Transient receptor potential cation channel subfamily V member 5
Details
- Name
- Transient receptor potential cation channel subfamily V member 5
- Synonyms
- Calcium transport protein 2
- CaT2
- ECaC
- ECAC1
- Epithelial calcium channel 1
- Osm-9-like TRP channel 3
- OTRPC3
- TrpV5
- Gene Name
- TRPV5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008876|Transient receptor potential cation channel subfamily V member 5 MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE GDGEEVYHF
- Number of residues
- 729
- Molecular Weight
- 82549.89
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium channel activityProcessescalcium ion transmembrane transport / calcium ion transport / ion transmembrane transport / protein tetramerization / transmembrane transportComponentsapical plasma membrane / integral component of plasma membrane / plasma membrane
- General Function
- Calcium channel activity
- Specific Function
- Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- 328-348 388-408 420-440 449-469 493-513 557-577
- Cellular Location
- Apical cell membrane
- Gene sequence
>lcl|BSEQ0020839|Transient receptor potential cation channel subfamily V member 5 (TRPV5) ATGGGGGGTTTTCTACCTAAGGCAGAAGGGCCCGGGAGCCAACTCCAGAAACTTCTGCCC TCCTTTCTGGTCAGAGAACAAGACTGGGACCAGCACCTGGACAAGCTTCATATGCTGCAG CAGAAGAGGATTCTAGAGTCTCCACTGCTTCGAGCATCCAAGGAAAATGACCTGTCTGTT CTTAGGCAACTTCTACTGGACTGCACCTGTGACGTTCGACAAAGAGGAGCCCTGGGGGAG ACGGCGCTGCACATAGCAGCCCTCTATGACAACTTGGAGGCGGCCTTGGTGCTGATGGAG GCTGCCCCAGAGCTGGTCTTTGAGCCCACCACATGTGAGGCTTTTGCAGGTCAGACTGCA CTGCACATCGCTGTTGTGAACCAGAATGTGAACCTGGTGCGTGCCCTGCTCACCCGCAGG GCCAGTGTCTCTGCCAGAGCCACAGGCACTGCCTTCCGCCATAGTCCCCGCAACCTCATC TACTTTGGGGAGCACCCTTTGTCCTTTGCTGCCTGTGTGAACAGCGAGGAGATCGTGCGG CTGCTCATTGAGCATGGAGCTGACATCAGGGCCCAGGACTCCCTGGGAAACACAGTATTA CACATCCTCATCCTCCAGCCCAACAAAACCTTTGCCTGCCAGATGTACAACCTGCTGCTG TCCTATGATGGACATGGGGACCACCTGCAGCCCCTGGACCTTGTGCCCAATCACCAGGGT CTCACCCCCTTCAAGCTGGCTGGAGTGGAGGGTAACACTGTGATGTTCCAGCACCTGATG CAGAAGCGGAGGCACATCCAGTGGACGTATGGACCCCTGACCTCCATTCTCTACGACCTC ACGGAGATCGACTCCTGGGGAGAGGAGCTGTCCTTCCTGGAGCTTGTGGTCTCCTCTGAT AAACGAGAGGCTCGCCAAATTCTGGAACAGACCCCAGTGAAGGAGCTGGTGAGCTTCAAG TGGAACAAGTATGGCCGGCCGTACTTCTGCATCCTGGCTGCCTTGTACCTGCTCTACATG ATCTGCTTTACTACGTGCTGCGTCTACCGCCCCCTTAAGTTTCGTGGTGGCAACCGCACT CATTCTCGAGACATCACCATCCTCCAGCAAAAACTACTACAGGAGGCCTATGAGACACGT GAAGATATCATCAGGCTGGTGGGGGAGCTGGTGAGCATCGTTGGGGCTGTGATCATCCTG CTCCTAGAGATTCCAGACATCTTCAGGGTTGGTGCCTCTCGCTATTTTGGAAAGACGATT CTTGGGGGGCCATTCCATGTCATCATCATCACCTATGCCTCCCTGGTGCTGGTGACCATG GTGATGCGGCTCACCAACACCAATGGGGAGGTGGTGCCCATGTCCTTTGCCCTGGTGCTG GGCTGGTGCAGTGTCATGTATTTCACTCGAGGATTCCAGATGCTGGGTCCCTTCACCATC ATGATCCAGAAGATGATTTTTGGAGACCTAATGCGTTTCTGCTGGCTGATGGCTGTGGTC ATCTTGGGATTTGCCTCCGCGTTCTATATCATTTTCCAGACAGAGGACCCAACCAGTCTG GGGCAATTCTATGACTACCCCATGGCACTGTTCACCACCTTTGAGCTTTTTCTCACTGTT ATTGATGCACCTGCCAACTACGACGTGGACTTGCCCTTCATGTTCAGCATTGTCAACTTC GCCTTCACCATCATTGCCACACTGCTCATGCTCAACTTGTTCATCGCCATGATGGGCGAC ACCCACTGGAGGGTGGCCCAGGAGAGGGATGAGCTCTGGAGGGCCCAGGTCGTGGCCACC ACAGTGATGCTGGAGCGGAAGCTGCCTCGCTGCCTGTGGCCTCGCTCCGGGATCTGTGGG TGCGAATTCGGGCTGGGGGACCGCTGGTTCCTGCGGGTTGAGAACCACAATGATCAGAAT CCTCTGCGAGTGCTTCGCTATGTGGAAGTGTTCAAGAACTCAGACAAGGAGGATGACCAG GAGCATCCATCTGAGAAACAGCCCTCTGGGGCTGAGAGTGGGACTCTAGCCAGAGCCTCT TTGGCTCTTCCAACTTCCTCCCTGTCCCGGACCGCGTCCCAGAGCAGCAGTCACCGAGGC TGGGAGATCCTTCGTCAAAACACCCTGGGGCACTTGAATCTTGGACTGAACCTTAGTGAG GGGGATGGAGAGGAGGTCTACCATTTTTGA
- Chromosome Location
- 7
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9NQA5 UniProtKB Entry Name TRPV5_HUMAN HGNC ID HGNC:3145 - General References
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