Triggering receptor expressed on myeloid cells 1
Details
- Name
- Triggering receptor expressed on myeloid cells 1
- Synonyms
- TREM-1
- Triggering receptor expressed on monocytes 1
- Gene Name
- TREM1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002562|Triggering receptor expressed on myeloid cells 1 MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRD GEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKST ADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP
- Number of residues
- 234
- Molecular Weight
- 26386.385
- Theoretical pI
- 9.13
- GO Classification
- Functionsreceptor activity / scaffold protein bindingProcessesblood coagulation / chemokine metabolic process / cytokine secretion involved in immune response / humoral immune response / innate immune response / intracellular signal transduction / leukocyte migration / mitophagy in response to mitochondrial depolarization / neutrophil chemotaxis / neutrophil extravasation / neutrophil mediated killing of gram-negative bacterium / positive regulation of defense response to virus by host / regulation of immune response / xenophagyComponentsextracellular region / integral component of membrane / intracellular / plasma membrane
- General Function
- Scaffold protein binding
- Specific Function
- Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
- Pfam Domain Function
- V-set (PF07686)
- Transmembrane Regions
- 206-226
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016375|Triggering receptor expressed on myeloid cells 1 (TREM1) ATGAGGAAGACCAGGCTCTGGGGGCTGCTGTGGATGCTCTTTGTCTCAGAACTCCGAGCT GCAACTAAATTAACTGAGGAAAAGTATGAACTGAAAGAGGGGCAGACCCTGGATGTGAAA TGTGACTACACGCTAGAGAAGTTTGCCAGCAGCCAGAAAGCTTGGCAGATAATAAGGGAC GGAGAGATGCCCAAGACCCTGGCATGCACAGAGAGGCCTTCAAAGAATTCCCATCCAGTC CAAGTGGGGAGGATCATACTAGAAGACTACCATGATCATGGTTTACTGCGCGTCCGAATG GTCAACCTTCAAGTGGAAGATTCTGGACTGTATCAGTGTGTGATCTACCAGCCTCCCAAG GAGCCTCACATGCTGTTCGATCGCATCCGCTTGGTGGTGACCAAGGGTTTTTCAGGGACC CCTGGCTCCAATGAGAATTCTACCCAGAATGTGTATAAGATTCCTCCTACCACCACTAAG GCCTTGTGCCCACTCTATACCAGCCCCAGAACTGTGACCCAAGCTCCACCCAAGTCAACT GCCGATGTCTCCACTCCTGACTCTGAAATCAACCTTACAAATGTGACAGATATCATCAGG TATAGTTTCCAGGTCCCTGGGCCCCTGGTTTGGACACTGAGCCCTTTGTTTCCCAGTCTG TGTGCTGAGAGGATGTGA
- Chromosome Location
- 6
- Locus
- 6p21.1
- External Identifiers
Resource Link UniProtKB ID Q9NP99 UniProtKB Entry Name TREM1_HUMAN GenBank Protein ID 8050527 GenBank Gene ID AF196329 GenAtlas ID TREM1 HGNC ID HGNC:17760 - General References
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