N-acetyl-D-glucosamine kinase
Details
- Name
- N-acetyl-D-glucosamine kinase
- Synonyms
- 2.7.1.59
- GlcNAc kinase
- N-acetylglucosamine kinase
- Gene Name
- NAGK
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004446|N-acetyl-D-glucosamine kinase MAAIYGGVEGGGTRSEVLLVSEDGKILAEADGLSTNHWLIGTDKCVERINEMVNRAKRKA GVDPLVPLRSLGLSLSGGDQEDAGRILIEELRDRFPYLSESYLITTDAAGSIATATPDGG VVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHD IGYVKQAMFHYFQVPDRLGILTHLYRDFDKCRFAGFCRKIAEGAQQGDPLSRYIFRKAGE MLGRHIVAVLPEIDPVLFQGKIGLPILCVGSVWKSWELLKEGFLLALTQGREIQAQNFFS SFTLMKLRHSSALGGASLGARHIGHLLPMDYSANAIAFYSYTFS
- Number of residues
- 344
- Molecular Weight
- 37375.305
- Theoretical pI
- 6.18
- GO Classification
- FunctionsATP binding / N-acetylglucosamine kinase activity / N-acylmannosamine kinase activityProcessescarbohydrate phosphorylation / N-acetylglucosamine metabolic process / N-acetylmannosamine metabolic process / N-acetylneuraminate catabolic processComponentsextracellular exosome
- General Function
- N-acylmannosamine kinase activity
- Specific Function
- Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity.
- Pfam Domain Function
- BcrAD_BadFG (PF01869)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016735|N-acetyl-D-glucosamine kinase (NAGK) ATGCGCACGCGCACAGGGAGTCAGCTGGCTGCGCGGGAGGTCACGGGAAGTGGGGCGGTG CCCAGACAGCTGGAGGGAAGGAGGTGTCAGGCGGGGAGAGACGCAAACGGCGGGACCAGC AGCGACGGTAGCAGCAGCATGGCCGCGATCTATGGGGGTGTAGAGGGGGGAGGCACACGA TCCGAGGTCCTTTTAGTCTCAGAGGATGGGAAGATCCTGGCAGAAGCAGATGGACTGAGC ACAAACCACTGGCTGATCGGGACAGACAAGTGTGTGGAGAGGATCAATGAGATGGTGAAC AGGGCCAAACGGAAAGCAGGGGTGGATCCTCTGGTACCGCTGCGAAGCTTGGGCCTATCT CTGAGCGGTGGGGACCAGGAGGACGCGGGGAGGATCCTGATCGAGGAGCTGAGGGACCGA TTTCCCTACCTGAGTGAAAGCTACTTAATCACCACCGATGCCGCCGGCTCCATCGCCACA GCTACACCGGATGGTGGAGTTGTGCTCATATCTGGAACAGGCTCCAACTGCAGGCTCATC AACCCTGATGGCTCCGAGAGTGGCTGCGGCGGCTGGGGCCATATGATGGGTGATGAGGGT TCAGCCTACTGGATCGCACACCAAGCAGTGAAAATAGTGTTTGACTCCATTGACAACCTA GAGGCGGCTCCTCATGATATCGGCTACGTCAAACAGGCCATGTTCCACTATTTCCAGGTG CCAGATCGGCTAGGGATACTCACTCACCTGTATAGGGACTTTGATAAATGCAGGTTTGCT GGGTTTTGCCGGAAAATTGCAGAAGGTGCTCAGCAGGGAGACCCCCTTTCCCGCTATATC TTCAGGAAGGCTGGGGAGATGCTGGGCAGACACATCGTAGCAGTGTTGCCCGAGATTGAC CCGGTCTTGTTCCAGGGCAAGATTGGACTCCCCATCCTGTGCGTGGGCTCTGTGTGGAAG AGCTGGGAGCTGCTGAAGGAAGGTTTTCTTCTGGCGCTGACCCAGGGCAGAGAGATCCAG GCTCAGAACTTCTTCTCCAGCTTCACCCTGATGAAGCTGAGGCACTCCTCCGCTCTGGGT GGGGCCAGCCTAGGGGCCAGGCACATCGGGCACCTCCTCCCCATGGACTATAGCGCCAAT GCCATTGCCTTCTATTCCTACACCTTTTCCTAG
- Chromosome Location
- 2
- Locus
- 2p13.3
- External Identifiers
Resource Link UniProtKB ID Q9UJ70 UniProtKB Entry Name NAGK_HUMAN GenBank Protein ID 6491737 GenBank Gene ID AJ242910 GenAtlas ID NAGK HGNC ID HGNC:17174 - General References
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