Thioredoxin reductase 1, cytoplasmic

Details

Name

Thioredoxin reductase 1, cytoplasmic

Synonyms

• 1.8.1.9
• Thioredoxin reductase TR1
• TR
• Trxr1

Gene Name

Txnrd1

Organism

Mouse

Amino acid sequence

>lcl|BSEQ0052696|Thioredoxin reductase 1, cytoplasmic
MPVDDCWLYFPASRGRTFVQTVWVAPTCPNCCWFPGFLPPVPRPPHVPRVLLRGPRGAVL
PASRPSKTLPSSSQTPCPTDPCICPPPSTPDSRQEKNTQSELPNKKGQLQKLPTMNGSKD
PPGSYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIP
KKLMHQAALLGQALKDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVV
YENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSL
PYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIK
FIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVG
VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCD
YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKII
CNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVTK
RSGGDILQSGCUG

Number of residues

613

Molecular Weight

67083.29

Theoretical pI

Not Available

GO Classification

Functions

flavin adenine dinucleotide binding / identical protein binding / mercury ion binding / NAD(P)H oxidase H2O2-forming activity / selenate reductase activity / thioredoxin-disulfide reductase activity

Processes

benzene-containing compound metabolic process / cell population proliferation / cell redox homeostasis / gastrulation / hydrogen peroxide catabolic process / mesoderm formation / NADPH oxidation / positive regulation of cell death / response to oxidative stress / selenocysteine metabolic process

Components

cytoplasm / cytosol / fibrillar center / mitochondrion / neuronal cell body / nucleoplasm / nucleus

General Function

Not Available

Specific Function

Flavin adenine dinucleotide binding

Pfam Domain Function

• Pyr_redox_2 (PF07992)
• Pyr_redox_dim (PF02852)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0052697|Thioredoxin reductase 1, cytoplasmic (Txnrd1)
ATGCCAGTTGATGACTGCTGGCTGTACTTCCCAGCTTCTCGAGGTAGAACCTTTGTGCAG
ACTGTCTGGGTGGCACCCACTTGCCCCAACTGTTGCTGGTTTCCAGGTTTTCTCCCTCCA
GTCCCCCGGCCACCACATGTGCCCCGTGTGCTGCTGAGGGGCCCTCGTGGGGCTGTGCTT
CCTGCTTCACGTCCCTCCAAGACACTCCCCTCCTCATCCCAGACGCCCTGTCCTACTGAC
CCCTGTATCTGCCCTCCACCCTCCACACCTGATAGTAGGCAGGAAAAAAATACGCAATCT
GAGCTGCCGAACAAAAAAGGCCAACTTCAAAAGCTGCCAACAATGAATGGCTCCAAAGAT
CCCCCTGGGTCCTATGACTTCGACCTGATCATCATTGGAGGAGGCTCAGGAGGACTGGCA
GCAGCTAAGGAGGCAGCCAAATTTGACAAGAAAGTGCTGGTCTTGGATTTTGTCACACCG
ACTCCTCTTGGGACCAGATGGGGTCTCGGAGGAACGTGTGTGAATGTGGGTTGCATACCT
AAGAAGCTGATGCACCAGGCAGCTTTGCTCGGACAAGCTCTGAAAGACTCGCGCAACTAT
GGCTGGAAAGTCGAAGACACAGTGAAGCATGACTGGGAGAAAATGACGGAATCTGTGCAG
AGTCACATCGGCTCGCTGAACTGGGGCTACCGCGTAGCTCTCCGGGAGAAAAAGGTCGTC
TATGAGAATGCTTACGGGAGGTTCATTGGTCCTCACAGGATTGTGGCGACAAATAACAAA
GGTAAAGAAAAAATCTATTCAGCAGAGCGGTTCCTCATCGCCACAGGTGAGAGGCCCCGC
TACCTGGGCATCCCTGGAGACAAAGAGTACTGCATCAGCAGTGATGATCTTTTCTCCTTG
CCTTACTGCCCGGGGAAGACCCTAGTAGTTGGTGCATCCTATGTCGCCTTGGAATGTGCA
GGATTTCTGGCTGGTATCGGCTTAGACGTCACTGTAATGGTGCGGTCCATTCTCCTTAGA
GGATTTGACCAAGACATGGCCAACAAAATCGGTGAACACATGGAAGAACATGGTATCAAG
TTTATAAGGCAGTTCGTCCCAACGAAAATTGAACAGATCGAAGCAGGAACACCAGGCCGA
CTCAGGGTGACTGCTCAATCCACAAACAGCGAGGAGACCATAGAGGGCGAATTTAACACA
GTGTTGCTGGCGGTAGGAAGAGATTCTTGTACGAGAACTATTGGCTTAGAGACCGTGGGC
GTGAAGATAAACGAAAAAACCGGAAAGATACCCGTCACGGATGAAGAGCAGACCAATGTG
CCTTACATCTACGCCATCGGTGACATCCTGGAGGGGAAGCTAGAGCTGACTCCCGTAGCC
ATCCAGGCGGGGAGATTGCTGGCTCAGAGGCTGTATGGAGGCTCCAATGTCAAATGTGAC
TATGACAATGTCCCAACGACTGTATTTACTCCTTTGGAATATGGCTGTTGTGGCCTCTCT
GAAGAAAAAGCCGTAGAGAAATTTGGGGAAGAAAATATTGAAGTTTACCATAGTTTCTTT
TGGCCATTGGAATGGACAGTCCCATCCCGGGATAACAACAAATGTTATGCAAAAATAATC
TGCAACCTTAAAGACGATGAACGTGTCGTGGGCTTCCACGTGCTGGGTCCAAACGCTGGA
GAGGTGACGCAGGGCTTTGCGGCTGCGCTCAAGTGTGGGCTGACTAAGCAGCAGCTGGAC
AGCACCATCGGCATCCACCCGGTCTGTGCAGAGATATTCACAACGTTGTCAGTGACGAAG
CGCTCTGGGGGAGACATCCTCCAGTCTGGCTGCTGAGGTTAA

Chromosome Location

10

Locus

10 C1

External Identifiers

Resource	Link
UniProtKB ID	Q9JMH6
UniProtKB Entry Name	TRXR1_MOUSE

General References

1. Kawai H, Ota T, Suzuki F, Tatsuka M: Molecular cloning of mouse thioredoxin reductases. Gene. 2000 Jan 25;242(1-2):321-30. doi: 10.1016/s0378-1119(99)00498-9. [Article]
2. Sun QA, Zappacosta F, Factor VM, Wirth PJ, Hatfield DL, Gladyshev VN: Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing. J Biol Chem. 2001 Feb 2;276(5):3106-14. Epub 2000 Nov 1. [Article]
3. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [Article]
4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
5. Osborne SA, Tonissen KF: Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes. BMC Genomics. 2001;2:10. doi: 10.1186/1471-2164-2-10. Epub 2001 Nov 22. [Article]
6. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12. [Article]
7. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]
8. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details