Serine/threonine-protein kinase TAO2
Details
- Name
- Serine/threonine-protein kinase TAO2
- Synonyms
- 2.7.11.1
- hKFC-C
- KIAA0881
- Kinase from chicken homolog C
- MAP3K17
- Prostate-derived STE20-like kinase 1
- Prostate-derived sterile 20-like kinase 1
- PSK
- PSK-1
- PSK1
- Thousand and one amino acid protein kinase 2
- Gene Name
- TAOK2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009551|Serine/threonine-protein kinase TAO2 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY NKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQ EAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVW GLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPE EEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVG SSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLL AQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRG ISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTT QHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPR SQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR
- Number of residues
- 1235
- Molecular Weight
- 138250.17
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / MAP kinase kinase kinase activity / mitogen-activated protein kinase kinase binding / protein serine/threonine kinase activityProcessesactin cytoskeleton organization / activation of MAPKK activity / apoptotic process / cell migration / cellular response to DNA damage stimulus / focal adhesion assembly / G2 DNA damage checkpoint / positive regulation of JNK cascade / positive regulation of stress-activated MAPK cascade / protein targeting to membrane / regulation of apoptotic process / regulation of cell growth / regulation of cell shape / regulation of mitotic cell cycle / response to stress / stress-activated MAPK cascadeComponentscytoplasm / cytoplasmic membrane-bounded vesicle / cytoplasmic vesicle membrane / cytoskeleton / dendrite / integral component of membrane / nucleolus / nucleus / receptor complex
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- 965-985 987-1007 1012-1032 1043-1063 1166-1186
- Cellular Location
- Cytoplasmic vesicle membrane
- Gene sequence
>lcl|BSEQ0021713|Serine/threonine-protein kinase TAO2 (TAOK2) ATGCCAGCTGGGGGCCGGGCCGGGAGCCTGAAGGACCCAGATGTGGCTGAGCTCTTCTTC AAGGATGACCCAGAAAAGCTCTTCTCTGACCTCCGGGAAATTGGCCATGGCAGCTTTGGA GCCGTATACTTTGCCCGGGATGTCCGGAATAGTGAGGTGGTGGCCATCAAGAAGATGTCC TACAGTGGGAAGCAGTCCAATGAGAAATGGCAAGACATCATCAAGGAGGTGCGGTTCTTA CAGAAGCTCCGGCATCCCAACACCATTCAGTACCGGGGCTGTTACCTGAGGGAGCACACG GCTTGGCTGGTAATGGAGTATTGCCTGGGCTCAGCTTCTGACCTTCTAGAAGTGCACAAG AAACCCCTTCAGGAGGTAGAGATCGCAGCTGTGACCCACGGGGCGCTTCAGGGCCTGGCA TATCTGCACTCCCACAACATGATCCATAGGGATGTGAAGGCTGGAAACATCCTGCTGTCA GAGCCAGGGTTAGTGAAGCTAGGGGACTTTGGTTCTGCGTCCATCATGGCACCTGCCAAC TCCTTCGTGGGCACCCCATACTGGATGGCACCCGAGGTGATCCTGGCCATGGATGAGGGG CAGTACGATGGCAAAGTGGACGTCTGGTCCTTGGGGATAACCTGCATCGAGCTGGCTGAA CGGAAACCACCGCTCTTTAACATGAATGCGATGAGTGCCTTATACCACATTGCACAGAAC