CAI-1 autoinducer synthase
Details
- Name
- CAI-1 autoinducer synthase
- Synonyms
- 2.3.-.-
- Cholerae quorum-sensing autoinducer
- Gene Name
- cqsA
- Organism
- Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
- Amino acid sequence
>lcl|BSEQ0017397|CAI-1 autoinducer synthase MNKPQLPDFIQNKIDHYIENYFDINKNGKHLVLGKQASPDDIILQSNDYLALANHPLIKA RLAKSLLEEQQSLFMSASFLQNDYDKPMIEKRLAKFTGFDECLLSQSGWNANVGLLQTIC QPNTNVYIDFFAHMSLWEGARYANAQAHPFMHNNCDHLRMLIQRHGPGIIVVDSIYSTLG TIAPLAELVNISKEFGCALLVDESHSLGTHGPNGAGLLAELGLTREVHFMTASLAKTFAY RAGAIWCNNEVNRCVPFISYPAIFSSTLLPYEAAGLETTLEIIESADNRRQHLDRMARKL RIGLSQLGLTIRSESQIIGLETGDERNTEKVRDYLESNGVFGSVFCRPATSKNKNIIRLS LNSDVNDEQIAKIIEVCSDAVNYGDFYFR
- Number of residues
- 389
- Molecular Weight
- 43593.15
- Theoretical pI
- 6.23
- GO Classification
- Functionspyridoxal phosphate binding / transaminase activity / transferase activity, transferring acyl groupsProcessesbiosynthetic process
- General Function
- Transferase activity, transferring acyl groups
- Specific Function
- Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal.
- Pfam Domain Function
- Aminotran_1_2 (PF00155)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017398|CAI-1 autoinducer synthase (cqsA) ATGAACAAGCCTCAACTTCCTGATTTTATTCAGAACAAGATAGATCACTATATTGAAAAT TATTTTGATATAAACAAAAACGGTAAACACCTTGTATTGGGTAAACAAGCCAGCCCTGAT GACATTATTTTGCAAAGTAATGATTATCTCGCATTGGCCAATCATCCGTTGATCAAAGCT CGTTTGGCGAAGTCATTACTGGAAGAACAACAAAGCTTATTTATGTCAGCCTCATTTCTA CAAAATGACTATGACAAACCCATGATTGAGAAACGTCTGGCTAAGTTCACAGGCTTTGAT GAATGTCTATTATCTCAATCTGGTTGGAATGCAAACGTCGGTTTATTACAAACCATCTGC CAGCCCAATACGAATGTTTACATTGATTTTTTCGCGCACATGTCGTTATGGGAAGGGGCG CGCTACGCCAATGCTCAGGCGCATCCTTTTATGCATAATAACTGTGACCATTTACGTATG CTGATTCAACGTCATGGTCCTGGGATCATTGTCGTAGACTCGATTTACAGCACTTTAGGT ACGATTGCACCGCTAGCGGAACTGGTCAATATCAGTAAAGAGTTTGGCTGCGCCTTATTA GTCGATGAATCCCACTCTTTGGGCACACATGGCCCTAATGGTGCAGGTTTATTGGCAGAA TTAGGCCTCACTCGTGAAGTGCATTTTATGACCGCAAGTTTGGCCAAAACCTTTGCTTAT CGCGCAGGAGCCATTTGGTGTAACAATGAAGTGAATCGCTGCGTTCCTTTTATTAGTTAT CCAGCTATTTTTAGTTCTACTTTGCTGCCTTATGAAGCGGCAGGATTAGAAACGACTTTA GAGATTATTGAATCTGCGGATAATCGTCGTCAGCATTTAGATCGTATGGCAAGAAAATTA CGCATAGGATTATCCCAGCTGGGATTAACCATTCGCAGTGAAAGCCAAATTATTGGTCTA GAAACAGGAGATGAACGAAATACCGAAAAAGTTCGGGATTATTTAGAAAGTAATGGAGTG TTTGGCTCAGTATTCTGCCGCCCGGCAACTTCAAAGAATAAAAACATTATTCGCTTATCA CTCAATAGTGATGTGAACGATGAGCAAATCGCCAAAATAATTGAGGTTTGCTCTGATGCG GTCAACTACGGTGATTTTTATTTTCGTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9KM65 UniProtKB Entry Name CQSA_VIBCH GenBank Protein ID 9657379 GenBank Gene ID AE003853 - General References
- Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM: DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature. 2000 Aug 3;406(6795):477-83. [Article]
- Miller MB, Skorupski K, Lenz DH, Taylor RK, Bassler BL: Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae. Cell. 2002 Aug 9;110(3):303-14. [Article]
- Higgins DA, Pomianek ME, Kraml CM, Taylor RK, Semmelhack MF, Bassler BL: The major Vibrio cholerae autoinducer and its role in virulence factor production. Nature. 2007 Dec 6;450(7171):883-6. Epub 2007 Nov 14. [Article]