Cell surface hyaluronidase
Details
- Name
- Cell surface hyaluronidase
- Synonyms
- 3.2.1.35
- Cell migration-inducing hyaluronidase 2
- KIAA1412
- TMEM2
- Transmembrane protein 2
- Gene Name
- CEMIP2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052539|Cell surface hyaluronidase MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATF AFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRL RNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYIL IQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASW TLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEF LRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTS CNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNL LDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVD MRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMG QQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDT LGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCM AVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNR VHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAF KNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGF QGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIG FLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGY KDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPM VLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTS FQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHG HSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQV VFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLT EKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGS TIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQAS KAH
- Number of residues
- 1383
- Molecular Weight
- 154372.57
- Theoretical pI
- Not Available
- GO Classification
- Functionscadherin binding / calcium ion binding / hyalurononglucosaminidase activityProcessesangiogenesis / hyaluronan catabolic process / regulation of sprouting angiogenesisComponentsextracellular exosome / integral component of membrane / integral component of plasma membrane / intracellular membrane-bounded organelle / plasma membrane
- General Function
- Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).
- Specific Function
- Cadherin binding
- Pfam Domain Function
- Transmembrane Regions
- 83-103
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052540|Cell surface hyaluronidase (CEMIP2) ATGTATGCCACTGATTCCAGGGGACACTCCCCTGCTTTCCTCCAACCTCAGAATGGAAAT AGTCGTCACCCATCTGGCTATGTTCCAGGGAAGGTTGTCCCATTGCGTCCCCCTCCTCCT CCAAAGAGTCAAGCTTCAGCCAAATTTACCTCCATCAGACGAGAAGACCGGGCAACCTTC GCATTCTCACCTGAAGAACAGCAAGCCCAGAGAGAAAGTCAAAAGCAAAAGAGACACAAA AATACTTTCATTTGTTTTGCTATTACTAGTTTCTCATTTTTTATTGCACTTGCAATCATT TTAGGAATATCCTCAAAATATGCTCCAGATGAAAATTGCCCAGATCAAAATCCTCGTCTC AGGAATTGGGATCCAGGACAAGATTCTGCAAAGCAAGTTGTTATCAAGGAGGGAGATATG CTCCGTCTGACCTCAGACGCCACCGTGCATTCTATAGTCATTCAGGATGGAGGACTGCTT GTATTTGGGGACAATAAAGATGGATCCAGAAATATTACTTTGAGGACTCATTACATCCTG ATCCAGGATGGTGGGGCGCTTCATATTGGAGCAGAAAAATGCCGCTATAAATCCAAAGCG ACAATTACCTTGTATGGCAAGTCAGATGAAGGTGAAAGTATGCCAACATTTGGCAAAAAG TTTATTGGTGTGGAAGCTGGCGGGACACTGGAGTTACATGGGGCACGGAAGGCATCGTGG ACGTTGTTGGCAAGGACCCTGAATTCCTCAGGCTTGCCCTTTGGGTCCTATACCTTTGAA AAGGACTTTTCCCGGGGCCTCAATGTGAGGGTCATTGACCAAGACACGGCCAAAATTTTG GAAAGTGAGAGATTTGATACCCATGAATACCGCAATGAGAGCAGGCGGCTTCAGGAGTTT CTGAGATTCCAGGATCCAGGTCGGATTGTTGCCATAGCTGTCGGGGATTCAGCCGCTAAA AGTCTCTTACAAGGAACCATCCAGATGATCCAGGAACGGTTGGGAAGTGAACTGATCCAA GGACTGGGCTACAGGCAAGCTTGGGCTTTAGTTGGTGTCATTGATGGTGGAAGCACTTCT TGCAATGAATCCGTGAGAAACTATGAAAATCATAGCAGTGGCGGGAAGGCTCTTGCCCAA AGAGAATTTTATACTGTGGATGGCCAGAAGTTCTCTGTGACAGCTTATAGTGAATGGATT GAAGGCGTTTCTCTTTCAGGATTCCGGGTAGAGGTTGTAGATGGAGTGAAGCTAAATTTG CTAGATGATGTTAGTAGTTGGAAACCTGGAGACCAGATTGTGGTCGCAAGCACAGACTAT