P2X purinoceptor 2
Details
- Name
- P2X purinoceptor 2
- Synonyms
- ATP receptor
- P2X2
- Purinergic receptor
- Gene Name
- P2RX2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052223|P2X purinoceptor 2 MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYV FIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQ TQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVED GASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFK LGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYN FRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCD WILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSG QEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
- Number of residues
- 471
- Molecular Weight
- 51753.75
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / extracellularly ATP-gated cation channel activity / identical protein binding / ligand-gated ion channel activity / purinergic nucleotide receptor activityProcessesbehavioral response to pain / blood coagulation / detection of hypoxic conditions in blood by carotid body chemoreceptor signaling / neuromuscular junction development / neuromuscular synaptic transmission / peristalsis / positive regulation of calcium ion transport into cytosol / positive regulation of calcium-mediated signaling / response to ATP / response to carbohydrate / response to hypoxia / response to ischemia / sensory perception of sound / sensory perception of taste / skeletal muscle fiber development / urinary bladder smooth muscle contractionComponentsapical plasma membrane / cell / integral component of nuclear inner membrane / integral component of plasma membrane / neuronal cell body / plasma membrane / postsynapse / receptor complex
- General Function
- Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
- Specific Function
- Atp binding
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- 43-63 338-358
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052224|P2X purinoceptor 2 (P2RX2) ATGGCCGCCGCCCAGCCCAAGTACCCCGCCGGGGCGACCGCCCGGCGCCTGGCCCGGGGC TGCTGGTCCGCCCTCTGGGACTACGAGACGCCCAAGGTGATCGTGGTGAGGAACCGGCGC CTGGGGGTCCTGTACCGCGCCGTGCAGCTGCTCATCCTGCTCTACTTCGTGTGGTACGTA TTCATCGTGCAGAAAAGCTACCAGGAGAGCGAGACGGGCCCCGAGAGCTCCATCATCACC AAGGTCAAGGGGATCACCACGTCCGAGCACAAAGTGTGGGACGTGGAGGAGTACGTGAAG CCCCCCGAGGGGGGCAGCGTGTTCAGCATCATCACCAGGGTCGAGGCCACCCACTCCCAG ACCCAGGGAACCTGCCCCGAGAGCATAAGGGTCCACAACGCCACCTGCCTCTCCGACGCC GACTGCGTGGCTGGGGAGCTGGACATGCTGGGAAACGGCCTGAGGACTGGGCGCTGTGTG CCCTATTACCAGGGGCCCTCCAAGACCTGCGAGGTGTTCGGCTGGTGCCCGGTGGAAGAT GGGGCCTCTGTCAGCCAATTTCTGGGTACGATGGCCCCAAATTTCACCATCCTCATCAAG AACAGCATCCACTACCCCAAATTCCACTTCTCCAAGGGCAACATCGCCGACCGCACAGAC GGGTACCTGAAGCGCTGCACGTTCCACGAGGCCTCCGACCTCTACTGCCCCATCTTCAAG CTGGGCTTTATCGTGGAGAAGGCTGGGGAGAGCTTCACAGAGCTCGCACACAAGGGTGGT GTCATCGGGGTCATTATCAACTGGGACTGTGACCTGGACCTGCCTGCATCGGAGTGCAAC CCCAAGTACTCCTTCCGGAGGCTTGACCCCAAGCACGTGCCTGCCTCGTCAGGCTACAAC TTCAGGTTTGCCAAATACTACAAGATCAATGGCACCACCACCCGCACGCTCATCAAGGCC TACGGGATCCGCATTGACGTCATTGTGCATGGACAGGCCGGGAAGTTCAGCCTGATTCCC ACCATTATTAATCTGGCCACAGCTCTGACTTCCGTCGGGGTGGGCTCCTTCCTGTGCGAC TGGATCTTGCTAACATTCATGAACAAAAACAAGGTCTACAGCCATAAGAAATTTGACAAG GTGTGTACGCCGAGCCACCCCTCAGGTAGCTGGCCTGTGACCCTTGCCCGTGTATTGGGC CAGGCCCCTCCCGAACCCGGCCACCGCTCCGAGGACCAGCACCCCAGCCCTCCATCAGGC CAGGAGGGCCAACAAGGGGCAGAGTGTGGCCCAGCCTTCCCGCCCCTGCGGCCTTGCCCC ATCTCTGCCCCTTCTGAGCAGATGGTGGACACTCCTGCCTCCGAGCCTGCCCAAGCCTCC ACACCCACAGACCCCAAAGGTTTGGCTCAACTCTGA
- Chromosome Location
- 12
- Locus
- 12q24.33
- External Identifiers
Resource Link UniProtKB ID Q9UBL9 UniProtKB Entry Name P2RX2_HUMAN HGNC ID HGNC:15459 - General References
- Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF: Molecular and functional characterization of human P2X(2) receptors. Mol Pharmacol. 1999 Dec;56(6):1171-81. doi: 10.1124/mol.56.6.1171. [Article]
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- Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ: Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2228-33. doi: 10.1073/pnas.1222285110. Epub 2013 Jan 23. [Article]
- Faletra F, Girotto G, D'Adamo AP, Vozzi D, Morgan A, Gasparini P: A novel P2RX2 mutation in an Italian family affected by autosomal dominant nonsyndromic hearing loss. Gene. 2014 Jan 25;534(2):236-9. doi: 10.1016/j.gene.2013.10.052. Epub 2013 Nov 6. [Article]