GAATCCCCCGTGCTCCAGTCAGGACACTGGTCTGAGTACTTCCGGAATTTTGTCGACTCC TGTCTTCAGAAAATCCCTCAAGACAGACCAACCTCAGAGGTTCTCCTGAAGCACCGCTTT GTGCTCCGGGAGCGGCCACCCACAGTCATCATGGACCTGATCCAGAGGACCAAGGATGCC GTGCGGGAGCTGGACAACCTGCAGTACCGCAAGATGAAGAAGATCCTGTTCCAAGAGGCA CCCAACGGCCCTGGTGCCGAGGCCCCAGAGGAGGAAGAGGAGGCCGAGCCCTACATGCAC CGGGCCGGGACTCTGACCAGCCTCGAGAGTAGCCACTCAGTGCCCAGCATGTCCATCAGC GCCTCCAGCCAGAGCAGCTCCGTCAACAGCCTAGCAGATGCCTCAGACAACGAGGAAGAG GAGGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAAGGCCCTGAAGCCCGGGAGATGGCC ATGATGCAGGAGGGGGAGCACACAGTCACCTCTCACAGCTCCATTATCCACCGGCTGCCG GGCTCTGACAACCTATATGATGACCCCTACCAGCCAGAGATAACCCCCAGCCCTCTCCAG CCGCCTGCAGCCCCAGCTCCCACTTCCACCACCTCTTCCGCCCGCCGCCGGGCCTACTGC CGTAACCGAGACCACTTTGCCACCATCCGAACCGCCTCCCTGGTCAGCCGTCAGATCCAG GAGCATGAGCAGGACTCTGCGCTGCGGGAGCAGCTGAGCGGCTATAAGCGGATGCGACGA CAGCACCAGAAGCAGCTGCTGGCCCTGGAGTCACGGCTGAGGGGTGAACGGGAGGAGCAC AGTGCACGGCTGCAGCGGGAGCTTGAGGCGCAGCGGGCTGGCTTTGGGGCAGAGGCAGAA AAGCTGGCCCGGCGGCACCAGGCCATAGGTGAGAAGGAGGCACGAGCTGCCCAGGCCGAG GAGCGGAAGTTCCAGCAGCACATCCTTGGGCAGCAGAAGAAGGAGCTGGCTGCCCTGCTG GAGGCACAGAAGCGGACCTACAAACTTCGCAAGGAACAGCTGAAGGAGGAGCTCCAGGAG AACCCCAGCACTCCCAAGCGGGAGAAGGCCGAGTGGCTGCTGCGGCAGAAGGAGCAGCTC CAGCAGTGCCAGGCGGAGGAGGAAGCAGGGCTGCTGCGGCGGCAGCGCCAGTACTTTGAG CTGCAGTGTCGCCAGTACAAGCGCAAGATGTTGCTGGCTCGGCACAGCCTGGACCAGGAC CTGCTGCGGGAGGACCTGAACAAGAAGCAGACCCAGAAGGACTTGGAGTGTGCACTGCTG CTTCGGCAGCACGAGGCCACGCGGGAGCTGGAGCTGCGGCAGCTCCAGGCCGTGCAGCGC ACGCGGGCTGAGCTCACCCGCCTGCAGCACCAGACGGAGCTGGGCAACCAGCTGGAGTAC AACAAGCGGCGTGAGCAAGAGTTGCGGCAGAAGCATGCGGCCCAGGTTCGCCAGCAGCCC AAGAGCCTCAAAGAGAGGAGCATTGTTGGCCAGGAGGAGGCTGGGACATGGAGCTTGTGG GGGAAGGAGGATGAGAGTCTTCTGGATGAGGAGTTTGAGCTTGGCTGGGTCCAGGGCCCA GCACTGACTCCCGTCCCTGAGGAGGAGGAAGAAGAGGAAGAGGGGGCTCCGATTGGGACC CCTAGGGATCCTGGAGATGGTTGTCCTTCCCCCGACATCCCTCCTGAACCCCCTCCAACA CACCTGAGGCCCTGCCCTGCCAGCCAGCTCCCTGGACTCCTGTCCCATGGCCTCCTGGCC GGCCTCTCCTTTGCAGTGGGGTCCTCCTCTGGCCTCCTGCCCCTCCTGCTGCTGCTGCTG CTTCCATTGCTGGCAGCCCAGGGTGGGGGTGGCCTGCAGGCAGCGCTGCTGGCCCTTGAG GTGGGGCTGGTGGGTCTGGGGGCCTCCTACCTGCTCCTTTGTACAGCCCTGCACCTGCCC TCCAGTCTTTTCCTACTCCTGGCCCAGGGTACCGCACTGGGGGCCGTCCTGGGCCTGAGC TGGCGCCGAGGCCTCATGGGTGTTCCCCTGGGCCTTGGAGCTGCCTGGCTCTTAGCTTGG CCAGGCCTAGCTCTACCTCTGGTGGCTATGGCAGCGGGGGGCAGATGGGTGCGGCAGCAG GGCCCCCGGGTGCGCCGGGGCATATCTCGACTCTGGTTGCGGGTTCTGCTGCGCCTGTCA CCCATGGCCTTCCGGGCCCTGCAGGGCTGTGGGGCTGTGGGGGACCGGGGTCTGTTTGCA CTGTACCCCAAAACCAACAAGGATGGCTTCCGCAGCCGCCTGCCCGTCCCTGGGCCCCGG CGGCGTAATCCCCGCACCACCCAACACCCATTAGCTCTGTTGGCAAGGGTCTGGGTCCTG TGCAAGGGCTGGAACTGGCGTCTGGCACGGGCCAGCCAGGGTTTAGCATCCCACTTGCCC CCGTGGGCCATCCACACACTGGCCAGCTGGGGCCTGCTTCGGGGTGAACGGCCCACCCGA ATCCCCCGGCTACTACCACGCAGCCAGCGCCAGCTAGGGCCCCCTGCCTCCCGCCAGCCA CTGCCAGGGACTCTAGCCGGGCGGAGGTCACGCACCCGCCAGTCCCGGGCCCTGCCCCCC TGGAGGTAG
- Chromosome Location
- 16
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9UL54 UniProtKB Entry Name TAOK2_HUMAN HGNC ID HGNC:16835 - General References
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