Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.4.22.-
- p23
- Gene Name
- Not Available
- Organism
- HCV
- Amino acid sequence
>lcl|BSEQ0012649|Genome polyprotein MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRG RRQPIPKARQPEGRAWAQPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPTDPRRRSRNLG KVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLA LLSCLTIPASAYEVRNVSGVYHVTNDCSNASIVYEAADMIMHTPGCVPCVRENNSSRCWV ALTPTLAARNASVPTTTIRRHVDLLVGAAALCSAMYVGDLCGSVFLVAQLFTFSPRRHET VQDCNCSIYPGHVTGHRMAWDMMMNWSPTAALVVSQLLRIPQAVVDMVAGAHWGVLAGLA YYSMVGNWAKVLIVMLLFAGVDGGTYVTGGTMAKNTLGITSLFSPGSSQKIQLVNTNGSW HINRTALNCNDSLNTGFLAALFYVHKFNSSGCPERMASCSPIDAFAQGWGPITYNESHSS DQRPYCWHYAPRPCGIVPAAQVCGPVYCFTPSPVVVGTTDRFGVPTYSWGENETDVLLLN NTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGIGNKTLTCPTDCFRKHPEATYTKCGSG PWLTPRCLVHYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLEAACNWTRGERCNLEDRDRS ELSPLLLSTTEWQVLPCSFTTLPALSTGLIHLHQNVVDVQYLYGIGSAVVSFAIKWEYVL LLFLLLADARVCACLWMMLLIAQAEAALENLVVLNAASVAGAHGILSFLVFFCAAWYIKG RLVPGAAYALYGVWPLLLLLLALPPRAYAMDREMAASCGGAVFVGLILLTLSPHYKLFLA RLIWWLQYFITRAEAHLQVWIPPLNVRGGRDAVILLTCAIHPELIFTITKILLAILGPLM VLQAGITKVPYFVRAHGLIRACMLVRKVAGGHYVQMALMKLAALTGTYVYDHLTPLRDWA HAGLRDLAVAVEPVVFSDMETKVITWGADTAACGDIILGLPVSARRGREIHLGPADSLEG QGWRLLAPITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNGVCWT VYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCGSSDLYLVTRHADVI PVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVES METTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAA TLGFGAYMSKAHGIDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIIICDECHS TDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSSTGEIPFYGKAI PIETIKGGRHLIFCHSKKKCDELAAKLSGLGLNAVAYYRGLDVSVIPTSGDVIVVATDAL MTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRMGIYR FVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWES VFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHG PTPLLYRLGAVQNEVTTTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSV VIVGRIILSGKPAIIPDREVLYREFDEMEECASHLPYIEQGMQLAEQFKQKAIGLLQTAT KQAEAAAPVVESKWRTLEAFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSP LTTQHTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGKVLVDILAGYGAGVA GALVAFKVMSGEMPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLI AFASRGNHVSPTHYVPESDAAARVTQILSSLTITQLLKRLHQWINEDCSTPCSGSWLRDV WDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVK NGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFH YVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQL PCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHD SPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRK FPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTV SSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDL SDGSWSTVSEEASEDVVCCSMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATT SRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKF GYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIV FPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDT RCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRA SGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTE AMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETAR HTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQ IIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATC GKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSV GVGIYLLPNR
- Number of residues
- 3010
- Molecular Weight
- 326903.025
- Theoretical pI
- 8.13
- GO Classification
- Functionsactin binding / ATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / structural molecule activity / zinc ion bindingProcessesactin-dependent intracellular transport of virus / apoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / microtubule-dependent intracellular transport of viral material / modulation by virus of host G1/S transition checkpoint / pore formation by virus in membrane of host cell / positive regulation by symbiont of host protein levels / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transcription, RNA-templated / transformation of host cell by virus / viral RNA genome replication / virion attachment to host cellComponentsextracellular region / host cell cytoplasm / host cell endoplasmic reticulum / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell mitochondrial membrane / host cell mitochondrion / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
- General Function
- Zinc ion binding
- Specific Function
- Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity).P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity).Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity).NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves the host antiviral protein MAVS (By similarity). NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state.NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex (By similarity).NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity).NS5B is an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
- Pfam Domain Function
- Transmembrane Regions
- 169-189 359-379 726-746 758-778 783-803 814-834 882-902 929-949 1658-1678 1806-1826 1829-1849 1851-1871 1882-1902 2990-3010
- Cellular Location
