Serine/threonine-protein kinase 26

Details

Name
Serine/threonine-protein kinase 26
Synonyms
  • 2.7.11.1
  • Mammalian STE20-like protein kinase 4
  • MASK
  • MST-4
  • MST3 and SOK1-related kinase
  • MST4
  • Serine/threonine-protein kinase MASK
  • STE20-like kinase MST4
Gene Name
STK26
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007835|Serine/threonine-protein kinase 26
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEA
EDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ
IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV
GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLV
GDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS
DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA
FAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
Number of residues
416
Molecular Weight
46528.395
Theoretical pI
4.93
GO Classification
Functions
ATP binding / identical protein binding / magnesium ion binding / protein homodimerization activity / protein kinase activity / protein serine/threonine kinase activity
Processes
activation of protein kinase activity / apoptotic process / cellular component disassembly involved in execution phase of apoptosis / microvillus assembly / programmed cell death / protein autophosphorylation / protein phosphorylation / regulation of apoptotic process / regulation of hydrogen peroxide-induced cell death / regulation of mitotic cell cycle / response to hydrogen peroxide / signal transduction by protein phosphorylation / stress-activated protein kinase signaling cascade
Components
apical plasma membrane / cell periphery / centrosome / cytoplasm / cytosol / extracellular exosome / Golgi apparatus / Golgi membrane / Golgi-associated vesicle / nucleus / perinuclear region of cytoplasm
General Function
Protein serine/threonine kinase activity
Specific Function
Mediator of cell growth. Modulates apoptosis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012862|Serine/threonine-protein kinase 26 (STK26)
ATGGCCCACTCGCCGGTGGCTGTCCAAGTGCCTGGGATGCAGAATAACATAGCTGATCCA
GAAGAACTGTTCACAAAATTAGAGCGCATTGGGAAAGGCTCATTTGGGGAAGTTTTCAAA
GGAATTGATAACCGTACCCAGCAAGTCGTTGCTATTAAAATCATAGACCTTGAGGAAGCC
GAAGATGAAATAGAAGACATTCAGCAAGAAATAACTGTCTTGAGTCAATGTGACAGCTCA
TATGTAACAAAATACTATGGGTCATATTTAAAGGGGTCTAAATTATGGATAATAATGGAA
TACCTGGGCGGTGGTTCAGCACTGGATCTTCTTCGAGCTGGTCCATTTGATGAGTTCCAG
ATTGCTACCATGCTAAAGGAAATTTTAAAAGGTCTGGACTATCTGCATTCAGAAAAGAAA
ATTCACCGAGACATAAAAGCTGCCAATGTCTTGCTCTCAGAACAAGGAGATGTTAAACTT
GCTGATTTTGGAGTTGCTGGTCAGCTGACAGATACACAGATTAAAAGAAATACCTTTGTG
GGAACTCCATTTTGGATGGCTCCTGAAGTTATTCAACAGTCAGCTTATGACTCAAAACGT
CCTACAGCAAAAGAACTTCTGAAACACAAATTCATTGTAAAAAATTCAAAGAAGACTTCT
TATCTGACTGAACTGATAGATCGTTTTAAGAGATGGAAGGCAGAAGGACACAGTGATGAT
GAATCTGATTCCGAGGGCTCTGATTCGGAATCTACCAGCAGGGAAAACAATACTCATCCT
GAATGGAGCTTTACCACCGTACGAAAGAAGCCTGATCCAAAGAAAGTACAGAATGGGGCA
GAGCAAGATCTTGTGCAAACCCTGAGTTGTTTGTCTATGATAATCACACCTGCATTTGCT
GAACTTAAACAGCAGGACGAGAATAACGCTAGCAGGAATCAGGCGATTGAAGAACTCGAG
AAAAGTATTGCTGTGGCTGAAGCCGCCTGTCCCGGCATCACAGATAAAATGGTGAAGAAA
CTAATTGAAAAATTTCAAAAGTGTTCAGCAGACGAATCCCCCTAA
Chromosome Location
X
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9P289
UniProtKB Entry NameSTK26_HUMAN
GenBank Protein ID13702675
GenBank Gene IDAF231012
HGNC IDHGNC:18174
General References
  1. Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM: MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene. 2001 Oct 4;20(45):6559-69. [Article]
  2. Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR: Cloning and characterization of MST4, a novel Ste20-like kinase. J Biol Chem. 2001 Jun 22;276(25):22439-45. Epub 2001 Apr 16. [Article]
  3. Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, Pandey A: Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties. J Biol Chem. 2002 Feb 22;277(8):5929-39. Epub 2001 Dec 6. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB078532-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrileexperimentalunknownDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails