Sodium- and chloride-dependent GABA transporter 2
Details
- Name
- Sodium- and chloride-dependent GABA transporter 2
- Synonyms
- GAT-2
- GAT2
- Solute carrier family 6 member 13
- Gene Name
- SLC6A13
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008625|Sodium- and chloride-dependent GABA transporter 2 MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES HC
- Number of residues
- 602
- Molecular Weight
- 68008.205
- Theoretical pI
- Not Available
- GO Classification
- Functionsgamma-aminobutyric acid / neurotransmitterProcessesgamma-aminobutyric acid transport / neurotransmitter secretion / neurotransmitter transport / synaptic transmission / transmembrane transportComponentsextracellular exosome / integral component of plasma membrane / neuron projection / plasma membrane
- General Function
- Neurotransmitter:sodium symporter activity
- Specific Function
- Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport.
- Pfam Domain Function
- SNF (PF00209)
- Transmembrane Regions
- 41-61 68-88 121-141 207-227 233-253 282-302 319-339 366-386 418-438 453-473 490-510 528-548
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019636|Sodium- and chloride-dependent GABA transporter 2 (SLC6A13) ATGGATAGCAGGGTCTCAGGCACAACCAGTAATGGAGAGACAAAACCAGTGTATCCAGTC ATGGAAAAGAAGGAGGAAGATGGCACCCTGGAGCGGGGGCACTGGAACAACAAGATGGAG TTTGTGCTGTCAGTGGCTGGGGAGATCATTGGCTTAGGCAACGTCTGGAGGTTTCCCTAT CTCTGCTACAAAAATGGGGGAGAACACTGTATGGAGTTCCAGAAGACCAACGGCTCCCTG AATGGTACCTCTGAGAATGCCACCTCTCCTGTCATCGAGTTCTGGGAGCGGCGGGTCTTG AAGATCTCTGATGGGATCCAGCACCTGGGGGCCCTGCGCTGGGAGCTGGCTCTGTGCCTC CTGCTGGCCTGGGTCATCTGCTACTTCTGCATCTGGAAGGGGGTGAAGTCCACAGGCAAG GTGGTGTACTTCACGGCCACATTTCCTTACCTCATGCTGGTGGTCCTGTTAATTCGAGGG GTGACGTTGCCTGGGGCAGCCCAAGGAATTCAGTTTTACCTGTACCCAAACCTCACGCGT CTGTGGGATCCCCAGGTGTGGATGGATGCAGGCACCCAGATATTCTTCTCCTTCGCCATC TGTCTTGGGTGCCTGACAGCCCTGGGCAGCTACAACAAGTACCACAACAACTGCTACAGG GACTGCATCGCCCTCTGCTTCCTCAACAGCGGCACCAGCTTTGTGGCCGGCTTTGCCATC TTCTCCATCCTGGGCTTCATGTCTCAGGAGCAGGGGGTGCCCATTTCTGAGGTGGCCGAG TCAGGCCCTGGCCTGGCTTTCATCGCTTACCCGCGGGCTGTGGTGATGCTGCCCTTCTCT CCTCTCTGGGCCTGCTGTTTCTTCTTCATGGTCGTTCTCCTGGGACTGGATAGCCAGTTT GTGTGTGTAGAAAGCCTGGTGACAGCGCTGGTGGACATGTACCCTCACGTGTTCCGCAAG AAGAACCGGAGGGAAGTCCTCATCCTTGGAGTATCTGTCGTCTCCTTCCTTGTGGGGCTG ATCATGCTCACAGAGGGCGGAATGTACGTGTTCCAGCTCTTTGACTACTATGCGGCCAGT GGCATGTGCCTCCTGTTCGTGGCCATCTTCGAGTCCCTCTGTGTGGCTTGGGTTTACGGA GCCAAGCGCTTCTACGACAACATCGAAGACATGATTGGGTACAGGCCATGGCCTCTTATC AAATACTGTTGGCTCTTCCTCACACCAGCTGTGTGCACAGCCACCTTTCTCTTCTCCCTG ATAAAGTACACTCCGCTGACCTACAACAAGAAGTACACGTACCCGTGGTGGGGCGATGCC CTGGGCTGGCTCCTGGCTCTGTCCTCCATGGTCTGCATTCCTGCCTGGAGCCTCTACAGA CTCGGAACCCTCAAGGGCCCCTTCAGAGAGAGAATCCGTCAGCTCATGTGCCCAGCCGAG GACCTGCCCCAGCGGAACCCAGCAGGACCCTCGGCTCCCGCCACCCCCAGGACCTCACTG CTCAGACTCACAGAGCTAGAGTCTCACTGCTAG
- Chromosome Location
- 12
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9NSD5 UniProtKB Entry Name S6A13_HUMAN HGNC ID HGNC:11046 - General References
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