Polycystic kidney disease 2-like 1 protein
Details
- Name
- Polycystic kidney disease 2-like 1 protein
- Synonyms
- PKD2L
- PKDL
- Polycystin-2 homolog
- Polycystin-2L1
- Polycystin-L
- Polycystin-L1
- TRPP3
- Gene Name
- PKD2L1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049525|Polycystic kidney disease 2-like 1 protein MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQET AYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYG MTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSL GHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPF NGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRV VFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFC VFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQ QPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGF AVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAY FVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKE RVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEK MRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETV LEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEV PYKREEEALEERRLSRGEIPTLQRS
- Number of residues
- 805
- Molecular Weight
- 91981.23
- Theoretical pI
- Not Available
- GO Classification
- Functionsalpha-actinin binding / calcium activated cation channel activity / calcium channel activity / calcium ion binding / calcium-activated potassium channel activity / cation channel activity / cytoskeletal protein binding / identical protein binding / muscle alpha-actinin binding / sodium channel activity / sour taste receptor activityProcessescation transport / cellular response to acidic pH / detection of chemical stimulus involved in sensory perception of sour taste / detection of mechanical stimulus / potassium ion transmembrane transport / protein homotrimerization / sensory perception of sour taste / smoothened signaling pathway / sodium ion transmembrane transportComponentscalcium channel complex / cell surface / ciliary membrane / endoplasmic reticulum / integral component of membrane / intracellular membrane-bounded organelle / membrane / non-motile cilium / plasma membrane / receptor complex
- General Function
- Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
- Specific Function
- Alpha-actinin binding
- Pfam Domain Function
- PKD_channel (PF08016)
- Transmembrane Regions
- 104-124 314-334 348-368 385-405 477-497 540-560
- Cellular Location
- Cell projection
- Gene sequence
>lcl|BSEQ0049526|Polycystic kidney disease 2-like 1 protein (PKD2L1) ATGAATGCTGTGGGAAGTCCTGAGGGGCAGGAGCTGCAAAAGCTGGGGAGTGGAGCCTGG GACAACCCCGCCTACAGTGGTCCCCCTTCCCCACACGGGACGCTGAGAGTCTGCACCATC TCCAGCACGGGGCCTCTCCAGCCCCAACCCAAGAAGCCTGAAGATGAACCCCAGGAGACG GCATACAGGACCCAGGTGTCCAGCTGCTGCCTCCATATCTGTCAAGGCATCAGAGGACTT TGGGGAACAACCCTGACTGAGAACACAGCTGAGAACCGGGAACTTTATATCAAGACCACC CTGAGGGAGCTGTTGGTATATATTGTGTTCCTGGTGGACATCTGTCTACTGACCTATGGA ATGACAAGCTCCAGTGCTTATTACTACACCAAAGTGATGTCTGAGCTCTTCTTACATACT CCATCAGACACTGGAGTCTCCTTTCAGGCCATCAGCAGCATGGCGGACTTCTGGGATTTT GCCCAGGGCCCACTACTGGACAGTTTGTATTGGACCAAATGGTACAACAACCAGAGCCTG GGCCATGGCTCCCACTCCTTCATCTACTATGAGAACATGCTGCTGGGGGTTCCGAGGCTG CGGCAGCTAAAGGTCCGCAATGACTCCTGTGTGGTGCATGAAGACTTCCGGGAGGACATT CTGAGCTGCTATGATGTCTACTCTCCAGACAAAGAAGAACAACTCCCCTTTGGGCCCTTC AATGGCACAGCGTGGACATACCACTCGCAGGATGAGTTGGGGGGCTTCTCCCACTGGGGC AGGCTCACAAGCTACAGCGGAGGTGGCTACTACCTGGACCTTCCAGGATCCCGACAGGGT AGTGCAGAGGCTCTCCGGGCCCTTCAGGAGGGGCTGTGGCTGGACAGGGGCACTCGAGTG GTGTTCATCGACTTCTCAGTCTACAATGCCAATATCAATCTTTTCTGTGTCCTGAGGCTG GTGGTGGAGTTTCCAGCTACAGGAGGTGCCATCCCATCCTGGCAAATCCGCACAGTCAAG CTGATCCGCTATGTCAGCAACTGGGACTTCTTTATCGTTGGCTGTGAGGTCATCTTCTGC GTCTTCATCTTCTACTATGTGGTGGAAGAGATCCTGGAGCTCCACATTCACCGGCTTCGC TACCTCAGCAGCATCTGGAACATACTGGACCTGGTGGTCATCTTGCTCTCCATTGTGGCT GTGGGCTTCCACATATTCCGAACCCTCGAGGTGAATCGGCTCATGGGGAAGCTCCTGCAG CAGCCAAACACGTATGCAGACTTTGAGTTCCTCGCCTTCTGGCAGACACAGTACAACAAC ATGAATGCTGTCAACCTCTTCTTCGCCTGGATCAAGATATTCAAGTACATCAGCTTCAAC AAAACCATGACCCAGCTCTCCTCCACGCTGGCCCGCTGTGCCAAGGACATCCTGGGCTTC GCCGTCATGTTCTTCATTGTTTTCTTCGCCTATGCCCAACTCGGCTACCTGCTTTTCGGG ACCCAAGTGGAAAACTTTAGCACTTTCATCAAGTGCATTTTCACTCAGTTCCGGATAATC CTCGGGGACTTTGACTACAATGCTATCGACAATGCCAACCGCATCCTGGGCCCTGCCTAC TTTGTCACCTATGTCTTCTTCGTCTTCTTCGTGCTCCTGAACATGTTCCTGGCCATCATC AATGACACATATTCAGAGGTCAAGGAGGAGCTGGCTGGACAGAAGGATGAGCTGCAACTT TCTGACCTCCTGAAACAGGGCTACAACAAGACCCTACTAAGACTGCGTCTGAGGAAGGAG AGGGTTTCGGATGTGCAGAAGGTCCTGCAGGGTGGGGAGCAGGAGATCCAGTTTGAGGAT TTCACCAACACCTTAAGGGAACTGGGACACGCAGAGCATGAAATCACTGAGCTCACGGCC ACCTTCACCAAGTTTGACAGAGATGGGAATCGTATTCTGGATGAGAAGGAACAGGAAAAA ATGCGACAGGACCTGGAGGAAGAGAGGGTGGCCCTCAACACTGAGATTGAGAAACTAGGC CGATCTATTGTGAGCAGCCCACAAGGCAAATCGGGTCCAGAGGCTGCCAGAGCAGGAGGC TGGGTTTCAGGAGAAGAATTCTACATGCTCACAAGGAGAGTTCTGCAGCTGGAGACTGTC CTGGAAGGAGTAGTGTCCCAGATTGATGCTGTAGGCTCAAAGCTGAAAATGCTGGAGAGG AAGGGGTGGCTGGCTCCCTCCCCAGGCGTGAAGGAACAAGCTATTTGGAAGCACCCGCAG CCAGCCCCAGCTGTGACCCCAGACCCCTGGGGAGTCCAGGGTGGGCAGGAGAGTGAGGTT CCCTATAAAAGAGAAGAGGAAGCCTTAGAGGAGAGGAGACTCTCCCGTGGTGAGATTCCA ACGTTGCAGAGGAGTTAA
- Chromosome Location
- 10
- Locus
- 10q24.31
- External Identifiers
Resource Link UniProtKB ID Q9P0L9 UniProtKB Entry Name PK2L1_HUMAN HGNC ID HGNC:9011 - General References
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