Beta-lactamase

Details

Name
Beta-lactamase
Synonyms
  • 3.5.2.6
  • blaCTX-M-9
  • blaCTX-M-9b
Gene Name
blaCTX-M-9a
Organism
Escherichia coli
Amino acid sequence
>lcl|BSEQ0022432|Beta-lactamase
MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSGGRLGVALIDTADNTQ
VLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTM
TLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDP
RDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTAGDKTGS
GDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL
Number of residues
291
Molecular Weight
30951.03
Theoretical pI
9.38
GO Classification
Functions
beta-lactamase activity
Processes
beta-lactam antibiotic catabolic process / response to antibiotic
General Function
Beta-lactamase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0005330|876 bp
ATGGTGACAAAGAGAGTGCAACGGATGATGTTCGCGGCGGCGGCGTGCATTCCGCTGCTG
CTGGGCAGCGCGCCGCTTTATGCGCAGACGAGTGCGGTGCAGCAAAAGCTGGCGGCGCTG
GAGAAAAGCAGCGGAGGGCGGCTGGGCGTCGCGCTCATCGATACCGCAGATAATACGCAG
GTGCTTTATCGCGGTGATGAACGCTTTCCAATGTGCAGTACCAGTAAAGTTATGGCGGCC
GCGGCGGTGCTTAAGCAGAGTGAAACGCAAAAGCAGCTGCTTAATCAGCCTGTCGAGATC
AAGCCTGCCGATCTGGTTAACTACAATCCGATTGCCGAAAAACACGTCAACGGCACAATG
ACGCTGGCAGAGCTGAGCGCGGCCGCGTTGCAGTACAGCGACAATACCGCCATGAACAAA
TTGATTGCCCAGCTCGGTGGCCCGGGAGGCGTGACGGCTTTTGCCCGCGCGATCGGCGAT
GAGACGTTTCGTCTGGATCGCACTGAACCTACGCTGAATACCGCCATTCCCGGCGACCCG
AGAGACACCACCACGCCGCGGGCGATGGCACAGACGTTGCGTCAGCTTACGCTGGGTCAT
GCGCTGGGCGAAACCCAGCGGGCGCAGTTGGTGACGTGGCTCAAAGGCAATACGACCGGC
GCAGCCAGCATTCGGGCCGGCTTACCGACGTCGTGGACTGCAGGTGATAAGACCGGCAGC
GGCGACTACGGCACCACCAATGATATTGCGGTGATCTGGCCGCAGGGTCGTGCGCCGCTG
GTTCTGGTGACCTATTTTACCCAGCCGCAACAGAACGCAGAGAGCCGCCGCGATGTGCTG
GCTTCAGCGGCGAGAATCATCGCCGAAGGGCTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9L5C8
UniProtKB Entry NameQ9L5C8_ECOLX
GenBank Gene IDAF252621
General References
  1. Chen Y, Shoichet B, Bonnet R: Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases. J Am Chem Soc. 2005 Apr 20;127(15):5423-34. [Article]
  2. Chen Y, Delmas J, Sirot J, Shoichet B, Bonnet R: Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability. J Mol Biol. 2005 Apr 29;348(2):349-62. [Article]
  3. Chen Y, Bonnet R, Shoichet BK: The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution. J Am Chem Soc. 2007 May 2;129(17):5378-80. Epub 2007 Apr 5. [Article]
  4. Chen Y, Shoichet BK: Molecular docking and ligand specificity in fragment-based inhibitor discovery. Nat Chem Biol. 2009 May;5(5):358-64. doi: 10.1038/nchembio.155. Epub 2009 Mar 22. [Article]
  5. Delmas J, Leyssene D, Dubois D, Birck C, Vazeille E, Robin F, Bonnet R: Structural insights into substrate recognition and product expulsion in CTX-M enzymes. J Mol Biol. 2010 Jul 2;400(1):108-20. doi: 10.1016/j.jmb.2010.04.062. Epub 2010 May 7. [Article]
  6. Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y: Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A beta-lactamase. J Med Chem. 2012 Mar 8;55(5):2163-72. doi: 10.1021/jm2014138. Epub 2012 Feb 14. [Article]
  7. Tondi D, Venturelli A, Bonnet R, Pozzi C, Shoichet BK, Costi MP: Targeting class A and C serine beta-lactamases with a broad-spectrum boronic acid derivative. J Med Chem. 2014 Jun 26;57(12):5449-58. doi: 10.1021/jm5006572. Epub 2014 Jun 16. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02772Sucroseapproved, experimental, investigationalunknownDetails
DB02841[(2-Ethoxy-1-Naphthoyl)Amino]Methylboronic AcidexperimentalunknownDetails
DB068893-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-oneexperimentalunknownDetails
DB070552-[2-(1H-tetrazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dioneexperimentalunknownDetails
DB077293-fluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzamideexperimentalunknownDetails
DB07808(1S,2R)-2-[(2,5-difluorophenyl)carbamoyl]cyclopropanecarboxylic acidexperimentalunknownDetails
DB07823(2S)-2-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]propanoic acidexperimentalunknownDetails
DB078244-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-oneexperimentalunknownDetails
DB078653-(1H-tetrazol-5-ylamino)cyclohex-2-en-1-oneexperimentalunknownDetails
DB085513-{(R)-(Dihydroxyboryl)[(2-thienylacetyl)amino]methyl}benzoic acidexperimentalunknownDetails