Phosphatidylinositol 4-kinase beta

Details

Name
Phosphatidylinositol 4-kinase beta
Synonyms
  • 2.7.1.67
  • NPIK
  • PI4K-beta
  • PI4K92
  • PIK4CB
Gene Name
PI4KB
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051904|Phosphatidylinositol 4-kinase beta
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
Number of residues
816
Molecular Weight
91378.045
Theoretical pI
Not Available
GO Classification
Functions
1-phosphatidylinositol 4-kinase activity / 14-3-3 protein binding / ATP binding
Processes
phosphatidylinositol biosynthetic process / phosphatidylinositol-mediated signaling / receptor-mediated endocytosis / signal transduction
Components
cytoplasm / cytosol / endosome / Golgi membrane / membrane / mitochondrial outer membrane / perinuclear region of cytoplasm / rough endoplasmic reticulum membrane
General Function
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
Specific Function
1-phosphatidylinositol 4-kinase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endomembrane system
Gene sequence
>lcl|BSEQ0051905|Phosphatidylinositol 4-kinase beta (PI4KB)
ATGGGAGATACAGTAGTGGAGCCTGCCCCCTTGAAGCCAACTTCTGAGCCCACTTCTGGC
CCACCAGGGAATAATGGGGGGTCCCTGCTAAGTGTCATCACGGAGGGGGTCGGGGAACTA
TCAGTGATTGACCCTGAGGTGGCCCAGAAGGCCTGCCAGGAGGTGTTGGAGAAAGTCAAG
CTTTTGCATGGAGGCGTGGCAGTCTCTAGCAGAGGCACCCCACTGGAGTTGGTCAATGGG
GATGGTGTGGACAGTGAGATCCGTTGCCTAGATGATCCACCTGCCCAGATCAGGGAGGAG
GAAGATGAGATGGGGGCCGCTGTGGCCTCAGGCACAGCCAAAGGAGCAAGAAGACGGCGG
CAGAACAACTCAGCTAAACAGTCTTGGCTGCTGAGGCTGTTTGAGTCAAAACTGTTTGAC
ATCTCCATGGCCATTTCATACCTGTATAACTCCAAGGAGCCTGGAGTACAAGCCTACATT
GGCAACCGGCTCTTCTGCTTTCGCAACGAGGACGTGGACTTCTATCTGCCCCAGTTGCTT
AACATGTACATCCACATGGATGAGGACGTGGGTGATGCCATTAAGCCCTACATAGTCCAC
CGTTGCCGCCAGAGCATTAACTTTTCCCTCCAGTGTGCCCTGTTGCTTGGGGCCTATTCT
TCAGACATGCACATTTCCACTCAACGACACTCCCGTGGGACCAAGCTACGGAAGCTGATC
CTCTCAGATGAGCTAAAGCCAGCTCACAGGAAGAGGGAGCTGCCCTCCTTGAGCCCGGCC
CCTGACACAGGGCTGTCTCCCTCCAAAAGGACTCACCAGCGCTCTAAGTCAGATGCCACT
GCCAGCATAAGTCTCAGCAGCAACCTGAAACGAACAGCCAGCAACCCTAAAGTGGAGAAT
GAGGATGAGGAGCTCTCCTCCAGCACCGAGAGTATTGATAATTCATTCAGTTCCCCTGTT
CGACTGGCTCCTGAGAGAGAATTCATCAAGTCCCTGATGGCGATCGGCAAGCGGCTGGCC
ACGCTCCCCACCAAAGAGCAGAAAACACAGAGGCTGATCTCAGAGCTCTCCCTGCTCAAC
CATAAGCTCCCTGCCCGAGTCTGGCTGCCCACTGCTGGCTTTGACCACCACGTGGTCCGT
GTACCCCACACACAGGCTGTTGTCCTCAACTCCAAGGACAAGGCTCCCTACCTGATTTAT
GTGGAAGTCCTTGAATGTGAAAACTTTGACACCACCAGTGTCCCTGCCCGGATCCCCGAG
AACCGAATTCGGAGTACGAGGTCCGTAGAAAACTTGCCCGAATGTGGTATTACCCATGAG
CAGCGAGCTGGCAGCTTCAGCACTGTGCCCAACTATGACAACGATGATGAGGCCTGGTCG
GTGGATGACATAGGCGAGCTGCAAGTGGAGCTCCCCGAAGTGCATACCAACAGCTGTGAC
AACATCTCCCAGTTCTCTGTGGACAGCATCACCAGCCAGGAGAGCAAGGAGCCTGTGTTC
ATTGCAGCAGGGGACATCCGCCGGCGCCTTTCGGAACAGCTGGCTCATACCCCGACAGCC
