Serine/threonine-protein kinase TAO2

Details

Name
Serine/threonine-protein kinase TAO2
Synonyms
  • 2.7.11.1
  • hKFC-C
  • KIAA0881
  • Kinase from chicken homolog C
  • MAP3K17
  • Prostate-derived STE20-like kinase 1
  • Prostate-derived sterile 20-like kinase 1
  • PSK
  • PSK-1
  • PSK1
  • Thousand and one amino acid protein kinase 2
Gene Name
TAOK2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009551|Serine/threonine-protein kinase TAO2
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP
GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ
EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE
KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE
NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD
LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY
NKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQ
EAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVW
GLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPE
EEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVG
SSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLL
AQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRG
ISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTT
QHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPR
SQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR
Number of residues
1235
Molecular Weight
138250.17
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / MAP kinase kinase kinase activity / mitogen-activated protein kinase kinase binding / protein serine/threonine kinase activity
Processes
actin cytoskeleton organization / activation of MAPKK activity / apoptotic process / cell migration / cellular response to DNA damage stimulus / focal adhesion assembly / G2 DNA damage checkpoint / positive regulation of JNK cascade / positive regulation of stress-activated MAPK cascade / protein targeting to membrane / regulation of apoptotic process / regulation of cell growth / regulation of cell shape / regulation of mitotic cell cycle / response to stress / stress-activated MAPK cascade
Components
cytoplasm / cytoplasmic membrane-bounded vesicle / cytoplasmic vesicle membrane / cytoskeleton / dendrite / integral component of membrane / nucleolus / nucleus / receptor complex
General Function
Protein serine/threonine kinase activity
Specific Function
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
Pfam Domain Function
Transmembrane Regions
965-985 987-1007 1012-1032 1043-1063 1166-1186
Cellular Location
Cytoplasmic vesicle membrane
Gene sequence
>lcl|BSEQ0021713|Serine/threonine-protein kinase TAO2 (TAOK2)
ATGCCAGCTGGGGGCCGGGCCGGGAGCCTGAAGGACCCAGATGTGGCTGAGCTCTTCTTC
AAGGATGACCCAGAAAAGCTCTTCTCTGACCTCCGGGAAATTGGCCATGGCAGCTTTGGA
GCCGTATACTTTGCCCGGGATGTCCGGAATAGTGAGGTGGTGGCCATCAAGAAGATGTCC
TACAGTGGGAAGCAGTCCAATGAGAAATGGCAAGACATCATCAAGGAGGTGCGGTTCTTA
CAGAAGCTCCGGCATCCCAACACCATTCAGTACCGGGGCTGTTACCTGAGGGAGCACACG
GCTTGGCTGGTAATGGAGTATTGCCTGGGCTCAGCTTCTGACCTTCTAGAAGTGCACAAG
