Phosphoheptose isomerase

Details

Name

Phosphoheptose isomerase

Synonyms

• 5.3.1.28
• Sedoheptulose 7-phosphate isomerase

Gene Name

gmhA

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Amino acid sequence

>lcl|BSEQ0020572|Phosphoheptose isomerase
MDMQHRIRQLFQASIETKQQALEVLPPYIEQASLVMVNALLNEGKILSCGNGGSAGDAQH
FSSELLNRFERERPSLPAVALTTDSSTITSIANDYSYNEVFSKQIRALGQPGDVLLAIST
SGNSANVIQAIQAAHDREMLVVALTGRDGGGMASLLLPEDVEIRVPSKITARIQEVHLLA
IHCLCDLIDRQLFGSEE

Number of residues

197

Molecular Weight

21413.11

Theoretical pI

4.72

GO Classification

Functions

carbohydrate binding / D-sedoheptulose 7-phosphate isomerase activity / zinc ion binding

Processes

D-glycero-D-manno-heptose 7-phosphate biosynthetic process / lipopolysaccharide core region biosynthetic process

Components

cytoplasm

General Function

Zinc ion binding

Specific Function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Pfam Domain Function

• SIS_2 (PF13580)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0020573|Phosphoheptose isomerase (gmhA)
ATGGACATGCAACACCGTATCCGCCAGCTCTTCCAGGCCAGCATCGAGACCAAGCAGCAG
GCGCTGGAAGTACTGCCTCCCTATATCGAGCAAGCCAGCCTGGTGATGGTCAATGCGCTG
CTCAACGAGGGCAAGATCCTCTCCTGCGGCAATGGCGGCTCGGCCGGCGATGCCCAGCAC
TTCTCCTCCGAACTGCTCAACCGCTTCGAGCGCGAACGTCCGAGCCTCCCGGCCGTGGCC
CTGACCACCGACAGCTCGACCATCACCTCGATCGCCAACGACTACAGCTACAACGAAGTC
TTCTCCAAGCAGATCCGCGCCCTGGGCCAGCCGGGCGACGTCCTGCTGGCGATTTCCACC
AGCGGCAATTCGGCCAACGTGATCCAGGCCATCCAGGCGGCCCACGACCGCGAGATGCTG
GTGGTCGCCCTGACCGGCCGCGACGGTGGCGGCATGGCTTCGCTGCTGCTGCCGGAAGAC
GTGGAGATCCGCGTTCCTTCCAAGATCACCGCACGCATCCAGGAAGTCCACCTGCTGGCC
ATCCACTGCCTCTGCGACCTGATCGACCGCCAACTGTTCGGGAGTGAAGAATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9HVZ0
UniProtKB Entry Name	GMHA_PSEAE
GenBank Protein ID	9950658
GenBank Gene ID	AE004091

General References

1. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
2. Valvano MA, Messner P, Kosma P: Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides. Microbiology. 2002 Jul;148(Pt 7):1979-89. [Article]
3. Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS: Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. J Biol Chem. 2008 Feb 1;283(5):2835-45. Epub 2007 Dec 3. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB02470	D-Glycero-D-Mannopyranose-7-Phosphate	experimental	unknown		Details