Ribosomal RNA small subunit methyltransferase H

Details

Name

Ribosomal RNA small subunit methyltransferase H

Synonyms

• 16S rRNA m(4)C1402 methyltransferase
• 2.1.1.199
• mraW
• rRNA (cytosine-N(4)-)-methyltransferase RsmH

Gene Name

rsmH

Organism

Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Amino acid sequence

>lcl|BSEQ0016811|Ribosomal RNA small subunit methyltransferase H
MRKYSQRHIPVMVREVIEFLKPEDEKIILDCTVGEGGHSRAILEHCPGCRIIGIDVDSEV
LRIAEEKLKEFSDRVSLFKVSYREADFLLKTLGIEKVDGILMDLGVSTYQLKGENRGFTF
EREEPLDMRMDLESEVTAQKVLNELPEEELARIIFEYGEEKRFARRIARKIVENRPLNTT
LDLVKAVREALPSYEIRRRKRHFATKTFQAIRIYVNRELENLKEFLKKAEDLLNPGGRIV
VISFHSLEDRIVKETFRNSKKLRILTEKPVRPSEEEIRENPRARSGRLRAAERIEEGGD

Number of residues

299

Molecular Weight

34892.82

Theoretical pI

8.07

GO Classification

Functions

rRNA (cytosine-N4-)-methyltransferase activity

Processes

rRNA base methylation

Components

cytoplasm

General Function

Rrna (cytosine-n4-)-methyltransferase activity

Specific Function

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

Pfam Domain Function

• Methyltransf_5 (PF01795)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0016812|Ribosomal RNA small subunit methyltransferase H (rsmH)
ATGCGGAAATATTCGCAGCGACATATTCCTGTAATGGTTAGAGAAGTTATTGAGTTTCTG
AAACCGGAGGATGAGAAAATCATCCTCGATTGCACGGTAGGTGAAGGAGGACACTCTAGA
GCGATTTTGGAACACTGTCCGGGATGCAGAATCATAGGAATAGACGTTGATTCAGAAGTT
TTGCGGATCGCAGAAGAGAAATTGAAAGAATTCTCAGATCGTGTGAGTTTGTTCAAAGTC
TCCTACAGAGAAGCGGATTTTCTTCTTAAAACTTTAGGAATAGAAAAAGTAGATGGGATA
TTAATGGATCTTGGGGTTTCTACTTATCAACTCAAAGGAGAGAATCGGGGATTCACGTTC
GAGAGAGAAGAACCACTGGATATGCGTATGGATCTGGAAAGCGAAGTAACGGCTCAAAAG
GTATTGAATGAGTTACCGGAAGAGGAGTTAGCGAGGATAATCTTTGAGTACGGTGAAGAA
AAGAGATTCGCAAGGAGAATCGCCCGAAAGATCGTTGAAAATCGTCCCCTCAACACCACC
CTTGACCTTGTTAAAGCTGTGAGAGAAGCGCTTCCATCTTACGAGATCAGACGCCGCAAG
AGACACTTTGCAACGAAGACGTTCCAGGCTATAAGAATCTATGTCAACAGAGAACTTGAA
AATCTGAAAGAATTTCTGAAAAAAGCGGAGGATCTTCTAAACCCTGGTGGCAGAATAGTG
GTCATTTCCTTTCATTCTCTGGAGGATAGGATCGTCAAAGAGACGTTCAGAAATTCTAAA
AAGTTACGAATATTGACGGAAAAACCTGTTCGTCCTTCAGAAGAGGAAATAAGAGAAAAT
CCAAGAGCCAGGAGCGGACGTTTGCGCGCAGCGGAGCGGATAGAGGAAGGAGGAGATTGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9WZX6
UniProtKB Entry Name	RSMH_THEMA
GenBank Gene ID	AE000512

General References

1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
2. Miller DJ, Ouellette N, Evdokimova E, Savchenko A, Edwards A, Anderson WF: Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain. Protein Sci. 2003 Jul;12(7):1432-42. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01752	S-adenosyl-L-homocysteine	experimental	unknown		Details