Potassium voltage-gated channel subfamily G member 1

Details

Name

Potassium voltage-gated channel subfamily G member 1

Synonyms

• kH2
• Voltage-gated potassium channel subunit Kv6.1

Gene Name

KCNG1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052255|Potassium voltage-gated channel subfamily G member 1
MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPED
RRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRN
PGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMV
EREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVT
AVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSP
LTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHS
LGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVI
TMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFR
RAQFLIKTKSQLSVSQDSDILFGSASSDTRDNN

Number of residues

513

Molecular Weight

57912.07

Theoretical pI

Not Available

GO Classification

Functions

delayed rectifier potassium channel activity / potassium channel activity / voltage-gated potassium channel activity

Processes

potassium ion transmembrane transport / potassium ion transport / protein homooligomerization / regulation of delayed rectifier potassium channel activity

Components

integral component of membrane / plasma membrane / voltage-gated potassium channel complex

General Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).

Specific Function

Delayed rectifier potassium channel activity

Pfam Domain Function

• Ion_trans (PF00520)
• BTB_2 (PF02214)

Transmembrane Regions

225-246 268-289 301-321 339-359 375-396 439-467

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0052256|Potassium voltage-gated channel subfamily G member 1 (KCNG1)
ATGACCCTCTTACCGGGAGACAATTCTGACTACGACTACAGCGCGCTGAGCTGCACCTCG
GACGCCTCCTTCCACCCGGCCTTCCTCCCGCAGCGCCAGGCCATCAAGGGCGCGTTCTAC
CGCCGGGCGCAGCGGCTGCGGCCGCAGGATGAGCCCCGCCAGGGCTGTCAGCCCGAGGAC
CGCCGCCGTCGGATCATCATCAACGTAGGCGGCATCAAGTACTCGCTGCCCTGGACCACG
CTGGACGAGTTCCCGCTGACGCGCCTGGGCCAGCTCAAGGCCTGCACCAACTTCGACGAC
ATCCTCAACGTGTGCGATGACTACGACGTCACCTGCAACGAGTTCTTCTTCGACCGCAAC
CCGGGGGCCTTCGGCACTATCCTGACCTTCCTGCGCGCGGGCAAGCTGCGGCTGCTGCGC
GAGATGTGCGCGCTGTCCTTCCAGGAGGAGCTGCTGTACTGGGGCATCGCGGAGGACCAC
CTGGACGGCTGCTGCAAGCGCCGCTACCTGCAGAAGATTGAGGAGTTCGCGGAGATGGTG
GAGCGGGAGGAAGAGGACGACGCGCTGGACAGCGAGGGCCGCGACAGCGAGGGCCCGGCC
GAGGGCGAGGGCCGCCTGGGGCGCTGCATGCGGCGACTGCGCGACATGGTGGAGAGGCCG
CACTCGGGGCTGCCTGGCAAGGTGTTCGCCTGCCTGTCGGTGCTCTTCGTGACCGTCACC
GCCGTCAACCTCTCCGTCAGCACCTTGCCCAGCCTGAGGGAGGAGGAGGAGCAGGGCCAC
TGTTCCCAGATGTGCCACAACGTCTTCATCGTGGAGTCGGTGTGCGTGGGCTGGTTCTCC
CTGGAGTTCCTCCTGCGGCTCATTCAGGCGCCCAGCAAGTTCGCCTTCCTGCGGAGCCCG
CTGACGCTGATCGACCTGGTGGCCATCCTGCCCTACTACATCACGCTGCTGGTGGACGGC
GCCGCCGCAGGCCGTCGCAAGCCCGGCGCGGGCAACAGCTACCTGGACAAGGTGGGGCTG
GTGCTGCGCGTGCTGCGGGCGCTGCGCATCCTGTACGTGATGCGCCTGGCGCGCCACTCC
CTGGGGCTGCAGACGCTGGGGCTCACGGCCCGCCGCTGCACCCGCGAGTTCGGGCTCCTG
CTGCTCTTCCTCTGCGTGGCCATCGCCCTCTTCGCGCCCCTGCTCTACGTCATCGAGAAC
GAGATGGCCGACAGCCCCGAGTTCACCAGCATCCCTGCCTGCTACTGGTGGGCTGTCATC
ACCATGACGACGGTGGGCTATGGCGACATGGTCCCCAGGAGCACCCCGGGCCAGGTAGTG
GCCCTGAGCAGCATCCTGAGCGGCATCCTGCTCATGGCCTTCCCAGTCACCTCCATCTTC
CACACCTTCTCCCGCTCCTACCTGGAGCTCAAGCAGGAGCAAGAGAGGGTGATGTTCCGG
AGGGCGCAGTTCCTCATCAAAACCAAGTCGCAGCTGAGCGTGTCCCAGGACAGTGACATC
TTGTTCGGAAGTGCCTCCTCGGACACCAGAGACAATAACTGA

Chromosome Location

20

Locus

20q13.13

External Identifiers

Resource	Link
UniProtKB ID	Q9UIX4
UniProtKB Entry Name	KCNG1_HUMAN
HGNC ID	HGNC:6248

General References

1. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y: Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun. 1997 Dec 29;241(3):675-81. [Article]
2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
3. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
5. Mederos Y Schnitzler M, Rinne S, Skrobek L, Renigunta V, Schlichthorl G, Derst C, Gudermann T, Daut J, Preisig-Muller R: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem. 2009 Feb 13;284(7):4695-704. doi: 10.1074/jbc.M808786200. Epub 2008 Dec 11. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00228	Enflurane	approved, investigational, vet_approved	unknown	inhibitoractivator	Details
DB01069	Promethazine	approved, investigational	unknown	inducer	Details
DB01110	Miconazole	approved, investigational, vet_approved	unknown	inhibitor	Details