AAACCCCTTCAGGAGGTAGAGATCGCAGCTGTGACCCACGGGGCGCTTCAGGGCCTGGCA
TATCTGCACTCCCACAACATGATCCATAGGGATGTGAAGGCTGGAAACATCCTGCTGTCA
GAGCCAGGGTTAGTGAAGCTAGGGGACTTTGGTTCTGCGTCCATCATGGCACCTGCCAAC
TCCTTCGTGGGCACCCCATACTGGATGGCACCCGAGGTGATCCTGGCCATGGATGAGGGG
CAGTACGATGGCAAAGTGGACGTCTGGTCCTTGGGGATAACCTGCATCGAGCTGGCTGAA
CGGAAACCACCGCTCTTTAACATGAATGCGATGAGTGCCTTATACCACATTGCACAGAAC
GAATCCCCCGTGCTCCAGTCAGGACACTGGTCTGAGTACTTCCGGAATTTTGTCGACTCC
TGTCTTCAGAAAATCCCTCAAGACAGACCAACCTCAGAGGTTCTCCTGAAGCACCGCTTT
GTGCTCCGGGAGCGGCCACCCACAGTCATCATGGACCTGATCCAGAGGACCAAGGATGCC
GTGCGGGAGCTGGACAACCTGCAGTACCGCAAGATGAAGAAGATCCTGTTCCAAGAGGCA
CCCAACGGCCCTGGTGCCGAGGCCCCAGAGGAGGAAGAGGAGGCCGAGCCCTACATGCAC
CGGGCCGGGACTCTGACCAGCCTCGAGAGTAGCCACTCAGTGCCCAGCATGTCCATCAGC
GCCTCCAGCCAGAGCAGCTCCGTCAACAGCCTAGCAGATGCCTCAGACAACGAGGAAGAG
GAGGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAAGGCCCTGAAGCCCGGGAGATGGCC
ATGATGCAGGAGGGGGAGCACACAGTCACCTCTCACAGCTCCATTATCCACCGGCTGCCG
GGCTCTGACAACCTATATGATGACCCCTACCAGCCAGAGATAACCCCCAGCCCTCTCCAG
CCGCCTGCAGCCCCAGCTCCCACTTCCACCACCTCTTCCGCCCGCCGCCGGGCCTACTGC
CGTAACCGAGACCACTTTGCCACCATCCGAACCGCCTCCCTGGTCAGCCGTCAGATCCAG
GAGCATGAGCAGGACTCTGCGCTGCGGGAGCAGCTGAGCGGCTATAAGCGGATGCGACGA
CAGCACCAGAAGCAGCTGCTGGCCCTGGAGTCACGGCTGAGGGGTGAACGGGAGGAGCAC
AGTGCACGGCTGCAGCGGGAGCTTGAGGCGCAGCGGGCTGGCTTTGGGGCAGAGGCAGAA
AAGCTGGCCCGGCGGCACCAGGCCATAGGTGAGAAGGAGGCACGAGCTGCCCAGGCCGAG
GAGCGGAAGTTCCAGCAGCACATCCTTGGGCAGCAGAAGAAGGAGCTGGCTGCCCTGCTG
GAGGCACAGAAGCGGACCTACAAACTTCGCAAGGAACAGCTGAAGGAGGAGCTCCAGGAG
AACCCCAGCACTCCCAAGCGGGAGAAGGCCGAGTGGCTGCTGCGGCAGAAGGAGCAGCTC
CAGCAGTGCCAGGCGGAGGAGGAAGCAGGGCTGCTGCGGCGGCAGCGCCAGTACTTTGAG
CTGCAGTGTCGCCAGTACAAGCGCAAGATGTTGCTGGCTCGGCACAGCCTGGACCAGGAC
CTGCTGCGGGAGGACCTGAACAAGAAGCAGACCCAGAAGGACTTGGAGTGTGCACTGCTG
CTTCGGCAGCACGAGGCCACGCGGGAGCTGGAGCTGCGGCAGCTCCAGGCCGTGCAGCGC
ACGCGGGCTGAGCTCACCCGCCTGCAGCACCAGACGGAGCTGGGCAACCAGCTGGAGTAC
AACAAGCGGCGTGAGCAAGAGTTGCGGCAGAAGCATGCGGCCCAGGTTCGCCAGCAGCCC
AAGAGCCTCAAAGAGAGGAGCATTGTTGGCCAGGAGGAGGCTGGGACATGGAGCTTGTGG
GGGAAGGAGGATGAGAGTCTTCTGGATGAGGAGTTTGAGCTTGGCTGGGTCCAGGGCCCA
GCACTGACTCCCGTCCCTGAGGAGGAGGAAGAAGAGGAAGAGGGGGCTCCGATTGGGACC
CCTAGGGATCCTGGAGATGGTTGTCCTTCCCCCGACATCCCTCCTGAACCCCCTCCAACA
CACCTGAGGCCCTGCCCTGCCAGCCAGCTCCCTGGACTCCTGTCCCATGGCCTCCTGGCC
GGCCTCTCCTTTGCAGTGGGGTCCTCCTCTGGCCTCCTGCCCCTCCTGCTGCTGCTGCTG
CTTCCATTGCTGGCAGCCCAGGGTGGGGGTGGCCTGCAGGCAGCGCTGCTGGCCCTTGAG
GTGGGGCTGGTGGGTCTGGGGGCCTCCTACCTGCTCCTTTGTACAGCCCTGCACCTGCCC
TCCAGTCTTTTCCTACTCCTGGCCCAGGGTACCGCACTGGGGGCCGTCCTGGGCCTGAGC
TGGCGCCGAGGCCTCATGGGTGTTCCCCTGGGCCTTGGAGCTGCCTGGCTCTTAGCTTGG
CCAGGCCTAGCTCTACCTCTGGTGGCTATGGCAGCGGGGGGCAGATGGGTGCGGCAGCAG
GGCCCCCGGGTGCGCCGGGGCATATCTCGACTCTGGTTGCGGGTTCTGCTGCGCCTGTCA
CCCATGGCCTTCCGGGCCCTGCAGGGCTGTGGGGCTGTGGGGGACCGGGGTCTGTTTGCA
CTGTACCCCAAAACCAACAAGGATGGCTTCCGCAGCCGCCTGCCCGTCCCTGGGCCCCGG
CGGCGTAATCCCCGCACCACCCAACACCCATTAGCTCTGTTGGCAAGGGTCTGGGTCCTG
TGCAAGGGCTGGAACTGGCGTCTGGCACGGGCCAGCCAGGGTTTAGCATCCCACTTGCCC
CCGTGGGCCATCCACACACTGGCCAGCTGGGGCCTGCTTCGGGGTGAACGGCCCACCCGA
ATCCCCCGGCTACTACCACGCAGCCAGCGCCAGCTAGGGCCCCCTGCCTCCCGCCAGCCA
