Hydroxyacid oxidase 2
Details
- Name
- Hydroxyacid oxidase 2
- Synonyms
- (S)-2-hydroxy-acid oxidase, peroxisomal
- 1.1.3.15
- Cell growth-inhibiting gene 16 protein
- HAOX2
- Long chain alpha-hydroxy acid oxidase
- Long-chain L-2-hydroxy acid oxidase
- Gene Name
- HAO2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009498|Hydroxyacid oxidase 2 MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDT RTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAA PEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLT DLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQG IIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLG RPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL
- Number of residues
- 351
- Molecular Weight
- 38838.35
- Theoretical pI
- Not Available
- GO Classification
- Functions(S)-2-hydroxy-acid oxidase activity / FMN binding / long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity / medium-chain-(S)-2-hydroxy-acid oxidase activity / receptor binding / very-long-chain-(S)-2-hydroxy-acid oxidase activityProcessesfatty acid oxidationComponentsextracellular exosome / mitochondrion / peroxisome
- General Function
- Very-long-chain-(s)-2-hydroxy-acid oxidase activity
- Specific Function
- Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
- Pfam Domain Function
- FMN_dh (PF01070)
- Transmembrane Regions
- Not Available
- Cellular Location
- Peroxisome
- Gene sequence
>lcl|BSEQ0013199|Hydroxyacid oxidase 2 (HAO2) ATGGAAGACAAGATGTGGAGTGAATGTGAAGGTCCAGAAATGTCCTTGGTGTGTTTGACA GACTTTCAGGCCCATGCGCGAGAGCAGCTGTCTAAGTCAACTCGGGATTTTATTGAAGGT GGAGCAGATGACAGCATCACGCGGGATGACAACATTGCAGCATTTAAAAGAATTCGCCTC CGTCCGCGGTACCTGAGAGATGTGTCTGAGGTGGACACCAGAACCACAATCCAAGGGGAG GAGATCAGTGCCCCTATTTGTATCGCACCCACAGGGTTCCACTGCCTTGTCTGGCCTGAT GGGGAAATGAGCACAGCAAGAGCTGCCCAAGCGGCTGGTATCTGCTACATCACCAGCACA TTTGCCAGCTGTAGCCTTGAAGACATTGTCATTGCAGCTCCCGAAGGCCTCCGATGGTTC CAACTCTATGTGCATCCAGACCTGCAGCTGAACAAACAGTTGATCCAGAGGGTAGAATCC CTAGGTTTCAAAGCTTTGGTAATAACTTTGGATACACCTGTATGTGGCAACAGGCGACAT GACATTCGAAACCAGTTGAGGAGGAACTTAACACTAACAGATCTTCAATCACCTAAAAAG GGAAATGCAATACCTTATTTCCAGATGACTCCTATCAGCACTTCTCTCTGCTGGAATGAT CTCTCCTGGTTTCAGAGCATAACTCGATTGCCCATCATCCTGAAAGGGATTTTGACAAAA GAGGATGCAGAGTTAGCTGTGAAGCACAATGTCCAGGGTATCATTGTTTCCAACCATGGT GGGAGGCAGCTTGATGAGGTTCTTGCTTCAATTGATGCTTTGACAGAAGTGGTGGCTGCT GTAAAGGGGAAAATTGAAGTCTACCTGGATGGCGGGGTCCGAACTGGCAATGATGTGCTG AAGGCTCTGGCCCTTGGAGCTAAGTGCATTTTTCTTGGGAGACCAATCCTATGGGGCCTT GCCTGCAAGGGTGAACATGGTGTTAAGGAAGTTTTGAACATTTTAACAAATGAGTTCCAC ACTTCCATGGCCCTTACAGGCTGCCGGTCGGTCGCTGAGATCAATCGAAACTTGGTCCAG TTTTCCAGGCTGTAA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9NYQ3 UniProtKB Entry Name HAOX2_HUMAN HGNC ID HGNC:4810 - General References
- Jones JM, Morrell JC, Gould SJ: Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases. J Biol Chem. 2000 Apr 28;275(17):12590-7. [Article]
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