V-1 protease
Details
- Name
- V-1 protease
- Synonyms
- Not Available
- Gene Name
- ORF
- Organism
- Human immunodeficiency virus 1
- Amino acid sequence
>lcl|BSEQ0019407|V-1 protease PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
- Number of residues
- 99
- Molecular Weight
- 10792.72
- Theoretical pI
- 8.77
- GO Classification
- Functionsaspartic-type endopeptidase activity
- General Function
- Aspartic-type endopeptidase activity
- Specific Function
- Not Available
- Pfam Domain Function
- RVP (PF00077)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0006492|297 bp CCTCAGATCACTCTTTGGCAACGACCCCTCGTCACAATAAAGATAGGGGGGCAACTAAAG GAAGCTCTATTAGATACAGGAGCAGATGATACAGTATTAGAAGAAATGTCCTTGCCAGGA AGATGGAAACCAAAAATGATAGGGGGAATTGGAGGTTTTATCAAAGTAAGACAGTATGAT CAGATACTCATAGAAATTTGTGGACATAAAGCTATAGGTACAGTACTAGTAGGACCTACA CCTGTCAACATAATTGGAAGAAATCTGTTGACTCAGATTGGTTGTACTTTAAATTTT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9Q2G8 UniProtKB Entry Name Q9Q2G8_9HIV1 GenBank Gene ID AJ279604 - General References
- Servais J, Lambert C, Fontaine E, Plesseria JM, Robert I, Arendt V, Staub T, Schneider F, Hemmer R, Burtonboy G, Schmit JC: Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor. Antimicrob Agents Chemother. 2001 Mar;45(3):893-900. [Article]
- Servais J, Lambert C, Fontaine E, Plesseria JM, Robert I, Arendt V, Staub T, Schneider F, Hemmer R, Burtonboy G, Schmit JC: Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy. J Clin Microbiol. 2001 Feb;39(2):454-9. [Article]
- Zhao C, Sham HL, Sun M, Stoll VS, Stewart KD, Lin S, Mo H, Vasavanonda S, Saldivar A, Park C, McDonald EJ, Marsh KC, Klein LL, Kempf DJ, Norbeck DW: Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5499-503. Epub 2005 Oct 3. [Article]
- Cihlar T, He GX, Liu X, Chen JM, Hatada M, Swaminathan S, McDermott MJ, Yang ZY, Mulato AS, Chen X, Leavitt SA, Stray KM, Lee WA: Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring. J Mol Biol. 2006 Oct 27;363(3):635-47. Epub 2006 Aug 2. [Article]
- Lafont V, Armstrong AA, Ohtaka H, Kiso Y, Mario Amzel L, Freire E: Compensating enthalpic and entropic changes hinder binding affinity optimization. Chem Biol Drug Des. 2007 Jun;69(6):413-22. [Article]
- Sanches M, Krauchenco S, Martins NH, Gustchina A, Wlodawer A, Polikarpov I: Structural characterization of B and non-B subtypes of HIV-protease: insights into the natural susceptibility to drug resistance development. J Mol Biol. 2007 Jun 15;369(4):1029-40. Epub 2007 Mar 24. [Article]