- Host endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0007287|9033 bp ATGAGCACGAATCCTAAACCTCAAAGAAAAACCAAACGTAACACCAACCGCCGCCCACAG GACGTCAAGTTCCCGGGCGGTGGTCAGATCGTCGGTGGAGTTTACCTGTTGCCGCGCAGG GGCCCCAGGTTGGGTGTGCGCGCGACTAGGAAGACTTCCGAGCGGTCGCAACCTCGTGGA AGGCGACAACCTATCCCCAAGGCTCGCCAGCCCGAGGGTAGGGCCTGGGCTCAGCCCGGG TACCCCTGGCCCCTCTATGGCAATGAGGGCTTGGGGTGGGCAGGATGGCTCCTGTCACCC CGTGGCTCTCGGCCTAGTTGGGGCCCCACGGACCCCCGGCGTAGGTCGCGCAATTTGGGT AAGGTCATCGATACCCTCACGTGCGGCTTCGCCGATCTCATGGGGTACATTCCGCTCGTC GGCGCCCCCCTAGGGGGCGCTGCCAGGGCCCTGGCGCATGGCGTCCGGGTTCTGGAGGAC GGCGTGAACTATGCAACAGGGAATCTGCCCGGTTGCTCCTTTTCTATCTTCCTTTTGGCT TTGCTGTCCTGTTTGACCATCCCAGCTTCCGCTTATGAAGTGCGCAACGTATCCGGAGTG TACCATGTCACGAACGACTGCTCCAACGCAAGCATTGTGTATGAGGCAGCGGACATGATC ATGCATACCCCCGGGTGCGTGCCCTGCGTTCGGGAGAACAACTCCTCCCGCTGCTGGGTA GCGCTCACTCCCACGCTCGCGGCCAGGAACGCTAGCGTCCCCACTACGACGATACGACGC CATGTCGATTTGCTCGTTGGGGCGGCTGCTCTCTGCTCCGCTATGTACGTGGGAGATCTC TGCGGATCTGTTTTCCTCGTCGCCCAGCTGTTCACCTTCTCGCCTCGCCGGCACGAGACA GTACAGGACTGCAATTGCTCAATATATCCCGGCCACGTGACAGGTCACCGTATGGCTTGG GATATGATGATGAACTGGTCACCTACAGCAGCCCTAGTGGTATCGCAGTTACTCCGGATC CCACAAGCTGTCGTGGATATGGTGGCGGGGGCCCATTGGGGAGTCCTAGCGGGCCTTGCC TACTATTCCATGGTGGGGAACTGGGCTAAGGTTCTGATTGTGATGCTACTCTTTGCCGGC GTTGACGGGGGAACCTATGTGACAGGGGGGACGATGGCCAAAAACACCCTCGGGATTACG TCCCTCTTTTCACCCGGGTCATCCCAGAAAATCCAGCTTGTAAACACCAACGGCAGCTGG CACATCAACAGGACTGCCCTGAACTGCAATGACTCCCTCAACACTGGGTTCCTTGCTGCG CTGTTCTACGTGCACAAGTTCAACTCATCTGGATGCCCAGAGCGCATGGCCAGCTGCAGC CCCATCGACGCGTTCGCTCAGGGGTGGGGGCCCATCACTTACAATGAGTCACACAGCTCG GACCAGAGGCCTTATTGTTGGCACTACGCACCCCGGCCGTGCGGTATCGTACCCGCGGCG CAGGTGTGTGGTCCAGTGTACTGCTTCACCCCAAGCCCTGTCGTGGTGGGGACGACCGAC CGGTTCGGCGTCCCTACGTACAGTTGGGGGGAGAATGAGACGGACGTGCTGCTTCTTAAC AACACGCGGCCGCCGCAAGGCAACTGGTTTGGCTGTACATGGATGAATAGCACTGGGTTC ACCAAGACGTGCGGGGGCCCCCCGTGTAACATCGGGGGGATCGGCAATAAAACCTTGACC TGCCCCACGGACTGCTTCCGGAAGCACCCCGAGGCCACTTACACCAAGTGTGGTTCGGGG CCTTGGTTGACACCCAGATGCTTGGTCCACTACCCATACAGGCTTTGGCACTACCCCTGC ACTGTCAACTTTACCATCTTCAAGGTTAGGATGTACGTGGGGGGAGTGGAGCACAGGCTC GAAGCCGCATGCAATTGGACTCGAGGAGAGCGTTGTAACCTGGAGGACAGGGACAGATCA GAGCTTAGCCCGCTGCTGCTGTCTACAACGGAGTGGCAGGTATTGCCCTGTTCCTTCACC ACCCTACCGGCTCTGTCCACTGGTTTGATCCATCTCCATCAGAACGTCGTGGACGTACAA TACCTGTACGGTATAGGGTCGGCGGTTGTCTCCTTTGCAATCAAATGGGAGTATGTCCTG TTGCTCTTCCTTCTTCTGGCGGACGCGCGCGTCTGTGCCTGCTTGTGGATGATGCTGCTG ATAGCTCAAGCTGAGGCCGCCCTAGAGAACCTGGTGGTCCTCAACGCGGCATCCGTGGCC GGGGCGCATGGCATTCTCTCCTTCCTCGTGTTCTTCTGTGCTGCCTGGTACATCAAGGGC AGGCTGGTCCCTGGGGCGGCATATGCCCTCTACGGCGTATGGCCGCTACTCCTGCTCCTG CTGGCGTTACCACCACGAGCATACGCCATGGACCGGGAGATGGCAGCATCGTGCGGAGGC GCGGTTTTCGTAGGTCTGATACTCTTGACCTTGTCACCGCACTATAAGCTGTTCCTCGCT AGGCTCATATGGTGGTTACAATATTTTATCACCAGGGCCGAGGCACACTTGCAAGTGTGG ATCCCCCCCCTCAACGTTCGGGGGGGCCGCGATGCCGTCATCCTCCTCACGTGCGCGATC