CTGCCAGGGACTCTAGCCGGGCGGAGGTCACGCACCCGCCAGTCCCGGGCCCTGCCCCCC
TGGAGGTAG
Chromosome Location
16
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9UL54
UniProtKB Entry NameTAOK2_HUMAN
HGNC IDHGNC:16835
General References
  1. Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD: PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. J Biol Chem. 2000 Feb 11;275(6):4311-22. [Article]
  2. Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ: Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. Oncogene. 2003 Sep 18;22(40):6129-41. [Article]
  3. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Dec 31;5(6):355-64. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  5. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  6. Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA: The sequence and analysis of duplication-rich human chromosome 16. Nature. 2004 Dec 23;432(7020):988-94. [Article]
  7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  8. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [Article]
  9. Chen Z, Cobb MH: Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J Biol Chem. 2001 May 11;276(19):16070-5. Epub 2001 Mar 8. [Article]
  10. Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD: The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. J Biol Chem. 2003 May 16;278(20):18085-91. Epub 2003 Mar 13. [Article]
  11. Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH: TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J Biol Chem. 2003 Jun 20;278(25):22278-83. Epub 2003 Mar 28. [Article]
  12. Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J: Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem. 2006 Sep 29;281(39):28802-10. Epub 2006 Aug 7. [Article]
  13. Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH: TAO kinases mediate activation of p38 in response to DNA damage. EMBO J. 2007 Apr 18;26(8):2005-14. Epub 2007 Mar 29. [Article]
  14. Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD: Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing. J Biol Chem. 2007 Mar 2;282(9):6484-93. Epub 2006 Dec 11. [Article]
  15. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
  16. Anand R, Maksimoska J, Pagano N, Wong EY, Gimotty PA, Diamond SL, Meggers E, Marmorstein R: Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. J Med Chem. 2009 Mar 26;52(6):1602-11. doi: 10.1021/jm8005806. [Article]
  17. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [Article]
  18. McNeer JL, Goussetis DJ, Sassano A, Dolniak B, Kroczynska B, Glaser H, Altman JK, Platanias LC: Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1. Mol Pharmacol. 2010 May;77(5):828-35. doi: 10.1124/mol.109.061507. Epub 2010 Feb 16. [Article]
  19. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  20. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  21. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04522DexfosfoserineexperimentalunknownDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails