Phospho-2-dehydro-3-deoxyheptonate aldolase

Details

Name
Phospho-2-dehydro-3-deoxyheptonate aldolase
Synonyms
  • 2.5.1.54
  • 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
  • DAHP synthase
  • Phospho-2-keto-3-deoxyheptonate aldolase
Gene Name
aroF
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0011226|Phospho-2-dehydro-3-deoxyheptonate aldolase
MIVVLKPGSTEEDIRKVVKLAESYNLKCHISKGQERTVIGIIGDDRYVVADKFESLDCVE
SVVRVLKPYKLVSREFHPEDTVIDLGDVKIGNGYFTIIAGPCSVEGREMLMETAHFLSEL
GVKVLRGGAYKPRTSPYSFQGLGEKGLEYLREAADKYGMYVVTEALGEDDLPKVAEYADI
IQIGARNAQNFRLLSKAGSYNKPVLLKRGFMNTIEEFLLSAEYIANSGNTKIILCERGIR
TFEKATRNTLDISAVPIIRKESHLPILVDPSHSGGRRDLVIPLSRAAIAVGAHGIIVEVH
PEPEKALSDGKQSLDFELFKELVQEMKKLADALGVKVN
Number of residues
338
Molecular Weight
37377.805
Theoretical pI
6.64
GO Classification
Functions
3-deoxy-7-phosphoheptulonate synthase activity / aldehyde-lyase activity
Processes
aromatic amino acid family biosynthetic process / chorismate biosynthetic process
General Function
Aldehyde-lyase activity
Specific Function
Catalyzes the condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011227|Phospho-2-dehydro-3-deoxyheptonate aldolase (aroF)
ATGATAGTCGTTTTGAAACCCGGTTCCACAGAAGAAGATATAAGGAAGGTGGTGAAGTTG
GCCGAGAGTTACAACTTGAAGTGTCACATTTCCAAAGGTCAGGAAAGAACGGTTATTGGG
ATCATCGGGGACGACAGGTACGTGGTGGCGGACAAGTTCGAGTCGCTGGATTGCGTGGAA
AGCGTTGTGAGGGTGCTCAAACCTTACAAACTCGTTTCTCGTGAGTTCCATCCGGAGGAC
ACGGTGATCGACCTCGGAGATGTGAAGATAGGAAACGGCTACTTCACCATCATAGCGGGA
CCGTGCTCAGTTGAAGGCAGGGAAATGCTCATGGAAACCGCACACTTTTTAAGCGAACTC
GGTGTTAAAGTTTTGAGGGGAGGGGCCTACAAGCCTCGAACATCTCCTTACTCTTTCCAA
GGACTCGGAGAAAAGGGGCTGGAATACCTGAGAGAGGCTGCCGACAAGTACGGTATGTAC
GTGGTGACGGAGGCTCTCGGAGAAGACGATCTTCCAAAAGTGGCCGAGTACGCTGATATC
ATTCAGATAGGAGCGAGAAACGCTCAGAACTTCAGATTGCTCTCTAAAGCGGGAAGCTAC
AACAAACCCGTTCTTCTGAAAAGGGGTTTCATGAACACCATCGAAGAGTTCCTTCTCTCC
GCTGAATACATTGCAAACTCTGGAAACACGAAGATCATACTGTGTGAAAGGGGAATCAGA
ACGTTCGAAAAGGCCACGAGGAACACACTCGATATATCCGCTGTTCCTATAATCAGAAAG
GAATCCCATCTTCCCATTCTGGTGGATCCGAGCCACTCTGGGGGAAGAAGAGACCTCGTT
ATTCCACTCTCCCGGGCCGCTATAGCGGTTGGAGCTCATGGAATCATTGTGGAGGTTCAT
CCGGAGCCGGAGAAGGCACTTTCGGATGGAAAACAGAGTCTTGACTTCGAGCTCTTCAAG
GAACTGGTTCAGGAAATGAAGAAACTCGCTGATGCCCTGGGGGTGAAGGTGAATTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9WYH8
UniProtKB Entry NameAROF_THEMA
GenBank Protein ID4980844
GenBank Gene IDAE000512
General References
  1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
  2. Wu J, Howe DL, Woodard RW: Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase? J Biol Chem. 2003 Jul 25;278(30):27525-31. Epub 2003 May 12. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01819PhosphoenolpyruvateexperimentalunknownDetails
DB03937D-erythrose 4-phosphateexperimentalunknownDetails