CACCCAGAGCTAATCTTTACCATCACCAAAATCTTGCTCGCCATACTCGGTCCACTCATG GTGCTCCAGGCTGGTATAACCAAAGTGCCGTACTTCGTGCGCGCACACGGGCTCATTCGT GCATGCATGCTGGTGCGGAAGGTTGCTGGGGGTCATTATGTCCAAATGGCTCTCATGAAG TTGGCCGCACTGACAGGTACGTACGTTTATGACCATCTCACCCCACTGCGGGACTGGGCC CACGCGGGCCTACGAGACCTTGCGGTGGCAGTTGAGCCCGTCGTCTTCTCTGATATGGAG ACCAAGGTTATCACCTGGGGGGCAGACACCGCGGCGTGTGGGGACATCATCTTGGGCCTG CCCGTCTCCGCCCGCAGGGGGAGGGAGATACATCTGGGACCGGCAGACAGCCTTGAAGGG CAGGGGTGGCGACTCCTCGCGCCTATTACGGCCTACTCCCAACAGACGCGAGGCCTACTT GGCTGCATCATCACTAGCCTCACAGGCCGGGACAGGAACCAGGTCGAGGGGGAGGTCCAA GTGGTCTCCACCGCAACACAATCTTTCCTGGCGACCTGCGTCAATGGCGTGTGTTGGACT GTCTATCATGGTGCCGGCTCAAAGACCCTTGCCGGCCCAAAGGGCCCAATCACCCAAATG TACACCAATGTGGACCAGGACCTCGTCGGCTGGCAAGCGCCCCCCGGGGCGCGTTCCTTG ACACCATGCACCTGCGGCAGCTCGGACCTTTACTTGGTCACGAGGCATGCCGATGTCATT CCGGTGCGCCGGCGGGGCGACAGCAGGGGGAGCCTACTCTCCCCCAGGCCCGTCTCCTAC TTGAAGGGCTCTTCGGGCGGTCCACTGCTCTGCCCCTCGGGGCACGCTGTGGGCATCTTT CGGGCTGCCGTGTGCACCCGAGGGGTTGCGAAGGCGGTGGACTTTGTACCCGTCGAGTCT ATGGAAACCACTATGCGGTCCCCGGTCTTCACGGACAACTCGTCCCCTCCGGCCGTACCG CAGACATTCCAGGTGGCCCATCTACACGCCCCTACTGGTAGCGGCAAGAGCACTAAGGTG CCGGCTGCGTATGCAGCCCAAGGGTATAAGGTGCTTGTCCTGAACCCGTCCGTCGCCGCC ACCCTAGGTTTCGGGGCGTATATGTCTAAGGCACATGGTATCGACCCTAACATCAGAACC GGGGTAAGGACCATCACCACGGGTGCCCCCATCACGTACTCCACCTATGGCAAGTTTCTT GCCGACGGTGGTTGCTCTGGGGGCGCCTATGACATCATAATATGTGATGAGTGCCACTCA ACTGACTCGACCACTATCCTGGGCATCGGCACAGTCCTGGACCAAGCGGAGACGGCTGGA GCGCGACTCGTCGTGCTCGCCACCGCTACGCCTCCGGGATCGGTCACCGTGCCACATCCA AACATCGAGGAGGTGGCTCTGTCCAGCACTGGAGAAATCCCCTTTTATGGCAAAGCCATC CCCATCGAGACCATCAAGGGGGGGAGGCACCTCATTTTCTGCCATTCCAAGAAGAAATGT GATGAGCTCGCCGCGAAGCTGTCCGGCCTCGGACTCAATGCTGTAGCATATTACCGGGGC CTTGATGTATCCGTCATACCAACTAGCGGAGACGTCATTGTCGTAGCAACGGACGCTCTA ATGACGGGCTTTACCGGCGATTTCGACTCAGTGATCGACTGCAATACATGTGTCACCCAG ACAGTCGACTTCAGCCTGGACCCGACCTTCACCATTGAGACGACGACCGTGCCACAAGAC GCGGTGTCACGCTCGCAGCGGCGAGGCAGGACTGGTAGGGGCAGGATGGGCATTTACAGG TTTGTGACTCCAGGAGAACGGCCCTCGGGCATGTTCGATTCCTCGGTTCTGTGCGAGTGC TATGACGCGGGCTGTGCTTGGTACGAGCTCACGCCCGCCGAGACCTCAGTTAGGTTGCGG GCTTACCTAAACACACCAGGGTTGCCCGTCTGCCAGGACCATCTGGAGTTCTGGGAGAGC GTCTTTACAGGCCTCACCCACATAGACGCCCATTTCTTGTCCCAGACTAAGCAGGCAGGA GACAACTTCCCCTACCTGGTAGCATACCAGGCTACGGTGTGCGCCAGGGCTCAGGCTCCA CCTCCATCGTGGGACCAAATGTGGAAGTGTCTCATACGGCTAAAGCCTACGCTGCACGGG CCAACGCCCCTGCTGTATAGGCTGGGAGCCGTTCAAAACGAGGTTACTACCACACACCCC ATAACCAAATACATCATGGCATGCATGTCGGCTGACCTGGAGGTCGTCACGAGCACCTGG GTGCTGGTAGGCGGAGTCCTAGCAGCTCTGGCCGCGTATTGCCTGACAACAGGCAGCGTG GTCATTGTGGGCAGGATCATCTTGTCCGGAAAGCCGGCCATCATTCCCGACAGGGAAGTC CTTTACCGGGAGTTCGATGAGATGGAAGAGTGCGCCTCACACCTCCCTTACATCGAACAG GGAATGCAGCTCGCCGAACAATTCAAACAGAAGGCAATCGGGTTGCTGCAAACAGCCACC AAGCAAGCGGAGGCTGCTGCTCCCGTGGTGGAATCCAAGTGGCGGACCCTCGAAGCCTTC