TTCAAACGAGACCCAGAAGATCCTTCTGCAGTTGCTCTCAAAGAGCCCTGGCAGGAGAAA
GTACGGCGGATCAGAGAGGGCTCCCCCTACGGCCATCTCCCCAATTGGCGGCTCCTGTCA
GTCATTGTCAAGTGTGGGGATGACCTTCGGCAAGAGCTTCTGGCCTTTCAGGTGTTGAAG
CAACTGCAGTCCATTTGGGAACAGGAGCGAGTGCCCCTTTGGATCAAGCCATACAAGATT
CTTGTGATTTCGGCTGATAGTGGCATGATTGAACCAGTGGTCAATGCTGTGTCCATCCAT
CAGGTGAAGAAACAGTCACAGCTCTCCTTGCTCGATTACTTCCTACAGGAGCACGGCAGT
TACACCACTGAGGCATTCCTCAGTGCACAGCGCAATTTTGTGCAAAGTTGTGCTGGGTAC
TGCTTGGTCTGCTACCTGCTGCAAGTCAAGGACAGACACAATGGGAATATCCTTTTGGAC
GCAGAAGGCCACATCATCCACATCGACTTTGGCTTCATCCTCTCCAGCTCACCCCGAAAT
CTGGGCTTTGAGACGTCAGCCTTTAAGCTGACCACAGAGTTTGTGGATGTGATGGGCGGC
CTGGATGGCGACATGTTCAACTACTATAAGATGCTGATGCTGCAAGGGCTGATTGCCGCT
CGGAAACACATGGACAAGGTGGTGCAGATCGTGGAGATCATGCAGCAAGGTTCTCAGCTT
CCTTGCTTCCATGGCTCCAGCACCATTCGAAACCTCAAAGAGAGGTTCCACATGAGCATG
ACTGAGGAGCAGCTGCAGCTGCTGGTGGAGCAGATGGTGGATGGCAGTATGCGGTCTATC
ACCACCAAACTCTATGACGGCTTCCAGTACCTCACCAACGGCATCATGTGA
Chromosome Location
1
Locus
1q21.3
External Identifiers
ResourceLink
UniProtKB IDQ9UBF8
UniProtKB Entry NamePI4KB_HUMAN
HGNC IDHGNC:8984
General References
  1. Suzuki K, Hirano H, Okutomi K, Suzuki M, Kuga Y, Fujiwara T, Kanemoto N, Isono K, Horie M: Identification and characterization of a novel human phosphatidylinositol 4-kinase. DNA Res. 1997 Aug 31;4(4):273-80. [Article]
  2. Saito T, Seki N, Ishii H, Ohira M, Hayashi A, Kozuma S, Hori T: Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene. DNA Res. 1997 Aug 31;4(4):301-5. [Article]
  3. Meyers R, Cantley LC: Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem. 1997 Feb 14;272(7):4384-90. [Article]
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  7. Greninger AL, Knudsen GM, Betegon M, Burlingame AL, DeRisi JL: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. MBio. 2013 Apr 9;4(2):e00098-13. doi: 10.1128/mBio.00098-13. [Article]
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  19. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
  20. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
  21. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  22. McPhail JA, Ottosen EH, Jenkins ML, Burke JE: The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIbeta, PI4KB, through ACBD3. Structure. 2017 Jan 3;25(1):121-131. doi: 10.1016/j.str.2016.11.016. Epub 2016 Dec 15. [Article]
  23. Klima M, Toth DJ, Hexnerova R, Baumlova A, Chalupska D, Tykvart J, Rezabkova L, Sengupta N, Man P, Dubankova A, Humpolickova J, Nencka R, Veverka V, Balla T, Boura E: Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein. Sci Rep. 2016 Mar 24;6:23641. doi: 10.1038/srep23641. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails