Mersacidin decarboxylase
Details
- Name
- Mersacidin decarboxylase
- Synonyms
- 4.1.1.-
- Mersacidin-modifying enzyme MrsD
- Gene Name
- mrsD
- Organism
- Bacillus sp. (strain HIL-Y85/54728)
- Amino acid sequence
>lcl|BSEQ0012097|Mersacidin decarboxylase MSISILKDKKLLIGICGSISSVGISSYLLYFKSFFKEIRVVMTKTAEDLIPAHTVSYFCD HVYSEHGENGKRHSHVEIGRWADIYCIIPATANILGQTANGVAMNLVATTVLAHPHNTIF FPNMNDLMWNKTVVSRNIEQLRKDGHIVIEPVEIMAFEIATGTRKPNRGLITPDKALLAI EKGFKERTKHPSLT
- Number of residues
- 194
- Molecular Weight
- 21677.045
- Theoretical pI
- 9.14
- GO Classification
- Functionslyase activity / oxidoreductase activityProcessesantibiotic biosynthetic process / oxidation-reduction process
- General Function
- Oxidoreductase activity
- Specific Function
- Catalyzes the oxidative decarboxylation of the C-terminal cysteine residue of mersacidin to an aminoenethiol residue.
- Pfam Domain Function
- Flavoprotein (PF02441)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0005842|585 bp TTATGTTAGTGAGGGGTGTTTTGTTCTTTCTTTAAAACCTTTTTCTATTGCTAATAAAGC TTTGTCGGGTGTAATTAGACCACGATTAGGTTTTCTTGTACCCGTCGCAATCTCAAACGC CATAATTTCAACTGGTTCAATAACAATATGCCCATCTTTTCTTAATTGTTCAATATTCCT GGAAACAACTGTTTTATTCCACATTAAATCGTTCATATTAGGAAAGAAAATAGTGTTATG TGGATGAGCTAATACAGTAGTTGCAACTAAATTCATTGCTACACCATTAGCAGTTTGTCC TAAGATGTTCGCTGTAGCTGGAATAATGCAATATATGTCCGCCCAGCGGCCAATTTCTAC GTGGCTATGTCTTTTTCCGTTTTCCCCATGTTCTGAGTATACATGGTCACAAAAATAAGA AACAGTATGAGCTGGAATAAGGTCTTCCGCTGTTTTTGTCATAACAACCCTTATTTCCTT AAAGAAGCTTTTAAAATATAAGAGATACGAGGAGATGCCGACAGATGAGATTGATCCGCA AATCCCGATCAATAACTTTTTATCTTTTAATATTGAAATACTCAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9RC23 UniProtKB Entry Name MRSD_BACSY GenBank Gene ID AJ250862 - General References
- Altena K, Guder A, Cramer C, Bierbaum G: Biosynthesis of the lantibiotic mersacidin: organization of a type B lantibiotic gene cluster. Appl Environ Microbiol. 2000 Jun;66(6):2565-71. [Article]
- Majer F, Schmid DG, Altena K, Bierbaum G, Kupke T: The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin. J Bacteriol. 2002 Mar;184(5):1234-43. [Article]
- Blaesse M, Kupke T, Huber R, Steinbacher S: Structure of MrsD, an FAD-binding protein of the HFCD family. Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1414-21. Epub 2003 Jul 23. [Article]