TGGGCGAAGCATATGTGGAATTTCATCAGCGGGATACAATATTTAGCAGGCTTGTCCACT CTGCCTGGCAACCCCGCGATAGCATCACTGATGGCATTCACAGCCTCTATCACCAGCCCG CTCACCACCCAACATACCCTCCTGTTTAACATCCTGGGGGGATGGGTGGCCGCCCAACTT GCTCCTCCCAGCGCTGCTTCTGCTTTCGTAGGCGCCGGCATCGCTGGAGCGGCTGTTGGC AGCATAGGCCTTGGGAAGGTGCTTGTGGATATTTTGGCAGGTTATGGAGCAGGGGTGGCA GGCGCGCTCGTGGCCTTTAAGGTCATGAGCGGCGAGATGCCCTCCACCGAGGACCTGGTT AACCTACTCCCTGCTATCCTCTCCCCTGGCGCCCTAGTCGTCGGGGTCGTGTGCGCAGCG ATACTGCGTCGGCACGTGGGCCCAGGGGAGGGGGCTGTGCAGTGGATGAACCGGCTGATA GCGTTCGCTTCGCGGGGTAACCACGTCTCCCCCACGCACTATGTGCCTGAGAGCGACGCT GCAGCACGTGTCACTCAGATCCTCTCTAGTCTTACCATCACTCAGCTGCTGAAGAGGCTT CACCAGTGGATCAACGAGGACTGCTCCACGCCATGCTCCGGCTCGTGGCTAAGAGATGTT TGGGATTGGATATGCACGGTGTTGACTGATTTCAAGACCTGGCTCCAGTCCAAGCTCCTG CCGCGATTGCCGGGAGTCCCCTTCTTCTCATGTCAACGTGGGTACAAGGGAGTCTGGCGG GGCGACGGCATCATGCAAACCACCTGCCCATGTGGAGCACAGATCACCGGACATGTGAAA AACGGTTCCATGAGGATCGTGGGGCCTAGGACCTGTAGTAACACGTGGCATGGAACATTC CCCATTAACGCGTACACCACGGGCCCCTGCACGCCCTCCCCGGCGCCAAATTATTCTAGG GCGCTGTGGCGGGTGGCTGCTGAGGAGTACGTGGAGGTTACGCGGGTGGGGGATTTCCAC TACGTGACGGGCATGACCACTGACAACGTAAAGTGCCCGTGTCAGGTTCCGGCCCCCGAA TTCTTCACAGAAGTGGATGGGGTGCGGTTGCACAGGTACGCTCCAGCGTGCAAACCCCTC CTACGGGAGGAGGTCACATTCCTGGTCGGGCTCAATCAATACCTGGTTGGGTCACAGCTC CCATGCGAGCCCGAACCGGACGTAGCAGTGCTCACTTCCATGCTCACCGACCCCTCCCAC ATTACGGCGGAGACGGCTAAGCGTAGGCTGGCCAGGGGATCTCCCCCCTCCTTGGCCAGC TCATCAGCTAGCCAGCTGTCTGCGCCTTCCTTGAAGGCAACATGCACTACCCGTCATGAC TCCCCGGACGCTGACCTCATCGAGGCCAACCTCCTGTGGCGGCAGGAGATGGGCGGGAAC ATCACCCGCGTGGAGTCAGAAAATAAGGTAGTAATTTTGGACTCTTTCGAGCCGCTCCAA GCGGAGGAGGATGAGAGGGAAGTATCCGTTCCGGCGGAGATCCTGCGGAGGTCCAGGAAA TTCCCTCGAGCGATGCCCATATGGGCACGCCCGGATTACAACCCTCCACTGTTAGAGTCC TGGAAGGACCCGGACTACGTCCCTCCAGTGGTACACGGGTGTCCATTGCCGCCTGCCAAG GCCCCTCCGATACCACCTCCACGGAGGAAGAGGACGGTTGTCCTGTCAGAATCTACCGTG TCTTCTGCCTTGGCGGAGCTCGCCACAAAGACCTTCGGCAGCTCCGAATCGTCGGCCGTC GACAGCGGCACGGCAACGGCCTCTCCTGACCAGCCCTCCGACGACGGCGACGCGGGATCC GACGTTGAGTCGTACTCCTCCATGCCCCCCCTTGAGGGGGAGCCGGGGGATCCCGATCTC AGCGACGGGTCTTGGTCTACCGTAAGCGAGGAGGCTAGTGAGGACGTCGTCTGCTGCTCG ATGTCCTACACATGGACAGGCGCCCTGATCACGCCATGCGCTGCGGAGGAAACCAAGCTG CCCATCAATGCACTGAGCAACTCTTTGCTCCGTCACCACAACTTGGTCTATGCTACAACA TCTCGCAGCGCAAGCCTGCGGCAGAAGAAGGTCACCTTTGACAGACTGCAGGTCCTGGAC GACCACTACCGGGACGTGCTCAAGGAGATGAAGGCGAAGGCGTCCACAGTTAAGGCTAAA CTTCTATCCGTGGAGGAAGCCTGTAAGCTGACGCCCCCACATTCGGCCAGATCTAAATTT GGCTATGGGGCAAAGGACGTCCGGAACCTATCCAGCAAGGCCGTTAACCACATCCGCTCC GTGTGGAAGGACTTGCTGGAAGACACTGAGACACCAATTGACACCACCATCATGGCAAAA AATGAGGTTTTCTGCGTCCAACCAGAGAAGGGGGGCCGCAAGCCAGCTCGCCTTATCGTA TTCCCAGATTTGGGGGTTCGTGTGTGCGAGAAAATGGCCCTTTACGATGTGGTCTCCACC CTCCCTCAGGCCGTGATGGGCTCTTCATACGGATTCCAATACTCTCCTGGACAGCGGGTC