TCCATGTACCAAGCAGAGGAGTTCACTCTTCTTCCCTGTTCTGAATGCAGCCATTTTCAG GTCAAAGTCAAAGAAACCCCTCAGTTCCTGCACATGGGTGAGATCATAGACGGTGTAGAC ATGAGAGCTGAGGTTGGAATTCTTACCCGGAATATTGTGATCCAAGGAGAAGTGGAGGAC TCATGCTACGCAGAAAATCAGTGCCAATTTTTTGATTATGATACCTTTGGGGGACACATT ATGATAATGAAAAATTTTACTTCAGTCCATCTTTCTTATGTGGAATTGAAACACATGGGT CAGCAGCAGATGGGGCGATACCCTGTTCATTTTCACCTGTGTGGTGACGTGGATTATAAA GGAGGATACAGACATGCAACATTTGTGGACGGCCTGTCTATTCATCACAGCTTCTCAAGG TGCATCACTGTGCATGGGACAAATGGCTTGCTAATAAAAGACACCATTGGGTTTGACACA CTAGGTCATTGTTTCTTTTTGGAAGATGGTATTGAACAGAGGAATACTTTGTTCCACAAT CTGGGACTCCTCACCAAGCCGGGTACTCTCCTGCCCACCGATAGGAACAACTCCATGTGT ACCACCATGCGAGATAAAGTGTTTGGAAATTACATTCCTGTGCCTGCTACTGACTGTATG GCTGTTTCAACTTTCTGGATTGCTCATCCCAACAATAATCTGATTAATAATGCAGCTGCA GGCTCACAGGATGCTGGAATATGGTATTTATTCCACAAGGAACCAACTGGGGAATCCAGT GGATTGCAGCTCTTGGCAAAACCAGAACTCACTCCATTGGGTATATTTTATAACAACAGG GTCCATTCAAATTTTAAGGCTGGCTTATTTATTGACAAAGGTGTCAAAACAACCAACTCT AGTGCTGCTGACCCAAGGGAATACCTCTGTTTGGACAATAGTGCAAGATTTCGACCTCAT CAGGATGCAAACCCCGAAAAACCACGTGTTGCTGCTCTAATTGACAGGCTCATTGCTTTT AAAAATAATGATAATGGAGCTTGGGTCAGAGGAGGAGATATTATCGTTCAAAATTCAGCA TTTGCAGATAATGGAATAGGACTGACCTTTGCCAGTGATGGAAGCTTCCCAAGTGATGAA GGTTCCAGCCAAGAGGTATCTGAATCTCTCTTTGTTGGGGAGAGCAGGAATTACGGCTTT CAGGGTGGTCAGAACAAGTATGTAGGCACTGGAGGAATAGACCAGAAGCCTCGAACATTA CCCAGGAACAGGACGTTCCCAATTAGAGGCTTTCAGATTTATGATGGGCCCATTCATCTC ACAAGGAGCACTTTCAAAAAATATGTGCCAACTCCAGATAGGTACAGCAGTGCAATTGGC TTCCTCATGAAGAATTCCTGGCAGATAACCCCCAGGAATAATATCTCCCTCGTGAAGTTT GGTCCACATGTCTCTCTGAATGTCTTTTTTGGAAAGCCTGGTCCCTGGTTTGAAGATTGT GAGATGGATGGTGATAAGAACTCCATATTCCATGACATTGATGGCTCTGTGACAGGATAC AAGGATGCTTATGTGGGAAGAATGGACAACTACCTGATCCGCCATCCAAGCTGTGTAAAT GTGTCTAAGTGGAATGCAGTGATCTGCAGTGGGACCTATGCACAGGTCTATGTACAGACA TGGAGCACTCAGAATCTTTCTATGACCATTACACGAGATGAGTATCCGTCCAACCCTATG GTGCTCCGAGGTATTAATCAGAAGGCTGCCTTTCCACAGTACCAGCCTGTCGTCATGCTG GAGAAGGGTTATACCATCCACTGGAATGGGCCGGCACCACGGACTACATTTCTATACCTC GTCAACTTCAACAAGAATGACTGGATTCGAGTTGGCCTTTGCTATCCATCAAACACAAGT TTTCAAGTTACCTTTGGCTATTTGCAGCGGCAGAATGGCTCATTATCCAAAATCGAAGAA TATGAGCCTGTGCATTCACTGGAAGAACTGCAAAGAAAGCAATCCGAGAGGAAATTCTAT TTTGACTCCAGCACGGGGTTACTGTTTTTGTATCTCAAAGCCAAAAGCCACAGGCATGGC CACAGTTACTGTTCATCTCAGGGATGTGAAAGAGTCAAGATCCAAGCAGCCACAGACTCA AAGGACATCAGTAACTGCATGGCCAAAGCATACCCACAGTACTACAGAAAGCCGTCAGTG GTCAAGCGGATGCCGGCCATGCTCACTGGACTCTGTCAAGGCTGTGGCACTCGGCAGGTG GTGTTTACTAGTGATCCTCATAAAAGTTACCTCCCTGTGCAATTCCAGTCACCTGATAAA GCAGAAACCCAGCGTGGAGACCCGTCTGTTATTTCTGTCAATGGCACTGACTTTACCTTC CGAAGTGCAGGCGTCCTCCTCCTTGTTGTGGATCCGTGCAGCGTTCCATTCCGCTTGACG GAAAAAACGGTTTTTCCTCTTGCTGATGTCAGTCGCATTGAAGAGTATTTAAAAACAGGC ATCCCTCCAAGGTCCATTGTTCTGTTGAGCACAAGAGGAGAAATAAAGCAGTTAAACATT TCACACTTACTAGTACCTCTGGGATTAGCCAAACCAGCTCATCTTTATGACAAAGGGAGT ACCATATTTTTGGGATTCAGTGGAAACTTTAAACCATCATGGACTAAGCTATTTACCAGT CCTGCTGGACAGGGCCTTGGGGTGCTTGAACAATTCATACCTTTGCAGCTGGACGAATAT GGTTGTCCCAGAGCCACCACTGTCCGCAGAAGAGACCTGGAACTGCTAAAGCAAGCTTCA AAAGCACATTAG
- Chromosome Location
- 9
- Locus
- 9q21.13
- External Identifiers
Resource Link UniProtKB ID Q9UHN6 UniProtKB Entry Name CEIP2_HUMAN HGNC ID HGNC:11869 - General References
- Scott DA, Drury S, Sundstrom RA, Bishop J, Swiderski RE, Carmi R, Ramesh A, Elbedour K, Srikumari Srisailapathy CR, Keats BJ, Sheffield VC, Smith RJ: Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. Gene. 2000 Apr 4;246(1-2):265-74. doi: 10.1016/s0378-1119(00)00090-1. [Article]
- Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [Article]
- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [Article]
- Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Yamamoto H, Tobisawa Y, Inubushi T, Irie F, Ohyama C, Yamaguchi Y: A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase. J Biol Chem. 2017 May 5;292(18):7304-7313. doi: 10.1074/jbc.M116.770149. Epub 2017 Feb 28. [Article]