Uridine-cytidine kinase-like 1

Details

Name
Uridine-cytidine kinase-like 1
Synonyms
  • 2.7.1.48
  • URKL1
Gene Name
UCKL1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009503|Uridine-cytidine kinase-like 1
MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDRSNAESLDRLLPPVGTGRSPRKR
TTSQCKSEPPLLRTSKRTIYTAGRPPWYNEHGTQSKEAFAIGLGGGSASGKTTVARMIIE
ALDVPWVVLLSMDSFYKVLTEQQQEQAAHNNFNFDHPDAFDFDLIISTLKKLKQGKSVKV
PIYDFTTHSRKKDWKTLYGANVIIFEGIMAFADKTLLELLDMKIFVDTDSDIRLVRRLRR
DISERGRDIEGVIKQYNKFVKPSFDQYIQPTMRLADIVVPRGSGNTVAIDLIVQHVHSQL
EERELSVRAALASAHQCHPLPRTLSVLKSTPQVRGMHTIIRDKETSRDEFIFYSKRLMRL
LIEHALSFLPFQDCVVQTPQGQDYAGKCYAGKQITGVSILRAGETMEPALRAVCKDVRIG
TILIQTNQLTGEPELHYLRLPKDISDDHVILMDCTVSTGAAAMMAVRVLLDHDVPEDKIF
LLSLLMAEMGVHSVAYAFPRVRIITTAVDKRVNDLFRIIPGIGNFGDRYFGTDAVPDGSD
EEEVAYTG
Number of residues
548
Molecular Weight
61140.395
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / uridine kinase activity
Processes
CTP salvage / pyrimidine nucleobase metabolic process / pyrimidine nucleoside salvage / UMP salvage / viral process
Components
cytosol / nucleus
General Function
Uridine kinase activity
Specific Function
May contribute to UTP accumulation needed for blast transformation and proliferation.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0013201|Uridine-cytidine kinase-like 1 (UCKL1)
ATGAGCAGCCCCCCAGCTTACCCTGGCATCAGGATCTCAGGGTGCCGGGCCCTTGGAGCA
GAAGGCAGCAGCAATGCAGAGTCCCTGGACAGGCTCCTGCCACCTGTGGGCACTGGGCGC
TCTCCCCGGAAGCGGACCACCAGCCAGTGCAAGTCAGAGCCTCCCCTGCTGCGTACAAGC
AAGCGTACCATCTACACCGCCGGGCGGCCGCCCTGGTACAATGAACACGGCACGCAATCC
AAAGAGGCCTTCGCCATCGGCTTGGGAGGCGGCAGTGCCTCTGGGAAGACCACTGTGGCC
AGAATGATCATCGAGGCCCTGGATGTGCCCTGGGTGGTCTTGCTGTCCATGGACTCCTTC
TACAAGGTGCTGACTGAGCAGCAGCAGGAACAGGCCGCACACAACAACTTCAACTTCGAC
CACCCAGATGCCTTTGACTTCGACCTCATCATTTCCACCCTCAAGAAGCTGAAGCAGGGG
AAGAGTGTCAAGGTGCCCATTTATGACTTCACCACGCACAGCCGGAAGAAGGACTGGAAA
ACACTGTATGGTGCAAACGTCATCATCTTTGAGGGCATCATGGCCTTTGCTGACAAGACA
CTGTTGGAGCTCCTGGACATGAAGATCTTTGTGGACACAGACTCCGACATCCGCCTGGTA
CGGCGGCTGCGCCGGGACATCAGTGAGCGCGGCCGGGACATCGAGGGTGTCATCAAGCAG
TACAACAAGTTTGTCAAGCCCTCCTTCGACCAGTACATCCAGCCCACCATGCGCCTGGCA
GACATCGTGGTCCCCAGAGGGAGCGGCAACACGGTGGCCATCGACCTGATTGTGCAGCAC
GTGCACAGCCAGCTGGAGGAGCGTGAACTCAGCGTCAGGGCTGCGCTGGCCTCGGCACAC
CAGTGCCACCCGCTGCCCCGGACGCTGAGCGTCCTGAAGAGCACGCCGCAGGTACGGGGC
ATGCACACCATCATCAGGGACAAGGAGACCAGTCGCGACGAGTTCATCTTCTACTCCAAG
AGACTGATGCGGCTGCTCATCGAGCACGCGCTCTCCTTCCTGCCCTTTCAGGACTGCGTC
GTACAGACCCCGCAGGGGCAGGACTATGCGGGCAAGTGCTATGCGGGGAAGCAGATCACC
GGTGTGTCCATTCTGCGCGCCGGTGAAACCATGGAGCCCGCGCTGCGCGCTGTGTGCAAA
GACGTGCGCATCGGCACCATCCTCATCCAGACCAACCAGCTTACCGGGGAGCCCGAGCTC
CACTACCTGAGGCTGCCCAAGGACATCAGCGATGACCACGTGATCCTCATGGACTGCACC
GTGTCCACGGGCGCGGCGGCCATGATGGCAGTGCGCGTGCTCCTGGACCACGACGTGCCT
GAGGACAAGATCTTTTTGCTGTCGCTGCTCATGGCAGAGATGGGCGTGCACTCAGTGGCC
TATGCATTTCCGCGAGTGAGAATCATCACCACGGCGGTGGACAAGCGGGTCAATGACCTT
TTCCGCATCATCCCAGGCATTGGGAACTTTGGCGACCGCTACTTTGGGACAGACGCGGTC
CCCGATGGCAGTGACGAGGAGGAAGTGGCCTACACGGGTTAG
Chromosome Location
20
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9NWZ5
UniProtKB Entry NameUCKL1_HUMAN
HGNC IDHGNC:15938
General References
  1. Kashuba E, Kashuba V, Sandalova T, Klein G, Szekely L: Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. BMC Cell Biol. 2002 Aug 29;3:23. Epub 2002 Aug 29. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Fortier JM, Kornbluth J: NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. J Immunol. 2006 Jun 1;176(11):6454-63. [Article]
  6. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. [Article]
  7. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
  8. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
  9. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  10. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB016325-O-phosphono-alpha-D-ribofuranosyl diphosphateapproved, experimental, investigationalunknownDetails
DB03419Uracilexperimental, investigationalunknownDetails
DB03685Uridine monophosphateexperimentalunknownDetails
DB04137Guanosine-5'-TriphosphateexperimentalunknownDetails