Zinc transporter ZIP2
Details
- Name
- Zinc transporter ZIP2
- Synonyms
- 6A1
- Eti-1
- hZIP2
- Solute carrier family 39 member 2
- ZIP-2
- ZIP2
- Zrt- and Irt-like protein 2
- Gene Name
- SLC39A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052341|Zinc transporter ZIP2 MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLVLRLLGCISAGVFLGAG FMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEYPYGELIISLGFFFVFFLE SLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSKGPLRALVLLLSLSFHSVFEG LAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAVFSILLLALMSPLGLA VGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLEILPRELASPEAPLAKWSCVAAGFA FMAFIALWA
- Number of residues
- 309
- Molecular Weight
- 32742.03
- Theoretical pI
- Not Available
- GO Classification
- Functionszinc ion transmembrane transporter activityProcesseszinc ion transmembrane transport / zinc ion transportComponentscytoplasmic ribonucleoprotein granule / cytoplasmic vesicle / integral component of plasma membrane / membrane / plasma membrane
- General Function
- Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
- Specific Function
- Zinc ion transmembrane transporter activity
- Pfam Domain Function
- Zip (PF02535)
- Transmembrane Regions
- 9-29 47-67 104-124 165-185 190-210 225-245 259-279 289-309
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052342|Zinc transporter ZIP2 (SLC39A2) ATGGAGCAACTACTAGGAATAAAACTTGGCTGCCTGTTTGCCCTGTTGGCTCTCACTCTG GGCTGTGGCCTTACTCCCATCTGCTTCAAATGGTTCCAGATTGATGCAGCCAGAGGTCAT CACCGGCTAGTCCTCAGACTCCTGGGCTGTATTTCTGCTGGTGTTTTCCTGGGAGCAGGG TTCATGCATATGACTGCTGAAGCCCTGGAGGAAATTGAATCACAGATTCAGAAGTTCATG GTGCAGAACAGATCAGCAAGTGAGAGAAATTCTTCTGGTGATGCTGATTCAGCTCATATG GAGTATCCCTATGGAGAGCTCATCATCTCCCTGGGCTTCTTTTTTGTCTTCTTTTTGGAG TCGCTGGCATTGCAGTGCTGTCCTGGGGCTGCTGGAGGATCGACAGTGCAGGACGAAGAA TGGGGTGGGGCTCATATCTTCGAACTCCACAGCCATGGACATTTACCCTCACCCTCAAAG GGTCCCCTCCGAGCCCTTGTCCTCTTGCTGTCACTCTCCTTTCACTCAGTGTTTGAAGGG CTAGCTGTGGGGCTGCAGCCGACAGTAGCAGCTACCGTGCAGCTCTGCCTTGCTGTCCTG GCTCATAAGGGGCTTGTGGTGTTTGGTGTAGGAATGCGGCTAGTGCATTTAGGTACCAGC TCACGATGGGCAGTGTTCTCCATACTATTATTAGCTCTCATGTCCCCCCTGGGCCTAGCC GTAGGGCTGGCTGTGACTGGAGGGGACTCTGAAGGAGGGCGGGGCTTAGCCCAGGCTGTG TTAGAGGGTGTGGCAGCTGGTACCTTCCTGTATGTCACCTTCCTAGAAATTCTTCCACGG GAGCTAGCTAGTCCTGAGGCCCCTCTAGCTAAGTGGAGCTGTGTAGCCGCTGGTTTTGCC TTCATGGCCTTTATTGCCTTGTGGGCCTGA
- Chromosome Location
- 14
- Locus
- 14q11.2
- External Identifiers
Resource Link UniProtKB ID Q9NP94 UniProtKB Entry Name S39A2_HUMAN HGNC ID HGNC:17127 - General References
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