Phosphopantetheine adenylyltransferase

Details

Name

Phosphopantetheine adenylyltransferase

Synonyms

• 2.7.7.3
• Dephospho-CoA pyrophosphorylase
• kdtB
• Pantetheine-phosphate adenylyltransferase
• PPAT

Gene Name

coaD

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Amino acid sequence

>lcl|BSEQ0019211|Phosphopantetheine adenylyltransferase
MKAVYPGSFDPITLGHVDIIKRALSIFDELVVLVTENPRKKCMFTLEERKKLIEEVLSDL
DGVKVDVHHGLLVDYLKKHGIKVLVRGLRAVTDYEYELQMALANKKLYSDLETVFLIASE
KFSFISSSLVKEVALYGGDVTEWVPPEVARALNEKLKEGKR

Number of residues

161

Molecular Weight

18249.19

Theoretical pI

6.96

GO Classification

Functions

ATP binding / pantetheine-phosphate adenylyltransferase activity

Processes

coenzyme A biosynthetic process

Components

cytoplasm

General Function

Pantetheine-phosphate adenylyltransferase activity

Specific Function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Pfam Domain Function

• CTP_transf_like (PF01467)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0019212|Phosphopantetheine adenylyltransferase (coaD)
GTGAAAGCGGTCTATCCAGGATCTTTTGATCCCATCACTCTCGGACATGTGGACATCATC
AAAAGAGCGCTTTCTATTTTCGACGAGCTTGTGGTCCTCGTCACGGAGAATCCGAGAAAA
AAGTGTATGTTCACCTTGGAGGAAAGGAAAAAGCTGATAGAAGAGGTTCTCAGCGACCTA
GATGGAGTGAAGGTGGATGTTCATCATGGCTTACTCGTGGATTATTTGAAAAAACATGGT
ATAAAAGTCTTGGTGAGAGGACTCAGGGCTGTGACCGACTACGAGTACGAGCTGCAGATG
GCGCTTGCAAACAAAAAATTGTACAGCGATCTGGAAACAGTGTTTCTGATCGCAAGCGAA
AAATTTTCTTTCATATCCTCCAGTCTTGTGAAGGAAGTGGCCCTGTACGGCGGTGATGTG
ACCGAATGGGTACCACCCGAGGTAGCCAGAGCCCTGAACGAAAAGTTGAAGGAGGGAAAG
CGATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9WZK0
UniProtKB Entry Name	COAD_THEMA
GenBank Protein ID	4981265
GenBank Gene ID	AE000512

General References

1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03912	D-pantetheine 4'-phosphate	experimental	unknown		Details