen J: Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7071-6. Epub 2006 Apr 21. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details