Elongation of very long chain fatty acids protein 2

Details

Name
Elongation of very long chain fatty acids protein 2
Synonyms
  • 2.3.1.199
  • 3-keto acyl-CoA synthase ELOVL2
  • ELG3
  • ELOVL FA elongase 2
  • ELOVL fatty acid elongase 2
  • SSC2
  • Very long chain 3-ketoacyl-CoA synthase 2
  • Very long chain 3-oxoacyl-CoA synthase 2
Gene Name
ELOVL2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052417|Elongation of very long chain fatty acids protein 2
MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRP
ALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYY
FSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIH
ILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSS
YMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ
Number of residues
296
Molecular Weight
34584.435
Theoretical pI
Not Available
GO Classification
Functions
3-oxo-arachidoyl-CoA synthase activity / 3-oxo-cerotoyl-CoA synthase activity / 3-oxo-lignoceronyl-CoA synthase activity / fatty acid elongase activity / very-long-chain 3-ketoacyl-CoA synthase activity
Processes
alpha-linolenic acid metabolic process / fatty acid elongation, monounsaturated fatty acid / fatty acid elongation, polyunsaturated fatty acid / fatty acid elongation, saturated fatty acid / linoleic acid metabolic process / long-chain fatty-acyl-CoA biosynthetic process / sphingolipid biosynthetic process / unsaturated fatty acid biosynthetic process / very long-chain fatty acid biosynthetic process
Components
endoplasmic reticulum / endoplasmic reticulum membrane / integral component of endoplasmic reticulum membrane
General Function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Specific Function
3-oxo-arachidoyl-coa synthase activity
Pfam Domain Function
Transmembrane Regions
29-49 67-87 115-135 153-173 175-195 208-225 230-250
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0052418|Elongation of very long chain fatty acids protein 2 (ELOVL2)
ATGGAACATCTAAAGGCCTTTGATGATGAAATCAATGCTTTTTTGGACAATATGTTTGGA
CCGCGAGATTCTCGAGTCAGAGGGTGGTTCATGTTGGACTCTTACCTTCCTACCTTTTTT
CTTACTGTCATGTATCTGCTCTCAATATGGCTGGGTAACAAGTATATGAAGAACAGACCT
GCTCTTTCTCTCAGGGGTATCCTCACCTTGTATAATCTTGGAATCACACTTCTCTCCGCG
TACATGCTGGCAGAGCTCATTCTCTCCACTTGGGAAGGAGGCTACAACTTACAGTGTCAA
GATCTTACCAGCGCAGGGGAAGCTGACATCCGGGTAGCCAAGGTGCTTTGGTGGTACTAT
TTCTCCAAATCAGTAGAGTTCCTGGACACAATTTTCTTCGTTTTGCGGAAAAAAACGAGT
CAGATTACTTTTCTTCATGTATATCATCATGCTTCTATGTTTAACATCTGGTGGTGTGTC
TTGAACTGGATACCTTGTGGACAAAGTTTCTTTGGACCAACACTGAACAGTTTTATCCAC
ATTCTTATGTACTCCTACTATGGACTTTCTGTGTTTCCATCTATGCACAAGTATCTTTGG
TGGAAGAAATATCTCACACAGGCTCAGCTGGTGCAGTTCGTGCTCACCATCACGCACACC
ATGAGCGCCGTCGTGAAACCGTGTGGCTTCCCCTTCGGTTGTCTCATCTTCCAGTCATCT
TATATGCTAACGTTAGTCATCCTCTTCTTAAATTTTTACGTTCAGACATACCGAAAAAAG
CCAATGAAGAAAGATATGCAAGAGCCACCTGCAGGGAAAGAAGTGAAGAATGGTTTTTCC
AAAGCCTACTTCACTGCAGCAAATGGAGTGATGAACAAGAAAGCACAATAA
Chromosome Location
6
Locus
6p24.2
External Identifiers
ResourceLink
UniProtKB IDQ9NXB9
UniProtKB Entry NameELOV2_HUMAN
HGNC IDHGNC:14416
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  4. de Antueno RJ, Knickle LC, Smith H, Elliot ML, Allen SJ, Nwaka S, Winther MD: Activity of human Delta5 and Delta6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids. FEBS Lett. 2001 Nov 30;509(1):77-80. doi: 10.1016/s0014-5793(01)03135-0. [Article]
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  6. Kitazawa H, Miyamoto Y, Shimamura K, Nagumo A, Tokita S: Development of a high-density assay for long-chain fatty acyl-CoA elongases. Lipids. 2009 Aug;44(8):765-73. doi: 10.1007/s11745-009-3320-8. Epub 2009 Jul 4. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00132alpha-Linolenic acidapproved, investigational, nutraceuticalunknownsubstrateDetails