GAGTTCCTGGTGAATGCCTGGAAAGCGAAGAAATGCCCTATGGGCTTCGCATATGACACC CGCTGTTTTGACTCAACGGTCACTGAGAATGACATCCGTGTTGAGGAGTCAATCTACCAA TGTTGTGACTTGGCCCCCGAAGCCAGACAGGCCATAAGGTCGCTCACAGAGCGGCTTTAC ATCGGGGGCCCCCTGACTAATTCTAAAGGGCAGAACTGCGGCTATCGCCGGTGCCGCGCG AGCGGTGTACTGACGACCAGCTGCGGTAATACCCTCACATGTTACTTGAAGGCCGCTGCG GCCTGTCGAGCTGCGAAGCTCCAGGACTGCACGATGCTCGTATGCGGAGACGACCTTGTC GTTATCTGTGAAAGCGCGGGGACCCAAGAGGACGAGGCGAGCCTACGGGCCTTCACGGAG GCTATGACTAGATACTCTGCCCCCCCTGGGGACCCGCCCAAACCAGAATACGACTTGGAG TTGATAACATCATGCTCCTCCAATGTGTCAGTCGCGCACGATGCATCTGGCAAAAGGGTG TACTATCTCACCCGTGACCCCACCACCCCCCTTGCGCGGGCTGCGTGGGAGACAGCTAGA CACACTCCAGTCAATTCCTGGCTAGGCAACATCATCATGTATGCGCCCACCTTGTGGGCA AGGATGATCCTGATGACTCATTTCTTCTCCATCCTTCTAGCTCAGGAACAACTTGAAAAA GCCCTAGATTGTCAGATCTACGGGGCCTGTTACTCCATTGAGCCACTTGACCTACCTCAG ATCATTCAACGACTCCATGGCCTTAGCGCATTTTCACTCCATAGTTACTCTCCAGGTGAG ATCAATAGGGTGGCTTCATGCCTCAGGAAACTTGGGGTACCGCCCTTGCGAGTCTGGAGA CATCGGGCCAGAAGTGTCCGCGCTAGGCTACTGTCCCAGGGGGGGAGGGCTGCCACTTGT GGCAAGTACCTCTTCAACTGGGCAGTAAGGACCAAGCTCAAACTCACTCCAATCCCGGCT GCGTCCCAGTTGGATTTATCCAGCTGGTTCGTTGCTGGTTACAGCGGGGGAGACATATAT CACAGCCTGTCTCGTGCCCGACCCCGCTGGTTCATGTGGTGCCTACTCCTACTTTCTGTA GGGGTAGGCATCTATCTACTCCCCAACCGATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9WMX2 UniProtKB Entry Name POLG_HCVCO GenBank Protein ID 5420377 GenBank Gene ID AJ238799 - General References
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- Foy E, Li K, Wang C, Sumpter R Jr, Ikeda M, Lemon SM, Gale M Jr: Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science. 2003 May 16;300(5622):1145-8. Epub 2003 Apr 17. [Article]
- Neddermann P, Quintavalle M, Di Pietro C, Clementi A, Cerretani M, Altamura S, Bartholomew L, De Francesco R: Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture. J Virol. 2004 Dec;78(23):13306-14. [Article]
- Appel N, Pietschmann T, Bartenschlager R: Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain. J Virol. 2005 Mar;79(5):3187-94. [Article]
- Otsuka M, Kato N, Moriyama M, Taniguchi H, Wang Y, Dharel N, Kawabe T, Omata M: Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses. Hepatology. 2005 May;41(5):1004-12. [Article]
- Quintavalle M, Sambucini S, Di Pietro C, De Francesco R, Neddermann P: The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation. J Virol. 2006 Nov;80(22):11305-12. Epub 2006 Aug 30. [Article]
- McLauchlan J: Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J Viral Hepat. 2000 Jan;7(1):2-14. [Article]
- Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM: Structural biology of hepatitis C virus. Hepatology. 2004 Jan;39(1):5-19. [Article]
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